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  1. A 400,000-year-old mitochondrial genome questions phylogenetic relationships amongst archaic hominins: using the latest advances in ancient ...

    Bioessays 36(6):598 (2014) PMID 24706482

    By combining state-of-the-art approaches in ancient genomics, Meyer and co-workers have reconstructed the mitochondrial sequence of an archaic hominin that lived at Sierra de Atapuerca, Spain about 400,000 years ago. This achievement follows recent advances in molecular anthropology that delivered t...
  2. DNA from extinct giant lemurs links archaeolemurids to extant indriids.

    BMC Evolutionary Biology 8:121 (2008) PMID 18442367 PMCID PMC2386821

    We therefore used ancient DNA technology to address the phylogenetic status of the two archaeolemurid genera (Archaeolemur and Hadropithecus). Despite poor DNA preservation conditions in subtropical environments, we managed to recover 94- to 539-bp sequences for two mitochondrial genes among 5 subfo...
  3. Revisiting Neandertal diversity with a 100,000 year old mtDNA sequence.

    Current Biology 16(11):R400 (2006) PMID 16753548

  4. Ancient DNA analysis reveals woolly rhino evolutionary relationships.

    Molecular Phylogenetics and Evolution 28(3):485 (2003) PMID 12927133

    We have sequenced the entire 12S rRNA and partial cytochrome b (cyt b) genes of one 60-70,000-year-old sample, and partial 12S rRNA and cyt b sequences of two 40-45,000-year-old samples of the extinct woolly rhinoceros (Coelodonta antiquitatis). Based on these two mitochondrial markers, phylogenetic...
  5. The microcephalin ancestral allele in a Neanderthal individual.

    PLoS ONE 5(5):e10648 (2010) PMID 20498832 PMCID PMC2871044

    We report the first PCR amplification and high-throughput sequencing of nuclear DNA at the microcephalin (MCPH1) locus from Neanderthal individual from Mezzena Rockshelter (Monti Lessini, Italy). We show that a well-preserved Neanderthal fossil dated at approximately 50,000 years B.P., was homozygou...
  6. Evolution. An epigenetic window into the past?

    Science 345(6196):511 (2014) PMID 25082684

  7. Rodents of the Caribbean: origin and diversification of hutias unravelled by next-generation museomics.

    Biology Letters 10(7) (2014) PMID 25115033 PMCID PMC4126619

    We used target enrichment and next-generation sequencing of mitochondrial and nuclear genes to infer the phylogenetic relationships of hutias, estimate their divergence ages, and understand their mode of dispersal in the Greater Antilles.We found that Capromyidae are nested within Echimyidae (spiny...
  8. Ancient DNA analysis reveals divergence of the cave bear,Ursus spelaeus, and brown bear,Ursus arctos, lineages

    Current Biology 11(3):200 (2001)

    We previously amplified a short DNA fragment of the mitochondrial DNA control region (mt control region) of a 40,000-year-old Ursus spelaeus sample [4]. In this paper, we describe the DNA analysis of two mtDNA regions, the control region and the cytochrome b gene. Control region sequences were obtai...
  9. Characterization of ancient and modern genomes by SNP detection and phylogenomic and metagenomic analysis using PALEOMIX.

    Nature Protocols 9(5):1056 (2014) PMID 24722405

    We present PALEOMIX (, a flexible and user-friendly pipeline applicable to both modern and ancient genomes, which largely automates the in silico analyses behind whole-genome resequencing. Starting with next-generation sequencing reads, PALEOMIX carries...
  10. Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse.

    Nature 499(7456):74 (2013) PMID 23803765

    We present a 1.12-times coverage draft genome from a horse bone recovered from permafrost dated to approximately 560-780 thousand years before present (kyr BP). Our data represent the oldest full genome sequence determined so far by almost an order of magnitude. For comparison, we sequenced the geno...