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  1. An Aboriginal Australian genome reveals separate human dispersals into Asia.

    Science 334(6052):94 (2011) PMID 21940856 PMCID PMC3991479

    We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aborigin...
  2. Ancient DNA and human evolution.

    Journal of Human Evolution 79:1 (2015) PMID 25619123

  3. Surprising migration and population size dynamics in ancient Iberian brown bears (Ursus arctos).

    PNAS 105(13):5123 (2008) PMID 18347332 PMCID PMC2278212

    We have sequenced mitochondrial DNA (mtDNA) from ancient Iberian bear remains and analyzed them as a serial dataset, monitoring changes in diversity and occurrence of European haplogroups over time. Using these data, we show that the Iberian bear population has experienced a dynamic, recent evolutio...
  4. A 400,000-year-old mitochondrial genome questions phylogenetic relationships amongst archaic hominins: using the latest advances in ancient ...

    Bioessays 36(6):598 (2014) PMID 24706482

    By combining state-of-the-art approaches in ancient genomics, Meyer and co-workers have reconstructed the mitochondrial sequence of an archaic hominin that lived at Sierra de Atapuerca, Spain about 400,000 years ago. This achievement follows recent advances in molecular anthropology that delivered t...
  5. True single-molecule DNA sequencing of a pleistocene horse bone.

    Genome Research 21(10):1705 (2011) PMID 21803858 PMCID PMC3202287

    We report the results of the first "true single molecule sequencing" of ancient DNA. We generated 115.9 Mb and 76.9 Mb of DNA sequences from a permafrost-preserved Pleistocene horse bone using the Helicos HeliScope and Illumina GAIIx platforms, respectively. We find that the percentage of endogenous...
  6. Mitogenome sequencing reveals shallow evolutionary histories and recent divergence time between morphologically and ecologically distinct Eu...

    Molecular Ecology 21(11):2727 (2012) PMID 22509795

    We explored an alternate use of such data to recover relationships and population history of closely related lineages with a shallow evolutionary history. Using a GS-FLX platform, we sequenced 106 mitogenomes from the Coregonus lavaretus (Europe) and Coregonus clupeaformis (North America) species co...
  7. Out of the Pacific and back again: insights into the matrilineal history of Pacific killer whale ecotypes.

    PLoS ONE 6(9):e24980 (2011) PMID 21949818 PMCID PMC3176785

    We apply further phylogenetic and coalescent analyses to partitioned mitochondrial genome sequences to better resolve the pattern of past radiations in this species. Our phylogenetic reconstructions indicate that in the North Pacific, sympatry between the maternal lineages that make up each ecotype...
  8. Ancient and modern environmental DNA.

    Philosophical Transactions of the Royal Society... 370(1660):20130383 (2015) PMID 25487334 PMCID PMC4275890

    We provide a review of the field. © 2014 The Author(s) Published by the Royal Society. All rights reserved....
  9. A comparative study of ancient sedimentary DNA, pollen and macrofossils from permafrost sediments of northern Siberia reveals long-term vege...

    Molecular Ecology 21(8):1989 (2012) PMID 22590727

    We conducted a comparative survey of 18 ancient permafrost samples spanning the Late Pleistocene (46-12.5 thousand years ago), from the Taymyr Peninsula in northern Siberia. The results show that pollen, macrofossils and sedaDNA are complementary rather than overlapping and, in combination, reveal m...
  10. Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins.

    Journal of Proteome Research 11(2):917 (2012) PMID 22103443

    We used high-sensitivity, high-resolution tandem mass spectrometry to shotgun sequence ancient protein remains extracted from a 43 000 year old woolly mammoth ( Mammuthus primigenius ) bone preserved in the Siberian permafrost. For the first time, 126 unique protein accessions, mostly low-abundance...