3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI.
Human Brain Mapping 31(5):786 (2010)
We applied the hippocampal radial atrophy mapping technique to the baseline and follow-up magnetic resonance image data of 169 amnestic mild cognitive impairment (MCI) participants in the imaging arm of the Alzheimer's Disease Cooperative Study MCI Donepezil/Vitamin E trial. Sixty percent of the...
Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders.
Current Alzheimer Research 6(2):144 (2009)
Immunization of patients with Alzheimer's disease (AD) with synthetic amyloid-beta peptide (Abeta(42)) (AN1792) was previously studied in a randomized, double-blind, placebo-controlled phase 2a clinical trial, Study AN1792(QS-21)-201. Treatment was discontinued following reports of encephalitis....
Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies.
Neuropsychology 22(6):729 (2008)
Dementia with Lewy bodies (DLB) is often characterized by pronounced impairment in visuospatial skills, attention, and executive functions. However, the strength of the phenotypic expression of DLB varies and may be weaker in patients with extensive concomitant Alzheimer's disease (AD). To deter...
High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial.
JAMA 300(15):1774 (2008)
Blood levels of homocysteine may be increased in Alzheimer disease (AD) and hyperhomocysteinemia may contribute to disease pathophysiology by vascular and direct neurotoxic mechanisms. Even in the absence of vitamin deficiency, homocysteine levels can be reduced by administration of high-dose su...
Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia.
Journal of Neurology 255(9):1302 (2008)
White matter hyperintensities (WMH) have an effect on cognition and are increased in severity among individuals with amnestic mild cognitive impairment (aMCI). The influence of WMH on progression of aMCI to Alzheimer's disease (AD) is less clear.
Data were drawn from a three-year prospective, do...
Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI.
Neurobiology of Aging 29(9):1285 (2008)
The vitamin E and donepezil trial for the treatment of amnestic mild cognitive impairment (MCI) was conducted at 69 centers in North America; 24 centers participated in an MRI sub study. The objective of this study was to evaluate the effect of treatment on MRI atrophy rates; and validate rate m...
Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease.
Archives of Neurology 65(8):1031 (2008)
To evaluate the safety, tolerability, and amyloid beta (Abeta) response to the gamma-secretase inhibitor LY450139 in Alzheimer disease.
Multicenter, randomized, double-blind, dose-escalation, placebo-controlled trial.
Community-based clinical research centers. Patients Fifty-one individuals with...
APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study.
International Journal of Geriatric Psychiatry 23(6):632 (2008)
The association between the APOE epsilon4 allele and depression was investigated in a retrospective study of 323 AD patients.
Patients were divided into demographically comparable groups based on the presence or absence of depression.
Results showed that the frequency of APOE epsilon4 allele was...
Cognitive discrepancies versus APOE genotype as predictors of cognitive decline in normal-functioning elderly individuals: a longitudinal study.
American Journal of Geriatric Psychiatry 16(5):366 (2008)
Cognitive-discrepancy analysis has been shown to be a useful technique for detecting subtle cognitive deficits in normal-functioning elderly individuals who are genetically at-risk for Alzheimer disease (AD). However, studies that have used cognitive-discrepancy measures to date have used retros...
Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease.
Human Molecular Genetics 17(5):759 (2008)
Late-onset Alzheimer's disease (LOAD) and Parkinson's disease (PD) are the most common neurodegenerative disorders and in both diseases susceptibility is known to be influenced by genes. We set out to identify novel susceptibility genes for LOAD by performing a large scale, multi-tiered associat...
Rofecoxib in patients with mild cognitive impairment: further analyses of data from a randomized, double-blind, trial.
Current Alzheimer Research 5(1):73 (2008)
A recent clinical trial in patients with Mild Cognitive Impairment (MCI) found an increased rate of possible or probable Alzheimer's disease (AD) diagnoses in patients assigned to rofecoxib compared to placebo. This unexpected finding was difficult to interpret due to methodological issues and a...
Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease.
Neuropsychology 21(6):696 (2007)
Previous research suggests that patients with Alzheimer's disease exhibit cognitive impairment in the years preceding a clinical diagnosis. Memory impairments are particularly pronounced, but the relative degree to which other cognitive functions are impaired and the speed with which they declin...
Density of the brain, decline of the mind: an atypical case of Fahr disease.
Archives of Neurology 64(5):756 (2007)
Nerve growth factor promotes survival of new neurons in the adult hippocampus.
Neurobiology of Disease 26(1):47 (2007)
Exogenously provided NGF enhances cognitive performance in impaired rodents and humans and is currently a promising compound for the treatment of dementia. To investigate whether NGF-dependent cognitive improvement may be due in part to increased hippocampal neurogenesis, adult and aged male rat...
Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response.
Neurobiology of Aging 28(2):238 (2007)
Previous studies of episodic memory report a greater extent of blood-oxygenation-level-dependent (BOLD) response in non-demented older adults with the apolipoprotein E epsilon-4 (APOE epsilon4) allele than in those without the allele. We conducted a functional MRI study to investigate whether AP...
Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia.
Archives of Neurology 64(1):108 (2007)
Individuals diagnosed as having mild cognitive impairment (MCI) have a high likelihood of progressing to dementia within 3 to 5 years, but not all individuals with MCI progress to dementia. Prognostic uncertainty suggests the need for additional measures to assist the clinician.
To assess the ad...
Disparate letter and semantic category fluency deficits in autopsy-confirmed frontotemporal dementia and Alzheimer's disease.
Neuropsychology 21(1):20 (2007)
Patients with autopsy-confirmed frontotemporal dementia (FTD; n = 16) and Alzheimer's disease (AD; n = 32) were compared on first-letter and semantic category fluency tasks. Despite being matched on age, education, and dementia severity, FTD patients performed worse overall and showed similar im...
Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms.
Molecular Neurodegeneration 2:7 (2007)
Animal studies suggest that brain apolipoprotein E (apoE) levels influence amyloid-beta (Abeta) deposition and thus risk for Alzheimer's disease (AD). We have previously demonstrated that deletion of the ATP-binding cassette A1 transporter (ABCA1) in mice causes dramatic reductions in brain and ...
Common threads in neurodegenerative disorders of aging.
Alzheimer's & Dementia 2(4):322 (2006)
DAPK1 variants are associated with Alzheimer's disease and allele-specific expression.
Human Molecular Genetics 15(17):2560 (2006)
Genetic factors play an important role in the etiology of late-onset Alzheimer's disease (LOAD). We tested gene-centric single nucleotide polymorphisms (SNPs) on chromosome 9 and identified two SNPs in the death-associated protein kinase, DAPK1, that show significant association with LOAD. SNP r...