Sonidegib for the treatment of advanced basal cell carcinoma: a comprehensive review of sonidegib and the BOLT trial with 12-month update.
Future Oncology 12(18):2095 (2016)
The Hedgehog inhibitors are promising alternative for patients with advanced basal cell carcinoma that are not amenable to radiotherapy or surgery. Sonidegib, also known as LDE225, is an orally available SMO antagonist that was recently approved by the US FDA for the treatment of patients with l...
In vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides.
Journal of Hepatology 64(4):781 (2016)
Current treatment of chronic hepatitis B virus infection (CHB) includes interferon and nucleos(t)ide analogues, which generally do not reduce HBV surface antigen (HBsAg) production, a constellation that is associated with poor prognosis of CHB. Here we evaluated the efficacy of an antisense appr...
Don't Go Chasing Waterfalls: Excessive Fluid Resuscitation in Severe Sepsis and Septic Shock.
Critical Care Nursing Quarterly 39(1):34 (2016)
Aggressive fluid resuscitation is the mainstay therapy in modern sepsis management. Its efficacy was demonstrated in the landmark study by Emmanuel Rivers in 2001. However, more recent evidence largely shows that a positive fluid balance increases mortality in critically ill patients with sepsis...
Glycocalyx in Sepsis Resuscitation.
Critical Care Nursing Quarterly 39(1):38 (2016)
Starling's forces are fundamental to our understanding of physiology. Based on his findings, hydrostatic pressure and oncotic pressure are crucial factors in the movement of intravascular and extravascular fluid. However, new literatures on endothelial glycocalyx, a layer of protective glycoprot...
A study in scarlet: restrictive red blood cell transfusion strategy.
Critical Care Nursing Quarterly 38(2):217 (2015)
Anemia due to various etiologies occurs in critically ill patients requiring blood transfusion. Traditional transfusion goals guide our transfusion to achieve a hemoglobin goal of at least 10 g/dL. However, it is becoming increasingly evident that a restrictive transfusion goal of 7 g/dL may imp...
Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.
Nature Communications 6:7339 (2015)
Diseases of lipid metabolism are a major cause of human morbidity, but no animal model entirely recapitulates human lipoprotein metabolism. Here we develop a xenograft mouse model using hepatocytes from a patient with familial hypercholesterolaemia caused by loss-of-function mutations in the low...
Follow me down the K-hole: ketamine and its modern applications.
Critical Care Nursing Quarterly 38(2):211 (2015)
Ketamine is a versatile anesthetic agent that has been in use since the Vietnam War. Its popularity grew in war time due to its unique pharmacological properties, yet its use dwindled because of some of its adverse effects. However, in specialty areas, ketamine remains the drug of choice and its...
Stuck Inside a Cloud: Optimizing Sedation to Reduce ICU-Associated Delirium in Geriatric Patients.
Critical Care Nursing Quarterly 38(3):245 (2015)
Elderly population account for more than 50% of all intensive care admissions, and during their stay, up to 87% of them suffer from delirium. There is a large body of evidence demonstrating increased mortality and worse cognitive function for elderly patients who become delirious during their in...
Delayed recurrence of sinonasal rhinosporidiosis.
American Journal of Otolaryngology 36(6):778 (2015)
The myth of 0.9% saline: neither normal nor physiological.
Critical Care Nursing Quarterly 38(4):385 (2015)
Normal saline is the crystalloid of choice for fluid resuscitation with its utility born out of the cholera epidemic of 1832. However, its ubiquitous usage is being challenged because of a growing body of evidence suggesting that a large volume infusion of normal saline does in fact have deleter...
Hepatic portal venous gas from nonischemic cause: a case report.
Critical Care Nursing Quarterly 38(4):390 (2015)
Propofol infusion syndrome: a rare but lethal complication.
Nursing 44(12):11 (2014)
Dexamethasone's effect in the retrocochlear auditory centers of a noise-induced hearing loss mouse model.
Otolaryngology -- Head and Neck Surgery 151(4):667 (2014)
Examine prophylactic effects of dexamethasone (Dex) in retrocochlear auditory centers in a noise-induced hearing loss (NIHL) mouse model.
Prospective animal study.
Academic research center.
Thirty-two mice were divided into control, untreated, saline (2 and 10 µL), and Dex (2 and 10 µL) groups. ...
Technical note: component separation technique with double-layered biologic mesh placement for neonate with large gastroschisis.
Journal of Plastic, Reconstructive & Aesthetic ... 67(9):e230 (2014)
Outcomes of children after esophagogastroduodenoscopy for chronic abdominal pain.
Clinical Gastroenterology and Hepatology 12(6):963 (2014)
Chronic abdominal pain is the most common indication for esophagogastroduodenoscopy (EGD) in children. However, little is known about the accuracy of EGD-based diagnosis or the outcomes of the patients who undergo this procedure. We examined the diagnostic yield of EGD and short-term outcomes of...
Academic rhinology: a survey of residency programs and rhinology faculty in the United States.
Allergy & Rhinology 4(4):321 (2014)
Rhinology has rapidly evolved as a subspecialty over the past decade. The professional activities of rhinology faculty in otolaryngology residency programs is an important defining feature of this process but remains incompletely understood.
An examination of faculty profiles of otolaryngology r...
Vertebrate animal models of glioma: Understanding the mechanisms and developing new therapies
Biochimica et Biophysica Acta (BBA) - Reviews o... 1836(1):158 (2013)
Glioblastoma Multiforme (GBM) is recognized as one of the most deadly cancers characterized by cellular atypia, severe necrosis, and high rate of angiogenesis. In this review, we discuss a diversified group of GBM xenograft models and compare them with the genetically engineered mouse ...
ZIP4 is a novel molecular marker for glioma.
Neuro-Oncology 15(8):1008 (2013)
Dysregulated zinc transport has been observed in many cancers. However, the status of zinc homeostasis and the expression profile of zinc transporters in brain and brain tumors have not been reported.
The gene profiles of 14 zinc importers (ZIPs) and 10 zinc exporters (ZnTs) in patients with gli...
Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair.
International Journal of Oncology 42(6):2046 (2013)
High resistance to traditional chemo- and radiotherapies contributes to the poor prognosis of pancreatic cancer (PC). Methyl-CpG binding domain protein 1 (MBD1), which plays an important role in disease progression, contributes to the drug resistance of PC cells; however, the mechanism underlyin...
Sa1541 EGD Directed Therapy in Children With Chronic Abdominal Pain
Gastrointestinal Endoscopy 77(5):AB244 (2013)