1. Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death.

    Cell 162(2):403 (2015) PMID 26165941

    Small molecules that interfere with microtubule dynamics, such as Taxol and the Vinca alkaloids, are widely used in cell biology research and as clinical anticancer drugs. However, their activity cannot be restricted to specific target cells, which also causes severe side effects in chemotherapy...
  2. Human T-cell leukemia virus type 3 (HTLV-3) and HTLV-4 antisense-transcript-encoded proteins interact and transactivate Jun family-dependent transcription via their atypical bZIP motif.

    Journal of Virology 88(16):8956 (2014) PMID 24872589 PMCID PMC4136272

    Human T-cell leukemia virus types 3 and 4 (HTLV-3 and HTLV-4) are recently isolated retroviruses. We have previously characterized HTLV-3- and HTLV-4-encoded antisense genes, termed APH-3 and APH-4, respectively, which, in contrast to HBZ, the HTLV-1 homologue, do not contain a typical bZIP doma...
  3. Human T-cell leukemia virus type 3 (HTLV-3) and HTLV-4 antisense-transcript-encoded proteins interact and transactivate Jun family-dependent transcription via their atypical bZIP motif.

    Journal of Virology 88(16):8956 (2014) PMID 24872589 PMCID PMC4136272

    Human T-cell leukemia virus types 3 and 4 (HTLV-3 and HTLV-4) are recently isolated retroviruses. We have previously characterized HTLV-3- and HTLV-4-encoded antisense genes, termed APH-3 and APH-4, respectively, which, in contrast to HBZ, the HTLV-1 homologue, do not contain a typical bZIP doma...
  4. Human T-cell leukemia virus type 3 (HTLV-3) and HTLV-4 antisense-transcript-encoded proteins interact and transactivate Jun family-dependent transcription via their atypical bZIP motif.

    Journal of Virology 88(16):8956 (2014) PMID 24872589 PMCID PMC4136272

    Human T-cell leukemia virus types 3 and 4 (HTLV-3 and HTLV-4) are recently isolated retroviruses. We have previously characterized HTLV-3- and HTLV-4-encoded antisense genes, termed APH-3 and APH-4, respectively, which, in contrast to HBZ, the HTLV-1 homologue, do not contain a typical bZIP doma...
  5. Human T-cell leukemia virus type 3 (HTLV-3) and HTLV-4 antisense-transcript-encoded proteins interact and transactivate Jun family-dependent transcription via their atypical bZIP motif.

    Journal of Virology 88(16):8956 (2014) PMID 24872589 PMCID PMC4136272

    Human T-cell leukemia virus types 3 and 4 (HTLV-3 and HTLV-4) are recently isolated retroviruses. We have previously characterized HTLV-3- and HTLV-4-encoded antisense genes, termed APH-3 and APH-4, respectively, which, in contrast to HBZ, the HTLV-1 homologue, do not contain a typical bZIP doma...
  6. In vitro differentiation and expansion of human pluripotent stem cell-derived pancreatic progenitors.

    The Review of Diabetic Studies 11(1):19 (2014) PMID 25148365

    Recent progress in understanding stem cell biology has been remarkable, especially in deciphering signals that support differentiation towards tissue-specific lineages. This achievement positions us firmly at the beginning of an era of patient-specific regenerative medicine and human disease mod...
  7. In vitro differentiation and expansion of human pluripotent stem cell-derived pancreatic progenitors.

    The Review of Diabetic Studies 11(1):19 (2014) PMID 25148365 PMCID PMC4295798

    Recent progress in understanding stem cell biology has been remarkable, especially in deciphering signals that support differentiation towards tissue-specific lineages. This achievement positions us firmly at the beginning of an era of patient-specific regenerative medicine and human disease mod...
  8. In vitro differentiation and expansion of human pluripotent stem cell-derived pancreatic progenitors.

    The Review of Diabetic Studies 11(1):19 (2014) PMID 25148365 PMCID PMC4295798

    Recent progress in understanding stem cell biology has been remarkable, especially in deciphering signals that support differentiation towards tissue-specific lineages. This achievement positions us firmly at the beginning of an era of patient-specific regenerative medicine and human disease mod...
  9. HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene.

    Carcinogenesis 34(11):2664 (2013) PMID 23784080

    Telomerase activity in cancer cells is dependent on the transcriptional regulation of the human telomerase reverse transcriptase (hTERT) gene, encoding the catalytic subunit of human telomerase. We have shown previously that HTLV-1 basic leucine zipper (HBZ), a viral regulatory protein encoded b...
  10. Time-resolved emission spectra of 4-dimethylamino-4'-cyano-stilbene and resveratrol in high viscosity solvents and silica matrices.

    Spectrochimica Acta Part A: Molecular and Biomo... 115:111 (2013) PMID 23832219

    Time-resolved emission spectra of 4-dimethylamino-4'-cyano-stilbene (DMACS) and 3,5,4'-trihydroxy-stilbene (resveratrol, RSV) in propylene glycol and in rigid silica xerogel matrix at 23°C were studied. For the polar molecule DMACS in propylene glycol, a 66nm shift of maximum wavelength of emiss...
  11. Time-resolved emission spectra of 4-dimethylamino-4′-cyano-stilbene and resveratrol in high viscosity solvents and silica matrices

    Spectrochimica Acta Part A: Molecular and Biomo... 115:111 (2013) PMID 23832219

    Graphical abstract
  12. HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene.

    Carcinogenesis 34(11):2664 (2013) PMID 23784080

    Telomerase activity in cancer cells is dependent on the transcriptional regulation of the human telomerase reverse transcriptase (hTERT) gene, encoding the catalytic subunit of human telomerase. We have shown previously that HTLV-1 basic leucine zipper (HBZ), a viral regulatory protein encoded b...
  13. Time-resolved emission spectra of 4-dimethylamino-4′-cyano-stilbene and resveratrol in high viscosity solvents and silica matrices

    Spectrochimica Acta Part A: Molecular and Biomo... 115:111 (2013)

    Graphical abstract
  14. Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation.

    Development 140(3):675 (2013) PMID 23293299 PMCID PMC3561793

    Embryonic stem (ES) cells hold great promise with respect to their potential to be differentiated into desired cell types. Of interest are organs derived from the definitive endoderm, such as the pancreas and liver, and animal studies have revealed an essential role for Nodal in development of t...
  15. Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation.

    Development 140(3):675 (2013) PMID 23293299 PMCID PMC3561793

    Embryonic stem (ES) cells hold great promise with respect to their potential to be differentiated into desired cell types. Of interest are organs derived from the definitive endoderm, such as the pancreas and liver, and animal studies have revealed an essential role for Nodal in development of t...
  16. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.

    Nature 491(7426):765 (2012) PMID 23041930

    One goal of regenerative medicine, to use stem cells to replace cells lost by injury or disease, depends on producing an excess of the relevant cell for study or transplantation. To this end, the stepwise differentiation of stem cells into specialized derivatives has been successful for some cel...
  17. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.

    Nature 491(7426):765 (2012) PMID 23041930

    One goal of regenerative medicine, to use stem cells to replace cells lost by injury or disease, depends on producing an excess of the relevant cell for study or transplantation. To this end, the stepwise differentiation of stem cells into specialized derivatives has been successful for some cel...
  18. The new generation of beta-cells: replication, stem cell differentiation, and the role of small molecules.

    The Review of Diabetic Studies 7(2):93 (2010) PMID 21060968 PMCID PMC2989782

    Diabetic patients suffer from the loss of insulin-secreting β-cells, or from an improper working β-cell mass. Due to the increasing prevalence of diabetes across the world, there is a compelling need for a renewable source of cells that could replace pancreatic β-cells. In recent years, several ...
  19. The new generation of beta-cells: replication, stem cell differentiation, and the role of small molecules.

    The Review of Diabetic Studies 7(2):93 (2010) PMID 21060968 PMCID PMC2989782

    Diabetic patients suffer from the loss of insulin-secreting β-cells, or from an improper working β-cell mass. Due to the increasing prevalence of diabetes across the world, there is a compelling need for a renewable source of cells that could replace pancreatic β-cells. In recent years, several ...
  20. How to make β cells?

    Current Opinion in Cell Biology 21(6):727 (2009) PMID 19781928

    Insulin-producing β cells are lost or insufficient in diabetic patients, presenting the medical challenge for new β cells. Currently, there are three strategies that offer promise. One involves the generation of β cells de novo by directing the differentiation of either embryonic stem ...