1. Three-dimensional polycaprolactone-hydroxyapatite scaffolds combined with bone marrow cells for cartilage tissue engineering.

    Journal of Biomaterials Applications 30(2):160 (2015) PMID 25766036

    The goal of this study was to investigate the chondrogenic potential of three-dimensional polycaprolactone-hydroxyapatite (PCL-HA) scaffolds loaded with bone marrow cells in vitro and the effect of PCL-HA scaffolds on osteochondral repair in vivo. Here, bone marrow was added to the prepared PCL-...
  2. Gd-Metallofullerenol Nanomaterial Suppresses Pancreatic Cancer Metastasis by Inhibiting the Interaction of Histone Deacetylase 1 and Metastasis-Associated Protein 1.

    ACS Nano 9(7):6826 (2015) PMID 26083726

    The treatment of pancreatic cancer frequently fails due to local recurrence and hepatic metastasis. Our previous study found that Gd@C82(OH)22 can suppress pancreatic cancer by inhibiting MMP-2/9 expression. In this study, we further explored the epigenetic mechanism of Gd@C82(OH)22 in human pan...
  3. Composite scaffolds composed of bone marrow mesenchymal stem cell-derived extracellular matrix and marrow clots promote marrow cell retention and proliferation.

    Journal of Biomedical Materials Research, Part A 103(7):2374 (2015) PMID 25410417

    Various biomaterials have been investigated in attempts to improve the mechanical stability of marrow clots derived from microfracture to obtain repaired tissue closely resembling hyaline cartilage. The goal of this study was to investigate the retention, adhesion, proliferation, and cartilage e...
  4. Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity.

    ACS Nano 9(6):6532 (2015) PMID 25994391

    To predict potential medical value or toxicity of nanoparticles (NPs), it is necessary to understand the chemical transformation during intracellular processes of NPs. However, it is a grand challenge to capture a high-resolution image of metallic NPs in a single cell and the chemical informatio...
  5. A disintegrin and metallproteinase 15 knockout decreases migration of fibroblast-like synoviocytes and inflammation in rheumatoid arthritis.

    Molecular Medicine Reports 11(6):4389 (2015) PMID 25650586

    The aim of the present study was to determine whether the expression of A disintegrin and metallproteinase 15 (ADAM15) affected the inflammatory conditions and cell migration in human fibroblast‑like synoviocytes (FLSs) in a rat model of rheumatoid arthritis (RA). The expression of ADAM15 in FLS...
  6. TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction.

    Anesthesiology 122(6):1338 (2015) PMID 25815455

    Hypoxic pulmonary vasoconstriction (HPV) is critically important in regionally heterogeneous lung diseases by directing blood toward better-oxygenated lung units, yet the molecular mechanism of HPV remains unknown. Transient receptor potential (TRP) channels are a large cation channel family tha...
  7. The Atmospheric Oxidation Mechanism of Benzyl Alcohol Initiated by OH Radicals: The Addition Channels.

    ChemPhysChem 16(7):1542 (2015) PMID 25765371

    Benzyl alcohol (BA) is present in indoor atmospheres, where it reacts with OH radicals and undergoes further oxidation. A theoretical study is carried out to elucidate the reaction mechanism and to identify the main products of the oxidation of BA that is initiated by OH radicals. The reaction i...
  8. Technetium-99m-labeled annexin V imaging for detecting prosthetic joint infection in a rabbit model.

    Journal of Biomedical Research 29(3):224 (2015) PMID 26060446 PMCID PMC4449490

    Accurate and timely diagnosis of prosthetic joint infection is essential to initiate early treatment and achieve a favorable outcome. In this study, we used a rabbit model to assess the feasibility of technetium-99m-labeled annexin V for detecting prosthetic joint infection. Right knee arthropla...
  9. Gq signaling causes glomerular injury by activating TRPC6.

    Journal of Clinical Investigation 125(5):1913 (2015) PMID 25844902 PMCID PMC4463190

    Familial forms of focal segmental glomerulosclerosis (FSGS) have been linked to gain-of-function mutations in the gene encoding the transient receptor potential channel C6 (TRPC6). GPCRs coupled to Gq signaling activate TRPC6, suggesting that Gq-dependent TRPC6 activation underlies glomerular di...
  10. Octopamine mediates starvation-induced hyperactivity in adult Drosophila.

    PNAS 112(16):5219 (2015) PMID 25848004 PMCID PMC4413307

    Starved animals often exhibit elevated locomotion, which has been speculated to partly resemble foraging behavior and facilitate food acquisition and energy intake. Despite its importance, the neural mechanism underlying this behavior remains unknown in any species. In this study we confirmed an...
  11. A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS.

    Journal of the American Society of Nephrology 26(4):831 (2015) PMID 25145932 PMCID PMC4378093

    FSGS is a clinical disorder characterized by focal scarring of the glomerular capillary tuft, podocyte injury, and nephrotic syndrome. Although idiopathic forms of FSGS predominate, recent insights into the molecular and genetic causes of FSGS have enhanced our understanding of disease pathogene...
  12. Chondrogenic regeneration using bone marrow clots and a porous polycaprolactone-hydroxyapatite scaffold by three-dimensional printing.

    Tissue Engineering, Part A: Tissue Engineering 21(7-8):1388 (2015) PMID 25530453 PMCID PMC4394873

    Scaffolds play an important role in directing three-dimensional (3D) cartilage regeneration. Our recent study reported the potential advantages of bone marrow clots (MC) in promoting extracellular matrix (ECM) scaffold chondrogenic regeneration. The aim of this study is to build a new scaffold f...
  13. Metformin sensitizes hepatocellular carcinoma to arsenic trioxide-induced apoptosis by downregulating Bcl2 expression.

    Tumor Biology 36(4):2957 (2015) PMID 25492486

    Hepatocellular carcinoma (HCC) is a highly malignant tumor that can evolve rapidly to acquire resistance to conventional chemotherapies. Arsenic trioxide (ATO) is a traditional Asian medicine, and a phase II study has shown that treatment with ATO alone was not effective against HCC. Bcl2 is an ...
  14. CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.

    PNAS 112(13):E1614 (2015) PMID 25829545 PMCID PMC4386337

    Hypoxic pulmonary vasoconstriction (HPV) optimizes pulmonary ventilation-perfusion matching in regional hypoxia, but promotes pulmonary hypertension in global hypoxia. Ventilation-perfusion mismatch is a major cause of hypoxemia in cystic fibrosis. We hypothesized that cystic fibrosis transmembr...
  15. Capillary-bridge-derived particles with negative Gaussian curvature.

    PNAS 112(9):2664 (2015) PMID 25730873 PMCID PMC4352790

    We report the preparation of millimeter-scale particles by thermal polymerization of liquid monomer capillary bridges to form catenoid-shaped particles that exhibit negative Gaussian curvature. The shape of the capillary bridges and resulting particles can be finely tuned using several addressab...
  16. Capillary-bridge-derived particles with negative Gaussian curvature.

    PNAS 112(9):2664 (2015) PMID 25730873 PMCID PMC4352790

    We report the preparation of millimeter-scale particles by thermal polymerization of liquid monomer capillary bridges to form catenoid-shaped particles that exhibit negative Gaussian curvature. The shape of the capillary bridges and resulting particles can be finely tuned using several addressab...
  17. Methyl-CpG binding domain 4 tagging polymorphisms and esophageal cancer risk in a Chinese population.

    European Journal of Cancer Prevention 24(2):100 (2015) PMID 25162968

    In 2009, esophageal cancer was recorded as the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China. Esophageal squamous cell carcinoma (ESCC) accounts for more than 90% of esophageal cancers. Genetic factors might play an important role in the carci...
  18. [Initial comparison of regional ischemic preconditioning and hemi-hepatic vascular inflow occlusion in resection of hepatocellular carcinoma].

    Zhonghua zhong liu za zhi [Chinese journal of o... 37(3):186 (2015) PMID 25975786

    To evaluate preliminarily the clinical efficacy of two types of hepatic inflow occlusion in hepatectomy for hepatocellular carcinoma (HCC). A total of 54 patients with HCC who underwent hepatectomy were divided into two groups: RIP group (regional ischemic preconditioning with continuous clampin...
  19. Fast intracellular dissolution and persistent cellular uptake of silver nanoparticles in CHO-K1 cells: implication for cytotoxicity.

    Nanotoxicology 9:181 (2015) PMID 24738617

    Toxicity of silver nanoparticles (Ag NPs) has been reported both in vitro and in vivo. However, the intracellular stability and chemical state of Ag NPs are still not very well studied. In this work, we systematically investigated the cellular uptake pathways, intracellular dissolution and chemi...
  20. Methyl-CpG binding domain 4 tagging polymorphisms and esophageal cancer risk in a Chinese population.

    European Journal of Cancer Prevention 24(2):100 (2015) PMID 25162968

    In 2009, esophageal cancer was recorded as the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China. Esophageal squamous cell carcinoma (ESCC) accounts for more than 90% of esophageal cancers. Genetic factors might play an important role in the carci...