Modeling of in-use stability for tablets and powders in bottles.
Drug Development and Industrial Pharmacy 42(10):1571 (2016)
A model is presented for determining the time when an active pharmaceutical ingredient in tablets/powders will remain within its specification limits during an in-use period; that is, when a heat-induction sealed bottle is opened for fixed time periods and where tablets are removed at fixed time...
Visible-Light Photoredox Catalyzed Three-Component Cyclization of 2H-Azirines, Alkynyl Bromides, and Molecular Oxygen to Oxazole Skeleton.
Organic Letters 18(15):3646 (2016)
A novel three-component cyclization of 2H-azirines, alkynyl bromides, and molecular oxygen under visible-light photoredox catalysis at room temperature has been developed, which provides a direct approach to a wide range of substituted oxazoles in moderate to good yields.
An Obstructive Sleep Apnea Detection Approach Using a Discriminative Hidden Markov Model From ECG Signals.
Biomedical Engineering, IEEE Transactions on 63(7):1532 (2016)
Obstructive sleep apnea (OSA) syndrome is a common sleep disorder suffered by an increasing number of people worldwide. As an alternative to polysomnography (PSG) for OSA diagnosis, the automatic OSA detection methods used in the current practice mainly concentrate on feature extraction and clas...
One-step fabrication of amino functionalized magnetic graphene oxide composite for uranium(VI) removal.
Journal of Colloid and Interface Science 472:99 (2016)
Amino functionalized magnetic graphene oxide composite (AMGO), a good sorbent for U(VI), was fabricated and characterized. The AMGO was applied as a magnetic sorbent for the U(VI) removal from aqueous solutions. The AMGO can be easily recovered from the solution with the magnetic separation with...
Cancer incidence and mortality in Gansu province, 2012.
Chinese Journal of Cancer Research 28(3):301 (2016)
Population-based cancer registration data in 2012 from all available cancer registries in Gansu province were collected by the Central Cancer Registry of Gansu. The numbers of new cancer cases and cancer deaths in Gansu province with compiled cancer incidence and mortality rates were estimated.
Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia.
Oncotarget 7(18):25208 (2016)
MLL rearrangements occur in myeloid and lymphoid leukemias and are generally associated with a poor prognosis, however this varies depending on the fusion partner. We modeled acute myeloid leukemia (AML) in mice using various MLL fusion proteins (MLL-FPs) and observed significantly different sur...
Lower Serum Levels of Uric Acid in Uterine Fibroids and Fibrocystic Breast Disease Patients in Dongying City, China.
Iranian Journal of Public Health 45(5):596 (2016)
Increasing serum levels of uric acid (SUA) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate SUA. Estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. The study aimed to explore SUA among patients suffering from...
[Association between serum direct bilirubin with metabolic syndrome and its components based on a longitudinal health check-up study].
Zhonghua liu xing bing xue za zhi = Zhonghua li... 37(4):486 (2016)
To investigate the association between serum direct bilirubin (DBIL) with metabolic syndrome (MS) and its components.
A dynamic health check-up cohort study was set up from 2006 to 2011. 5 258 participants who satisfied the two basic rules: 1) being free of MS at the 1(st) health check-up progra...
Dysregulation of the NLRP3 inflammasome complex and related cytokines in patients with multiple myeloma.
Hematology 21(3):144 (2016)
The NLRP3 inflammasome complex, an important regulatory factor of inflammation and cell apoptosis, has attracted considerable attention in the development of tumor. Here, we analyzed the expression and clinical significance of NLRP3 inflammasome complex and related cytokines in patients with mul...
Simultaneous exposure to estrogen and androgen resulted in feminization and endocrine disruption.
Journal of Endocrinology 228(3):205 (2016)
Estrogen, which is synthesized earlier in females than androgen in males, is critical for sex determination in non-mammalian vertebrates. However, it remains unknown that what would happen to the gonadal phenotype if estrogen and androgen were administrated simultaneously. In this study, XY and ...
PFKFB3 Control of Cancer Growth by Responding to Circadian Clock Outputs.
Scientific reports 6:24324 (2016)
Circadian clock dysregulation promotes cancer growth. Here we show that PFKFB3, the gene that encodes for inducible 6-phosphofructo-2-kinase as an essential supporting enzyme of cancer cell survival through stimulating glycolysis, mediates circadian control of carcinogenesis. In patients with to...
Towards universal access to skilled birth attendance: the process of transforming the role of traditional birth attendants in Rural China.
BMC Pregnancy and Childbirth 16(1):58 (2016)
Institution-based childbirth, with the ultimate goal of universal access to skilled birth attendance (SBA), has been selected as a key strategy to reduce the maternal mortality rate in many developing countries. However, the question of how to engage traditional birth attendants (TBAs) in the ad...
The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis.
BioMed Research International 2016:1652417 (2016)
MicroRNAs are involved in many cellular and molecular activities and played important roles in many biological and pathological processes, such as tissue formation, cancer development, diabetes, neurodegenerative diseases, and cardiovascular diseases. Recently, it has been reported that microRNA...
Adherence to ARRIVE Guidelines in Chinese Journal Reports on Neoplasms in Animals.
PLoS ONE 11(5):e0154657 (2016)
The Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines were published in 2010 with the aim of improving the quality of studies involving animals. However, how well Chinese studies involving animal neoplasms adhere to these guidelines has not been assessed.
To evaluate the rep...
Functional characterization of CYP2D6 novel allelic variants identified in the Chinese Han population.
Pharmacogenomics 17(2):119 (2016)
This study was aimed to functionally characterize four novel CYP2D6 alleles identified in Chinese Han population.
CYP2D6 proteins of wild-type and the four novel variants along with CYP2D6.2 and CYP2D6.10 were heterologously expressed in yeast cells and the kinetic parameters were determined.
[Case of myofibril myopathy].
Zhongguo zhen jiu = Chinese acupuncture & moxib... 35(12):1304 (2015)
Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia.
Journal of Molecular and Cellular Cardiology 89(Pt B):185 (2015)
Elevated levels of reactive oxygen species (ROS) in the vascular wall play a key role in the development of neointimal hyperplasia. Nox4-based NADPH oxidase is a major ROS generating enzyme in the vasculature, but its roles in neointimal hyperplasia remain unclear.
Our purpose was to investigate...
[Application of linear stapler in total laryngectomy].
Lin chuang er bi yan hou ke za zhi = Journal of... 29(24):2170 (2015)
Hierarchical Grid-based Multi-People Tracking-by-Detection With Global Optimization.
Image Processing, IEEE Transactions on 24(11):4197 (2015)
We present a hierarchical grid-based, globally optimal tracking-by-detection approach to track an unknown number of targets in complex and dense scenarios, particularly addressing the challenges of complex interaction and mutual occlusion. Frame-by-frame detection is performed by hierarchical li...
Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors.
Reproductive BioMedicine Online 31(5):638 (2015)
The aim of the present study was to elucidate whether the GATA-4/SF-1 signalling pathway is involved in the inhibitory effects of melatonin on testosterone production in both the TM3 Leydig cell line and in C57BL/6J mice. In-vitro experiments demonstrated that melatonin treatment significantly r...