1. IGF1 Promotes Adipogenesis by a Lineage Bias of Endogenous Adipose Stem/Progenitor Cells.

    Stem Cells 33(8):2483 (2015) PMID 26010009 PMCID PMC4509822

    Adipogenesis is essential for soft tissue reconstruction following trauma or tumor resection. We demonstrate that CD31(-) /34(+) /146(-) cells, a subpopulation of the stromal vascular fraction (SVF) of human adipose tissue, were robustly adipogenic. Insulin growth factor-1 (IGF1) promoted a line...
  2. Toxicity of 8-Hydroxyquinoline in Cryprinus carpio Using the Acute Toxicity Test, Hepatase Activity Analysis and the Comet Assay.

    Bulletin of Environmental Contamination and Tox... 95(2):171 (2015) PMID 26067700

    To evaluate the environmental toxicity of 8-hydroxyquinoline (8-HOQ), an important industrial raw material found in China's major ornamental fish, Cryprinus carpio, using the acute toxicity test, hepatase activity analysis and the comet assay. The results indicated that 8-HOQ had significant acu...
  3. Design, Synthesis, and Biological Evaluation of Novel Nonsteroidal Farnesoid X Receptor (FXR) Antagonists: Molecular Basis of FXR Antagonism.

    Chemmedchem 10(7):1184 (2015) PMID 25982493

    Farnesoid X receptor (FXR) plays an important role in the regulation of cholesterol, lipid, and glucose metabolism. Recently, several studies on the molecular basis of FXR antagonism have been reported. However, none of these studies employs an FXR antagonist with nonsteroidal scaffold. On the b...
  4. [Expression of human mutT homologue 1 (hMTH1) and its clinical significance in acute lymphoblastic leukemia].

    Zhonghua xue ye xue za zhi = Zhonghua xueyexue ... 36(6):526 (2015) PMID 26134022

  5. Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis.

    Cell Research 25(6):691 (2015) PMID 26021615 PMCID PMC4456629

    Inappropriate inflammation responses contribute to mortality during sepsis. Through Toll-like receptors (TLRs), reactive oxygen species (ROS) produced by NADPH oxidase could modulate the inflammation responses. Parkinson disease (autosomal recessive, early onset) 7 (Park7) has a cytoprotective r...
  6. Gold-catalyzed cyclotrimerization of arynes for the synthesis of triphenylenes

    Catalysis Communications 65:81 (2015)

    A novel and efficient Au(I)-catalyzed cyclotrimerization of arynes, generated by fluoride-induced elimination of Kobayashi's silylaryl triflates, is described. The reactions led to the formation of triphenylenes in 45–88% yields under mild conditions. © 2015 Elsevier B.V. All rights re...
  7. Gold-catalyzed cyclotrimerization of arynes for the synthesis of triphenylenes

    Catalysis Communications 65:81 (2015)

    A novel and efficient Au(I)-catalyzed cyclotrimerization of arynes, generated by fluoride-induced elimination of Kobayashi's silylaryl triflates, is described. The reactions led to the formation of triphenylenes in 45–88% yields under mild conditions. © 2015 Elsevier B.V. All rights re...
  8. Targeting FoxM1 inhibits proliferation, invasion and migration of nasopharyngeal carcinoma through the epithelial‑to-mesenchymal transition pathway.

    Oncology Reports 33(5):2402 (2015) PMID 25738652

    High expression levels of the forkhead box M1 (FoxM1) transcription factor are associated with metastasis and poor prognosis of malignancies. However, little is known concerning its function in nasopharyngeal carcinoma (NPC). The present study aimed to investigate the impact of FoxM1 inhibition ...
  9. Smokeless tobacco products sold in Massachusetts from 2003 to 2012: trends and variations in brand availability, nicotine contents and design features.

    Tobacco Control 24(3):256 (2015) PMID 24420311

    Sales of smokeless tobacco products have increased in the USA. More than one in eight males in the 12th grade are current users of smokeless tobacco. Surveillance data examining nicotine levels of smokeless tobacco subsequent to 2006 have not been reported in the literature. Data on nicotine lev...
  10. An obstructive sleep apnea detection approach using kernel density classification based on single-lead electrocardiogram.

    Journal of Medical Systems 39(5):47 (2015) PMID 25732075

    Obstructive sleep apnea (OSA) is a common sleep disorder that often remains undiagnosed, leading to an increased risk of developing cardiovascular diseases. Polysomnogram (PSG) is currently used as a golden standard for screening OSA. However, because it is time consuming, expensive and causes d...
  11. An obstructive sleep apnea detection approach using kernel density classification based on single-lead electrocardiogram.

    Journal of Medical Systems 39(5):222 (2015) PMID 25732075

    Obstructive sleep apnea (OSA) is a common sleep disorder that often remains undiagnosed, leading to an increased risk of developing cardiovascular diseases. Polysomnogram (PSG) is currently used as a golden standard for screening OSA. However, because it is time consuming, expensive and causes d...
  12. [Role of LIGHT signal pathway in Chlamydia muridarum urogenital infection in mice].

    Acta Microbiologica Sinica 55(4):492 (2015) PMID 26211324

    To study the role of lymphotoxin-like inducible protein that competes with glycoprotein D for herpesvirus entry on T cells (LIGHT) in the development of protective immunity and pathology during Chlamydia Muridarum urogenital infection in mice. C57BL/6J wild type (wt) and mice deficient in LIGHT ...
  13. The Expression and Role of MEKK3 in Renal Clear Cell Carcinoma.

    Anatomical Record. Part A: Advances in Integrat... 298(4):727 (2015) PMID 25388155

    To explore the relationship between Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3(MEKK3) and cell apoptosis, clinicopathology, and prognosis, we characterize the expression of MEKK3, survivin and stat3 in renal clear cell carcinoma (RCCC). The expressions...
  14. Discovery of new non-steroidal farnesoid X receptor modulators through 3D shape similarity search and structure-based virtual screening.

    Chemical Biology & Drug Design 85(4):481 (2015) PMID 25228339

    As a ligand-activated transcriptional factor, farnesoid X receptor (FXR) has a variety of biological functions, such as biosynthesis of bile acids, metabolism of lipid, and glucose homeostasis, and thus is related to multiple diseases, especially metabolic syndrome. In this study, to discover ne...
  15. Discovery of New Non-Steroidal Farnesoid X Receptor Modulators Through 3D Shape Similarity Search and Structure-Based Virtual Screening.

    Chemical Biology & Drug Design 85(4):481 (2015) PMID 25228339

    As a ligand-activated transcriptional factor, farnesoid X receptor (FXR) has a variety of biological functions, such as biosynthesis of bile acids, metabolism of lipid, and glucose homeostasis, and thus is related to multiple diseases, especially metabolic syndrome. In this study, to discover ne...
  16. FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells.

    Oncotarget 6(8):6310 (2015) PMID 25749036 PMCID PMC4467439

    Epithelial-mesenchymal transition (EMT) plays a fundamental role in cancer metastasis. The ubiquitin ligase FBXW7, a general tumor suppressor in human cancer, has been implicated in diverse cellular processes, however, its role in cholangiocarcinoma (CCA) metastasis has not been identified. Here...
  17. The effects of macrophage-stimulating protein on the migration, proliferation, and collagen synthesis of skin fibroblasts in vitro and in vivo.

    Tissue Engineering, Part A: Tissue Engineering 21(5-6):982 (2015) PMID 25315688

    Macrophage-stimulating protein (MSP), an important cytokine with multiple functions, is highly expressed in adipose-derived stem cells-conditioned medium (ASC-CM). ASCs can effectively promote wound healing through paracrine mechanism, suggesting that MSP may play a critical role in wound healin...
  18. [Delta12-prostaglandinJ2-nano capsule up-regulates growth factor expression and enhances bone regeneration in rats].

    Zhonghua kou qiang yi xue za zhi = Zhonghua kou... 50(3):151 (2015) PMID 26081853

    To investigate the effect of local delivery of delta12-prostaglandinJ2-loaded poly (lactic-co-glycolic acid) (Δ(12)-PGJ2-NC) on growth factors expression and bone formation. Δ(12)-PGJ2-NC was prepared by the emulsion solvent diffusion method. The physical and chemical properties of the nanoparti...
  19. The effects of macrophage-stimulating protein on the migration, proliferation, and collagen synthesis of skin fibroblasts in vitro and in vivo.

    Tissue Engineering, Part A: Tissue Engineering 21(5-6):982 (2015) PMID 25315688

    Macrophage-stimulating protein (MSP), an important cytokine with multiple functions, is highly expressed in adipose-derived stem cells-conditioned medium (ASC-CM). ASCs can effectively promote wound healing through paracrine mechanism, suggesting that MSP may play a critical role in wound healin...
  20. HGF expression induced by HIF-1α promote the proliferation and tube formation of endothelial progenitor cells.

    Cell Biology International 39(3):310 (2015) PMID 25339500

    Hypoxia-inducible factor-1α (HIF-1α) and hepatocyte growth factor (HGF) play important roles in postnatal neovascularization. However, the interaction of these two pathways is not fully understood. The present study utilized CoCl2 treated-endothelial progenitor cells (EPCs) (EPCs exposure to CoC...