1. Sustained release chemotherapeutic microspheres provide superior efficacy over systemic therapy and local bolus infusions.

    Pharmaceutical Research 19(7):1052 (2002) PMID 12180539

    The present studies evaluated the ability of injectable, biodegradable microspheres releasing carboplatin, doxorubicin, or 5-fluorouracil to suppress the growth of solid tumors implanted subcutaneously or intramuscularly. Seven to 10 days after implantation of MATB-III cells, rats received syste...