1. Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62.

    Experimental Parasitology 132(1):97 (2012) PMID 21925176

    ES-62 is an immunomodulatory phosphorylcholine (PC)-containing glycoprotein secreted by the rodent filarial nematode Acanthocheilonema viteae. Previously, the use of knockout mice has revealed the effects of ES-62 on macrophages and dendritic cells to be dependent on TLR4. However, it is possibl...
  2. Receptor usage by theAcanthocheilonema viteae-derived immunomodulator, ES-62

    Experimental Parasitology 132(1):97 (2012)

    Graphical abstract The filarial nematode immunomodulatory molecule, ES-62 requires TLR4 for binding and internalization by macrophages but not B lymphocytes.
  3. Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter.

    American Journal of Respiratory and Critical Ca... 170(3):252 (2004) PMID 15087293

    5-Hydroxytryptamine (5-HT) plays an important role in the remodeling of the pulmonary circulation, notably during exposure to hypoxia. Here, we have been interested in the role of 5-HT and the 5-HT transporter in the proliferation of pulmonary artery fibroblasts derived from pulmonary hypertensi...
  4. A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62.

    Journal of Immunology 171(4):2127 (2003) PMID 12902519

    Understanding modulation of the host immune system by pathogens offers rich therapeutic potential. Parasitic filarial nematodes are often tolerated in human hosts for decades with little evidence of pathology and this appears to reflect parasite-induced suppression of host proinflammatory immune...
  5. The role of G-proteins versus protein tyrosine kinases in the regulation of lymphocyte activation

    Immunology Today 13(12):482 (1992)

    The relative roles of G-proteins and protein tyrosine kinases (PTKs) in the regulation of antigen receptor-mediated signalling in B and T cells is controversial. As they, and the biochemical events they control, are potential targets for intervention in various immune dysfunctions, the reso...