1. An S-Acylation Switch of Conserved G Domain Cysteines Is Required for Polarity Signaling by ROP GTPases

    Current Biology 25(21):2875 (2015)

  2. An S-acylation switch of conserved G domain cysteines is required for polarity signaling by ROP GTPases.

    Current Biology 20(10):914 (2010) PMID 20451389

    Rho GTPases are master regulators of cell polarity. For their function, Rhos must associate with discrete plasma membrane domains. Rho of Plants (ROPs) or RACs comprise a single family. Prenylation and S-acylation of hypervariable domain cysteines of Ras and Rho GTPases are required for their fu...
  3. A rho scaffold integrates the secretory system with feedback mechanisms in regulation of auxin distribution.

    PLoS Biology 8(1):e1000282 (2010) PMID 20098722 PMCID PMC2808208

    Development in multicellular organisms depends on the ability of individual cells to coordinate their behavior by means of small signaling molecules to form correctly patterned tissues. In plants, a unique mechanism of directional transport of the signaling molecule auxin between cells connects ...
  4. A Novel ROP/RAC Effector Links Cell Polarity, Root-Meristem Maintenance, and Vesicle Trafficking

    Current Biology 17(11):947 (2007)

    ROP/RAC GTPases are master regulators of cell polarity in plants, implicated in the regulation of diverse signaling cascades including cytoskeleton organization, vesicle trafficking, and Ca2+ gradients [1–8]. The involvement of ROPs in differentiation processes is yet unknown. Here we ...
  5. A Novel ROP/RAC effector links cell polarity, root-meristem maintenance, and vesicle trafficking.

    Current Biology 17(11):947 (2007) PMID 17493810

    ROP/RAC GTPases are master regulators of cell polarity in plants, implicated in the regulation of diverse signaling cascades including cytoskeleton organization, vesicle trafficking, and Ca(2+) gradients [1-8]. The involvement of ROPs in differentiation processes is yet unknown. Here we show the...
  6. Activation status-coupled transient S acylation determines membrane partitioning of a plant Rho-related GTPase.

    Molecular and Cellular Biology 27(6):2144 (2007) PMID 17242203 PMCID PMC1820497

    ROPs or RACs are plant Rho-related GTPases implicated in the regulation of a multitude of signaling pathways that function at the plasma membrane by virtue of posttranslational lipid modifications. The relationship between ROP activation status and membrane localization has not been established....