H3K4 acetylation, H3K9 acetylation and H3K27 methylation in breast tumor molecular subtypes.
Epigenomics 8(7):909 (2016)
Here, we investigated how the St Gallen breast molecular subtypes displayed distinct histone H3 profiles.
192 breast tumors divided into five St Gallen molecular subtypes (luminal A, luminal B HER2-, luminal B HER2+, HER2+ and basal-like) were evaluated for their histone H3 modifications on gene...
The JMJD3 Histone Demethylase and the EZH2 Histone Methyltransferase in Prostate Cancer.
OMICS: A Journal of Integrative Biology 20(2):123 (2016)
Genome-wide DNA methylation modified by soy phytoestrogens: role for epigenetic therapeutics in prostate cancer?
OMICS: A Journal of Integrative Biology 19(4):209 (2015)
In prostate cancer, DNA methylation is significantly associated with tumor initiation, progression, and metastasis. Previous studies have suggested that soy phytoestrogens might regulate DNA methylation at individual candidate gene loci and that they play a crucial role as potential therapeutic ...
Prostate cancer: The main risk and protective factors-Epigenetic modifications.
Annales d'Endocrinologie 76(1):25 (2015)
With 13 million new cases worldwide every year, prostate cancer is as a very real public health concern. Prostate cancer is common in over-50s men and the sixth-leading cause of cancer-related death in men worldwide. Like all cancers, prostate cancer is multifactorial - there are non-modifiable ...
The Role of Soy Phytoestrogens on Genetic and Epigenetic Mechanisms of Prostate Cancer.
The enzymes / edited by Paul D. Boyer 37:193 (2015)
Soy phytoestrogens are dietary components with considerable effects on reducing the incidence of prostate cancer. Epidemiological studies demonstrated that occurrence of prostate cancer is relatively low in Asia and Southern Europe, a status associated with consuming of soy isoflavones, such as ...
A bivalent role of TIP60 histone acetyl transferase in human cancer.
Epigenomics 7(8):1351 (2015)
Acetylation is a major modification that is required for gene regulation, genome maintenance and metabolism. A dysfunctional acetylation plays an important role in several diseases, including cancer. A group of enzymes-lysine acetyltransferases are responsible for this modification and act in re...
Epigenetics of prostate cancer: distribution of histone H3K27me3 biomarkers in peri-tumoral tissue.
OMICS: A Journal of Integrative Biology 18(3):207 (2014)
Epigenetic mechanisms of breast cancer: an update of the current knowledge.
Epigenomics 6(6):651 (2014)
Epigenetic alterations are heritable changes in gene expression that occur without causing any change in DNA sequence. They are important key factors for cancer development and prognosis. Breast cancer is induced by the accumulation of altered gene regulation. Besides genetic mutations, epigenet...
Comparative effects of soy phytoestrogens and 17β-estradiol on DNA methylation of a panel of 24 genes in prostate cancer cell lines.
Nutrition and Cancer 66(3):474 (2014)
Major phytoestrogens genistein and daidzein have been reported to have the ability to reverse DNA methylation in cancer cell lines. The mechanism by which genistein and daidzein have an inhibiting action on DNA methylation is not well understood. The aim of this study was to investigate the effe...
Epigenetic modifications in prostate cancer.
Epigenomics 6(4):415 (2014)
Prostate cancer is the most common cancer in men and the second leading cause of cancer deaths in men in France. Apart from the genetic alterations in prostate cancer, epigenetics modifications are involved in the development and progression of this disease. Epigenetic events are the main cause ...
The association between histone 3 lysine 27 trimethylation (H3K27me3) and prostate cancer: relationship with clinicopathological parameters.
BMC Cancer 14:994 (2014)
It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate cancer carcinogenesis is increasingly evident. In this study, the focus will be on his...
Gene panel model predictive of outcome in patients with prostate cancer.
OMICS: A Journal of Integrative Biology 17(8):407 (2013)
In men at high risk for prostate cancer, established clinical and pathological parameters provide only limited prognostic information. Here we analyzed a French cohort of 103 prostate cancer patients and developed a gene panel model predictive of outcome in this group of patients. The model comp...
Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines.
Epigenomics 5(1):51 (2013)
The isoflavones genistein, daidzein and equol (daidzein metabolite) have been reported to interact with epigenetic modifications, specifically hypermethylation of tumor suppressor genes. The objective of this study was to analyze and understand the mechanisms by which phytoestrogens act on chrom...
Genistein and daidzein: different molecular effects on prostate cancer.
Anticancer Research 33(1):39 (2013)
Diet is believed to play an important role in cancer. It has been revealed by epidemiological studies that Asian populations, who consume phytoestrogens in large amounts, have a lower incidence of prostate cancer in comparison with the Western world, where consumption of soy is lower. Genistein ...
Breast cancer: mechanisms involved in action of phytoestrogens and epigenetic changes.
In Vivo 27(1):1 (2013)
In this review, we consider phytoestrogens and different epigenetic modifications in breast cancer. Epigenetic phenomena are mediated by several molecular mechanisms comprising histone modifications, small non-coding or anti-sense RNA and DNA methylation. These different modifications are closel...