1. Radiation combined injury models to study the effects of interventions and wound biomechanics.

    Radiation Research 182(6):640 (2014) PMID 25409125

    In the event of a nuclear detonation, a considerable number of projected casualties will suffer from combined radiation exposure and burn and/or wound injury. Countermeasure assessment in the setting of radiation exposure combined with dermal injury is hampered by a lack of animal models in whic...
  2. Radiation combined injury models to study the effects of interventions and wound biomechanics.

    Radiation Research 182(6):640 (2014) PMID 25409125

    In the event of a nuclear detonation, a considerable number of projected casualties will suffer from combined radiation exposure and burn and/or wound injury. Countermeasure assessment in the setting of radiation exposure combined with dermal injury is hampered by a lack of animal models in whic...
  3. Radiation combined injury models to study the effects of interventions and wound biomechanics.

    Radiation Research 182(6):640 (2014) PMID 25409125

    In the event of a nuclear detonation, a considerable number of projected casualties will suffer from combined radiation exposure and burn and/or wound injury. Countermeasure assessment in the setting of radiation exposure combined with dermal injury is hampered by a lack of animal models in whic...
  4. Radiation combined injury models to study the effects of interventions and wound biomechanics.

    Radiation Research 182(6):640 (2014) PMID 25409125

    In the event of a nuclear detonation, a considerable number of projected casualties will suffer from combined radiation exposure and burn and/or wound injury. Countermeasure assessment in the setting of radiation exposure combined with dermal injury is hampered by a lack of animal models in whic...
  5. Neurogenesis, exercise, and cognitive late effects of pediatric radiotherapy.

    Neural Plasticity 2013:698528 (2013) PMID 23691370 PMCID PMC3649702

    Brain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment. RT is effective for tumor eradication, and survival rates are high. However, RT damages the brain and disrupts ongoing developmental processes, resulting in debilitating cognitive "late" effe...
  6. Neurogenesis, exercise, and cognitive late effects of pediatric radiotherapy.

    Neural Plasticity 2013:698528 (2013) PMID 23691370 PMCID PMC3649702

    Brain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment. RT is effective for tumor eradication, and survival rates are high. However, RT damages the brain and disrupts ongoing developmental processes, resulting in debilitating cognitive "late" effe...
  7. Vascular-targeted photothermal therapy of an orthotopic murine glioma model.

    Nanomedicine 7(8):1133 (2012) PMID 22583571

    To develop nanoshells for vascular-targeted photothermal therapy of glioma. The ability of nanoshells conjugated to VEGF and/or poly(ethylene glycol) (PEG) to thermally ablate VEGF receptor-2-positive endothelial cells upon near-infrared laser irradiation was evaluated in vitro. Subsequent in vi...
  8. Vascular-targeted photothermal therapy of an orthotopic murine glioma model.

    Nanomedicine 7(8):1133 (2012) PMID 22583571

    To develop nanoshells for vascular-targeted photothermal therapy of glioma. The ability of nanoshells conjugated to VEGF and/or poly(ethylene glycol) (PEG) to thermally ablate VEGF receptor-2-positive endothelial cells upon near-infrared laser irradiation was evaluated in vitro. Subsequent in vi...
  9. Effects of irradiation on brain vasculature using an in situ tumor model.

    International Journal of Radiation Oncology*Bio... 82(3):1075 (2012) PMID 22197233 PMCID PMC3554234

    Damage to normal tissue is a limiting factor in clinical radiotherapy (RT). We tested the hypothesis that the presence of tumor alters the response of normal tissues to irradiation using a rat in situ brain tumor model. Intravital microscopy was used with a rat cranial window to assess the in si...
  10. Effects of irradiation on brain vasculature using an in situ tumor model.

    International Journal of Radiation Oncology*Bio... 82(3):1075 (2012) PMID 22197233 PMCID PMC3554234

    Damage to normal tissue is a limiting factor in clinical radiotherapy (RT). We tested the hypothesis that the presence of tumor alters the response of normal tissues to irradiation using a rat in situ brain tumor model. Intravital microscopy was used with a rat cranial window to assess the in si...
  11. Effects of Irradiation on Brain Vasculature Using anIn SituTumor Model

    International Journal of Radiation Oncology*Bio... 82(3):1075 (2012)

    Purpose Damage to normal tissue is a limiting factor in clinical radiotherapy (RT). We tested the hypothesis that the presence of tumor alters the response of normal tissues to irradiation using a rat in situ brain tumor model.
  12. Effect of radiation on the penetration of irinotecan in rat cerebrospinal fluid.

    Cancer Chemotherapy and Pharmacology 68(3):721 (2011) PMID 21161529

    Anticancer agents are useful for treating brain tumors, but sub therapeutic concentrations due to decreased blood-brain barrier (BBB) penetration limit their effectiveness. This study evaluated the effect of cranial radiation on the pharmacokinetics of irinotecan in plasma and cerebrospinal flui...
  13. Effect of radiation on the penetration of irinotecan in rat cerebrospinal fluid.

    Cancer Chemotherapy and Pharmacology 68(3):721 (2011) PMID 21161529

    Anticancer agents are useful for treating brain tumors, but sub therapeutic concentrations due to decreased blood-brain barrier (BBB) penetration limit their effectiveness. This study evaluated the effect of cranial radiation on the pharmacokinetics of irinotecan in plasma and cerebrospinal flui...
  14. Studies of biaxial mechanical properties and nonlinear finite element modeling of skin.

    Molecular & Cellular Biomechanics 7(2):93 (2010) PMID 20936741

    The objective of this research is to conduct mechanical property studies of skin from two individual but potentially connected aspects. One is to determine the mechanical properties of the skin experimentally by biaxial tests, and the other is to use the finite element method to model the skin p...
  15. Studies of biaxial mechanical properties and nonlinear finite element modeling of skin.

    Molecular & Cellular Biomechanics 7(2):93 (2010) PMID 20936741

    The objective of this research is to conduct mechanical property studies of skin from two individual but potentially connected aspects. One is to determine the mechanical properties of the skin experimentally by biaxial tests, and the other is to use the finite element method to model the skin p...
  16. A chitosan/beta-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer.

    Biomaterials 31(14):4157 (2010) PMID 20185170

    We report here the development of a chitosan/beta-glycerophosphate(Ch/beta-GP) thermo-sensitive gel to deliver ellagic acid (EA) for cancer treatment. The properties of the Ch/beta-GP gels were characterized regarding chemical structure, surface morphology, and viscoelasticity. In vitro EA relea...
  17. Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation.

    International Journal of Radiation Oncology*Bio... 76(5):1537 (2010) PMID 20338480 PMCID PMC2846307

    Ionizing radiation, an important component of glioma therapy, is critically dependent on tumor oxygenation. However, gliomas are notable for areas of necrosis and hypoxia, which foster radioresistance. We hypothesized that pharmacologic manipulation of the typically dysfunctional tumor vasculatu...
  18. Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation.

    International Journal of Radiation Oncology*Bio... 76(5):1537 (2010) PMID 20338480 PMCID PMC2846307

    Ionizing radiation, an important component of glioma therapy, is critically dependent on tumor oxygenation. However, gliomas are notable for areas of necrosis and hypoxia, which foster radioresistance. We hypothesized that pharmacologic manipulation of the typically dysfunctional tumor vasculatu...
  19. IFN-beta restricts tumor growth and sensitizes alveolar rhabdomyosarcoma to ionizing radiation.

    Molecular Cancer Therapeutics 9(3):761 (2010) PMID 20197402

    Ionizing radiation is an important component of multimodal therapy for alveolar rhabdomyosarcoma (ARMS). We sought to evaluate the ability of IFN-beta to enhance the activity of ionizing radiation. Rh-30 and Rh-41 ARMS cells were treated with IFN-beta and ionizing radiation to assess synergistic...
  20. IFN-beta restricts tumor growth and sensitizes alveolar rhabdomyosarcoma to ionizing radiation.

    Molecular Cancer Therapeutics 9(3):761 (2010) PMID 20197402

    Ionizing radiation is an important component of multimodal therapy for alveolar rhabdomyosarcoma (ARMS). We sought to evaluate the ability of IFN-beta to enhance the activity of ionizing radiation. Rh-30 and Rh-41 ARMS cells were treated with IFN-beta and ionizing radiation to assess synergistic...