1. Metalation/functionalization sequences applied to 2-bromo-3-fluoroquinolines

    Tetrahedron 61(3):717 (2005)

    Mono- and disubstituted 2-bromo-3-fluoroquinolines 3 are readily accessible. They can be converted into the 3-fluoroquinoline-2-carboxylic acids 5 by consecutive halogen/metal permutation and into the 2-bromo-3-fluoroquinoline-4-carboxylic acids ...