1. Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica.

    British Journal of Clinical Pharmacology 82(1):108 (2016) PMID 27016000 PMCID PMC4917813

    BG00010 is a protein in the glial cell line-derived neurotrophic factor (GDNF) family. It is a selective ligand for the GDNF family receptor alpha-3 (GFRα3) co-receptor that normalizes cellular changes resulting from damage or disease, and potentially alleviates neuropathic pain. The main object...
  2. Contextual Predictors of Injection Drug Use Among Black Adolescents and Adults in US Metropolitan Areas, 1993-2007.

    American Journal of Public Health 106(3):517 (2016) PMID 26691126 PMCID PMC4815709

    We sought to determine whether contextual factors shape injection drug use among Black adolescents and adults. For this longitudinal study of 95 US metropolitan statistical areas (MSAs), we drew annual MSA-specific estimates of the prevalence of injection drug use (IDU) among Black adolescents a...
  3. Conserved patterns of axogenesis in the panarthropod brain.

    Arthropod Structure & Development 44(2):101 (2015) PMID 25483803

    Neuropils in the cerebral midline of Panarthropoda exhibit a wide spectrum of neuroarchitectures--from rudimentary to highly elaborated--and which at first sight defy a unifying neuroarchitectural principle. Developmental approaches have shown that in model arthropods such as insects, conserved ...
  4. More Than a Number: Unexpected Benefits of Return on Investment Analysis

    The Journal of Academic Librarianship 39(6):566 (2013)

    In 2010–2011, University of Colorado (CU) librarians implemented a multi-campus pilot study to measure the institutional value of library resources used by faculty in their research. The study incorporated quantitative methods including return on investment (ROI), cost benefit analysis...
  5. Urinalysis: new technologies, new potential.

    Medical Laboratory Observer 45(9):34 (2013) PMID 24147334

  6. A single ascending-dose study of BIIB037 in people with mild-to-moderate Alzheimer's disease

    Alzheimer's & Dementia 9(4):P290 (2013)

  7. Postembryonic development of astrocyte-like glia of the central complex in the grasshopper Schistocerca gregaria.

    Cell and Tissue Research 351(3):361 (2013) PMID 23250573

    Central complex modules in the postembryonic brain of the grasshopper Schistocerca gregaria are enveloped by Repo-positive/glutamine-synthetase-positive astrocyte-like glia. Such cells constitute Rind-Neuropil Interface glia. We have investigated the postembryonic development of these glia and t...
  8. Astrocyte-like glia associated with the embryonic development of the central complex in the grasshopper Schistocerca gregaria.

    Development Genes and Evolution 221(3):141 (2011) PMID 21556852

    In this study we employed the expression of the astrocyte-specific enzyme glutamine synthetase, in addition to the glia-specific marker Repo, to characterize glia cell types associated with the embryonic development of the central complex in the grasshopper Schistocerca gregaria. Double labeling...
  9. Embryonic development of the insect central complex: Insights from lineages in the grasshopper andDrosophila

    Arthropod Structure & Development 40(4):334 (2011) PMID 21382507

    The neurons of the insect brain derive from neuroblasts which delaminate from the neuroectoderm at stereotypic locations during early embryogenesis. In both grasshopper and Drosophila, each developing neuroblast acquires an intrinsic capacity for neuronal proliferation in a cell auto...
  10. Embryonic development of the insect central complex: Insights from lineages in the grasshopper andDrosophila

    Arthropod Structure & Development 40(4):334 (2011) PMID 21382507

    The neurons of the insect brain derive from neuroblasts which delaminate from the neuroectoderm at stereotypic locations during early embryogenesis. In both grasshopper and Drosophila, each developing neuroblast acquires an intrinsic capacity for neuronal proliferation in a cell auto...
  11. Developmental expression of neuromodulators in the central complex of the grasshopper Schistocerca gregaria.

    Journal of Morphology 271(12):1509 (2010) PMID 20960464

    The central complex is a major integrative region within the insect brain with demonstrated roles in spatial orientation, the regulation of locomotor behavior, and sound production. In the hemimetabolous grasshopper, the central complex comprises the protocerebral bridge, central body (CB), elli...
  12. Proliferative cell types in embryonic lineages of the central complex of the grasshopper Schistocerca gregaria.

    Cell and Tissue Research 341(2):259 (2010) PMID 20571828

    The central complex of the grasshopper Schistocerca gregaria develops to completion during embryogenesis. A major cellular contribution to the central complex is from the w, x, y, z lineages of the pars intercerebralis, each of which comprises over 100 cells, making them by far the largest in th...
  13. Cell death shapes embryonic lineages of the central complex in the grasshopper Schistocerca gregaria.

    Journal of Morphology 271(8):949 (2010) PMID 20623625

    We have investigated cell death in identified lineages of the central complex in the embryonic brain of the grasshopper Schistocerca gregaria. Progeny from these lineages lie in the pars intercerebralis and direct projections to the protocerebral bridge and then the central body via the w, x, y,...
  14. Multigeneration cross contamination of mail with Bacillus species spores by tumbling.

    Applied and Environmental Microbiology 76(14):4797 (2010) PMID 20511424 PMCID PMC2901736

    In 2001, envelopes loaded with Bacillus anthracis spores were mailed to Senators Daschle and Leahy as well as to the New York Post and NBC News buildings. Additional letters may have been mailed to other news agencies because there was confirmed anthrax infection of employees at these locations....
  15. Multipotent neuroblasts generate a biochemical neuroarchitecture in the central complex of the grasshopper Schistocerca gregaria.

    Cell and Tissue Research 340(1):13 (2010) PMID 20151154

    We have examined the developmental expression of the neuromodulators locustatachykinin, leucokinin-1, allatostatin and serotonin in a subset of lineages (Y, Z) of the central complex in the brain of the grasshopper Schistocerca gregaria. First, we show that all these neuromodulators are expresse...
  16. Successful treatment of metastatic hepatic epithelioid hemangioendothelioma with thalidomide: a case report.

    Journal of Medical Case Reports 4:413 (2010) PMID 21176188 PMCID PMC3022673

    Hepatic epithelioid hemangioendothelioma is a rare malignancy arising from the vascular endothelial cells within the liver. Historically, the disease is characterized as being poorly responsive to both chemotherapy and radiotherapy, with liver resection or transplantation the treatment of choice...
  17. Localization of nitric oxide synthase in the central complex and surrounding midbrain neuropils of the locust Schistocerca gregaria.

    Journal of Comparative Neurology 484(2):206 (2005) PMID 15736229

    Nitric oxide (NO), generated enzymatically by NO synthase (NOS), acts as an important signaling molecule in the nervous systems of vertebrates and invertebrates. In insects, NO has been implicated in development and in various aspects of sensory processing. To understand better the contribution ...
  18. Short term safety and efficacy of an immune enhancing nutrition supplement (IENS) in patients with advanced cirrhosis and HEpatic encephalopathy(He)

    Gastroenterology 124(4):A431 (2003)

  19. The pars intercerebralis of the locust brain: a developmental and comparative study.

    Microscopy Research and Technique 56(3):174 (2002) PMID 11810721

    The anterior midline of the brain, also known as the pars intercerebralis, contains the largest collection of neurosecretory cells in the central nervous system of the grasshopper. In this study, we use immunocytochemical, intracellular staining, and histological methods to establish the ontogen...
  20. A single cell analysis of engrailed expression in the early embryonic brain of the grasshopper Schistocerca gregaria: ontogeny and identity of the secondary headspot cells.

    Arthropod Structure & Development 30(3):207 (2002) PMID 18088956

    The expression pattern of the segment polarity gene engrailed was studied at the single cell level in the protocerebrum of the early embryonic brain of the grasshopper Schistocerca gregaria, the neuromere containing the secondary headspot cells. The engrailed protein is first expressed in the pr...