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  1. Neanderthals in central Asia and Siberia.

    Nature 449(7164):902 (2007) PMID 17914357

    We determined mitochondrial DNA (mtDNA) sequences from hominid remains found in Uzbekistan and in the Altai region of southern Siberia. Here we show that the DNA sequences from these fossils fall within the European Neanderthal mtDNA variation. Thus, the geographic range of Neanderthals is likely to...
  2. A comparative study of ancient sedimentary DNA, pollen and macrofossils from permafrost sediments of northern Siberia reveals long-term vege...

    Molecular Ecology 21(8):1989 (2012) PMID 22590727

    We conducted a comparative survey of 18 ancient permafrost samples spanning the Late Pleistocene (46-12.5 thousand years ago), from the Taymyr Peninsula in northern Siberia. The results show that pollen, macrofossils and sedaDNA are complementary rather than overlapping and, in combination, reveal m...
  3. Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins.

    Journal of Proteome Research 11(2):917 (2012) PMID 22103443

    We used high-sensitivity, high-resolution tandem mass spectrometry to shotgun sequence ancient protein remains extracted from a 43 000 year old woolly mammoth ( Mammuthus primigenius ) bone preserved in the Siberian permafrost. For the first time, 126 unique protein accessions, mostly low-abundance...
  4. A 400,000-year-old mitochondrial genome questions phylogenetic relationships amongst archaic hominins: using the latest advances in ancient ...

    Bioessays 36(6):598 (2014) PMID 24706482

    By combining state-of-the-art approaches in ancient genomics, Meyer and co-workers have reconstructed the mitochondrial sequence of an archaic hominin that lived at Sierra de Atapuerca, Spain about 400,000 years ago. This achievement follows recent advances in molecular anthropology that delivered t...
  5. True single-molecule DNA sequencing of a pleistocene horse bone.

    Genome Research 21(10):1705 (2011) PMID 21803858 PMCID PMC3202287

    We report the results of the first "true single molecule sequencing" of ancient DNA. We generated 115.9 Mb and 76.9 Mb of DNA sequences from a permafrost-preserved Pleistocene horse bone using the Helicos HeliScope and Illumina GAIIx platforms, respectively. We find that the percentage of endogenous...
  6. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans.

    Nature 505(7481):87 (2014) PMID 24256729 PMCID PMC4105016

    We sequence the draft genome of an approximately 24,000-year-old individual (MA-1), from Mal'ta in south-central Siberia, to an average depth of 1×. To our knowledge this is the oldest anatomically modern human genome reported to date. The MA-1 mitochondrial genome belongs to haplogroup U, which has...
  7. Improving the performance of true single molecule sequencing for ancient DNA.

    BMC Genomics 13(1):177 (2012) PMID 22574620 PMCID PMC3430569

    We aim at improving even further the performance of tSMS for ancient DNA by testing two novel tSMS template preparation methods for Pleistocene bone fossils, namely oligonucleotide spiking and treatment with DNA phosphatase. We found that a significantly larger fraction of the horse genome could be...
  8. Improving ancient DNA read mapping against modern reference genomes.

    BMC Genomics 13:178 (2012) PMID 22574660 PMCID PMC3468387

    We compare different computational methods for improving the accuracy and sensitivity of aDNA sequence identification, based on shotgun sequencing reads recovered from Pleistocene horse extracts using Illumina GAIIx and Helicos Heliscope platforms. We show that the performance of the Burrows Wheeler...
  9. Whole-genome analyses resolve early branches in the tree of life of modern birds.

    Science 346(6215):1320 (2014) PMID 25504713

    We performed a genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves using phylogenomic methods created to handle genome-scale data. We recovered a highly resolved tree that confirms previously controversial sister or close relationships. We identified the first diverge...
  10. Species-specific responses of Late Quaternary megafauna to climate and humans.

    Nature 479(7373):359 (2011) PMID 22048313 PMCID PMC4070744

    We use ancient DNA, species distribution models and the human fossil record to elucidate how climate and humans shaped the demographic history of woolly rhinoceros, woolly mammoth, wild horse, reindeer, bison and musk ox. We show that climate has been a major driver of population change over the pas...