Synergistic analgesic effect of propofol-alfentanil combination through detecting the inhibition of cAMP signal pathway.
Journal of Pharmacy and Pharmacology 68(9):1170 (2016)
The study aims to investigate the possible mechanism of the synergistic analgesic effect of propofol-alfentanil combination.
The synergistic analgesic effects of propofol-alfentanil combination in Sprague-Dawley (SD) rats were analysed through the von Frey test. Then, we examined the activity of...
The electronic structure of Au25 clusters: between discrete and continuous.
Nanoscale 8(31):14711 (2016)
Here, an approach based on synchrotron resonant photoemission is employed to explore the transition between quantization and hybridization of the electronic structure in atomically precise ligand-stabilized nanoparticles. While the presence of ligands maintains quantization in Au25 clusters, the...
Intriguing Morphology Evolution from Noncrosslinked Poly(tert-butyl acrylate) Seeds with Polar Functional Groups in Soap-Free Emulsion Polymerization of Styrene.
Langmuir 32(31):7829 (2016)
Herein, we demonstrate a facile approach to prepare anisotropic poly(tert-butyl acrylate)/polystyrene (PtBA/PS) composite particles with controllable morphologies by soap-free seeded emulsion polymerization (SSEP). In the first step, noncrosslinked PtBA seeds with self-stabilizing polar function...
Four new lanthanide-organic frameworks: selective luminescent sensing and magnetic properties.
Dalton Transactions (Print Edition) 45(32):12800 (2016)
Four new isostructural lanthanide-organic frameworks, [Ln(L)(H2O)2]·H2O·CH3CN (1-Ln) (Ln = Eu, Tb, Dy, and Gd), have been successfully synthesized via solvothermal reactions with a semi-rigid V-shaped multicarboxylate ligand 2-(2',4'-dicarboxylphenoxy) benzoic acid (H3L) and Ln(NO3)3·6H2O. 1-Ln ...
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Angewandte Chemie. International edition in Eng... 55(33):9601 (2016)
Glycogen synthase kinase-3 (GSK-3) regulates multiple cellular processes in diabetes, oncology, and neurology. N-(3-(1H-1,2,4-triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide (PF-04802367 or PF-367) has been identified as a highly potent inhibitor, which is among the most s...
Aberrant structural and functional connectivity in the salience network and central executive network circuit in schizophrenia.
Neuroscience Letters 627:178 (2016)
Consistent structural and functional abnormities have been detected in the salience network (SN) and the central-executive network (CEN) in schizophrenia. SN, known for its critical role in switching CEN and default-mode network (DMN) during cognitively demanding tasks, is proved to show aberran...
The investigation of different pollutants and operation processes on sludge toxicity in sequencing batch bioreactors.
Environmental Technology (Cranfield, UK) 37(16):2048 (2016)
The influence of different target pollutants and operation modes in sequencing batch bioreactors (SBRs) on sludge toxicity was compared in this study. Sludge toxicity was characterized by the inhibiting luminosity through using luminescent bacterium Photobacterium phosphoreum (P. phosphoreum) du...
Characterization of interaction property of multi-components in Gardenia jasminoides with aldose reductase by microdialysis combined with liquid chromatography coupled to mass spectrometry.
Rapid Communications in Mass Spectrometry 30 Suppl 1:87 (2016)
An application of microdialysis sampling for evaluation of the interaction property of small molecules to macromolecules is presented. Microdialysis combined with liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry (LC/QTOF-MS/MS) was established for the purpose o...
Proteasome inhibitor MG132 potentiates TRAIL-induced apoptosis in gallbladder carcinoma GBC-SD cells via DR5-dependent pathway.
Oncology Reports 36(2):845 (2016)
TRAIL is a tumor-selective apoptosis-inducing cytokine playing a vital role in the surveillance and elimination of some tumor cells. However, some tumors are resistant to TRAIL treatment. Proteasome inhibitor MG132 exhibits anti-proliferative and pro-apoptotic properties in many tumors. In this ...
Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation.
Nature Genetics 48(8):947 (2016)
The snub-nosed monkey genus Rhinopithecus includes five closely related species distributed across altitudinal gradients from 800 to 4,500 m. Rhinopithecus bieti, Rhinopithecus roxellana, and Rhinopithecus strykeri inhabit high-altitude habitats, whereas Rhinopithecus brelichi and Rhinopithecus ...
Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model.
FEBS Journal 283(15):2836 (2016)
Paclitaxel is the most commonly used chemotherapeutic agent in breast cancer treatment. In addition to its well-known cytotoxic effects, recent studies have shown that paclitaxel has tumor-supportive activities. Importantly, paclitaxel levels are not maintained at the effective concentration thr...
Applicability of the Chinese version of the 16-item Prodromal Questionnaire (CPQ-16) for identifying attenuated psychosis syndrome in a college population.
Early Intervention In Psychiatry 10(4):308 (2016)
The aim of this study was to examine the reliability, validity, sensitivity and specificity of the Chinese version of the 16-item Prodromal Questionnaire (CPQ-16) for identifying attenuated psychosis syndrome (APS) in a college population.
The participants were recruited from a university. Five ...
Multivitamin use and the risk of hypertension in a prospective cohort study of women.
Journal of Hypertension 34(8):1513 (2016)
Despite the widespread use of multivitamin supplements, little is known regarding their effects on blood pressure (BP) and the development of hypertension. We, therefore, sought to prospectively investigate how multivitamin use was associated with incident hypertension among middle-aged and olde...
Synthesis of mimic molecularly imprinted ordered mesoporous silica adsorbent by thermally reversible semicovalent approach for pipette-tip solid-phase extraction-liquid chromatography fluorescence determination of estradiol in milk.
Journal of chromatography. A 1456:58 (2016)
A mimic molecularly imprinted ordered mesoporous silica (MIOMS) adsorbent was prepared utilizing a thermally reversible semicovalent approach. The thermally reversible covalent template-monomer complex was firstly synthesized by employing 4,4'-sulfonyldiphenol (BPS) and (3-isocyanatopropyl) trie...
Generation and manipulation of super-resolution spherical magnetization chains.
Applied Optics 55(21):5783 (2016)
Based on the inverse Faraday effect, the light-induced magnetization field distributions are investigated for a 4π tight focusing configuration with azimuthally polarized beams. It is found that a superlong (16λ) magnetization chain, composed of 19 subwavelength (0.44λ) spherical spots with long...
Local Fine Structural Insight into Mechanism of Electrochemical Passivation of Titanium.
ACS Applied Materials & Interfaces 8(28):18608 (2016)
Electrochemically formed passive film on titanium in 1.0 M H2SO4 solution and its thickness, composition, chemical state, and local fine structure are examined by Auger electron spectroscopy (AES), X-ray photoelectron spectroscopy (XPS), and X-ray absorption fine structure. AES analysis reveals ...
Fabrication of Highly Sensitive and Stable Hydroxylamine Electrochemical Sensor Based on Gold Nanoparticles and Metal-Metalloporphyrin Framework Modified Electrode.
ACS Applied Materials & Interfaces 8(28):18173 (2016)
This paper describes the immobilization of gold nanoparticles on metal-metalloporphyrin frameworks (AuNPs/MMPF-6(Fe)) through electrostatic adsorption. The composites were characterized by powder X-ray diffraction, zeta potential, transmission electron microscopy, electrochemical impedance spect...
Stimuli-Responsive Layer-by-Layer Tellurium-Containing Polymer Films for the Combination of Chemotherapy and Photodynamic Therapy.
ACS Applied Materials & Interfaces 8(26):17004 (2016)
Tellurium-containing photoresponsive polyelectrolyte multilayer films were fabricated by layer-by-layer assembly of a tellurium-containing polymer, photosensitizer, and poly(styrenesulfonate). The resulting films were investigated by UV/vis spectroscopy, XPS, EPR, and fluorescence spectroscopy. ...
Fe/Ni Metal-Organic Frameworks and Their Binder-Free Thin Films for Efficient Oxygen Evolution with Low Overpotential.
ACS Applied Materials & Interfaces 8(26):16736 (2016)
Multivariate metal-organic frameworks with active Fe/Ni building blocks that are spatially arranged in an open structure are synthesized and explored for oxygen evolution reaction. The heterogeneity and porosity of this system prove to show synergy effect and give low onset overpotential at 170 ...
Two Isostructural Metal-Organic Frameworks Directed by the Different Center Metal Ions, Exhibiting the Ferrimagnetic Behavior and Slow Magnetic Relaxation.
Inorganic Chemistry 55(13):6592 (2016)
Two 3D isostructural metal-organic frameworks with 1D ferrimagnetic chains, formulated as [M3(L)(μ3-OH)2(H2O)4] [H4L = (1,1':4',1″-terphenyl)-2',3,3″,5'-tetracarboxylic acid, where M = Mn for 1 and Co for 2], have been successfully synthesized by employing different center metal ions and a multi...