1. Mast cells in renal inflammation and fibrosis: lessons learnt from animal studies.

    Molecular Immunology 63(1):86 (2015) PMID 24793464

    Mast cells are hematopoietic cells involved in inflammation and immunity and have been recognized also as important effector cells in kidney inflammation. In humans, only a few mast cells reside in kidneys constitutively but in progressive renal diseases their numbers increase substantially repr...
  2. Mast cells in renal inflammation and fibrosis: lessons learnt from animal studies.

    Molecular Immunology 63(1):86 (2015) PMID 24793464

    Mast cells are hematopoietic cells involved in inflammation and immunity and have been recognized also as important effector cells in kidney inflammation. In humans, only a few mast cells reside in kidneys constitutively but in progressive renal diseases their numbers increase substantially repr...
  3. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  4. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  5. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  6. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  7. Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

    Journal of Clinical Investigation 124(9):3945 (2014) PMID 25061875 PMCID PMC4151227

    Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developi...
  8. Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

    Journal of Clinical Investigation 124(9):3945 (2014) PMID 25061875 PMCID PMC4151227

    Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developi...
  9. Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

    Journal of Clinical Investigation 124(9):3945 (2014) PMID 25061875 PMCID PMC4151227

    Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developi...
  10. Role of FcγRIIIA (CD16) in IVIg-mediated anti-inflammatory function.

    Journal of Clinical Immunology 34 Suppl 1:S46 (2014) PMID 24728843

    The mechanism for anti-inflammatory action of intravenous immunoglobulin (IVIg) in the treatment of autoimmune and inflammatory diseases involves IgG Fc receptors (FcγR). Although the inhibitory FcγRIIB plays an important role in IVIg action, FcγRIIIA has recently been identified as another majo...
  11. Role of FcγRIIIA (CD16) in IVIg-mediated anti-inflammatory function.

    Journal of Clinical Immunology 34 Suppl 1:S46 (2014) PMID 24728843

    The mechanism for anti-inflammatory action of intravenous immunoglobulin (IVIg) in the treatment of autoimmune and inflammatory diseases involves IgG Fc receptors (FcγR). Although the inhibitory FcγRIIB plays an important role in IVIg action, FcγRIIIA has recently been identified as another majo...
  12. Regulation of the tyrosine phosphorylation of Phospholipid Scramblase 1 in mast cells that are stimulated through the high-affinity IgE receptor.

    PLoS ONE 9(10):e109800 (2014) PMID 25289695 PMCID PMC4188579

    Engagement of high-affinity immunoglobulin E receptors (FcεRI) activates two signaling pathways in mast cells. The Lyn pathway leads to recruitment of Syk and to calcium mobilization whereas the Fyn pathway leads to phosphatidylinositol 3-kinase recruitment. Mapping the connections between both ...
  13. Regulation of the tyrosine phosphorylation of Phospholipid Scramblase 1 in mast cells that are stimulated through the high-affinity IgE receptor.

    PLoS ONE 9(10):e109800 (2014) PMID 25289695 PMCID PMC4188579

    Engagement of high-affinity immunoglobulin E receptors (FcεRI) activates two signaling pathways in mast cells. The Lyn pathway leads to recruitment of Syk and to calcium mobilization whereas the Fyn pathway leads to phosphatidylinositol 3-kinase recruitment. Mapping the connections between both ...
  14. Deciphering new molecular mechanisms of mast cell activation.

    Frontiers in Immunology 4:100 (2013) PMID 23630529 PMCID PMC3635034

  15. Deciphering new molecular mechanisms of mast cell activation.

    Frontiers in Immunology 4:100 (2013) PMID 23630529 PMCID PMC3635034

  16. The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy.

    Kidney International 82(12):1284 (2012) PMID 22951891

    IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, has significant morbidity and mortality as 20-40% of patients progress to end-stage renal disease within 20 years of onset. In order to gain insight into the molecular mechanisms involved in the progression of IgAN, we...
  17. The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy.

    Kidney International 82(12):1284 (2012) PMID 22951891

    IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, has significant morbidity and mortality as 20-40% of patients progress to end-stage renal disease within 20 years of onset. In order to gain insight into the molecular mechanisms involved in the progression of IgAN, we...
  18. The TRPM4 channel controls monocyte and macrophage, but not neutrophil, function for survival in sepsis.

    Journal of Immunology 189(7):3689 (2012) PMID 22933633

    A favorable outcome following acute bacterial infection depends on the ability of phagocytic cells to be recruited and properly activated within injured tissues. Calcium (Ca(2+)) is a ubiquitous second messenger implicated in the functions of many cells, but the mechanisms involved in the regula...
  19. The TRPM4 channel controls monocyte and macrophage, but not neutrophil, function for survival in sepsis.

    Journal of Immunology 189(7):3689 (2012) PMID 22933633

    A favorable outcome following acute bacterial infection depends on the ability of phagocytic cells to be recruited and properly activated within injured tissues. Calcium (Ca(2+)) is a ubiquitous second messenger implicated in the functions of many cells, but the mechanisms involved in the regula...
  20. Transglutaminase is essential for IgA nephropathy development acting through IgA receptors.

    Journal of Experimental Medicine 209(4):793 (2012) PMID 22451718 PMCID PMC3328362

    IgA nephropathy (IgAN) is a common cause of renal failure worldwide. Treatment is limited because of a complex pathogenesis, including unknown factors favoring IgA1 deposition in the glomerular mesangium. IgA receptor abnormalities are implicated, including circulating IgA-soluble CD89 (sCD89) c...