1. A Massive Expansion of Effector Genes Underlies Gall-Formation in the Wheat Pest Mayetiola destructor

    Current Biology 25(5):613 (2015) PMID 25660540

    Gall-forming arthropods are highly specialized herbivores that, in combination with their hosts, produce extended phenotypes with unique morphologies [1]. Many are economically important, and others have improved our understanding of ecology and adaptive radiation [2]. However, the mec...
  2. A Massive Expansion of Effector Genes Underlies Gall-Formation in the Wheat Pest Mayetiola destructor.

    Current Biology 25(5):613 (2015) PMID 25660540

    Gall-forming arthropods are highly specialized herbivores that, in combination with their hosts, produce extended phenotypes with unique morphologies [1]. Many are economically important, and others have improved our understanding of ecology and adaptive radiation [2]. However, the mechanisms th...
  3. A Massive Expansion of Effector Genes Underlies Gall-Formation in the Wheat Pest Mayetiola destructor

    Current Biology (2014)

    • The plant galling Mayetiola destructor genome is replete with effector genes • The SSGP-71 effector gene family is the largest known arthropod gene family. ...
  4. The Pax6 genes eyeless and twin of eyeless are required for global patterning of the ocular segment in the Tribolium embryo.

    Developmental Biology 394(2):367 (2014) PMID 25149513

    The transcription factor gene Pax6 is widely considered a master regulator of eye development in bilaterian animals. However, the existence of visual organs that develop without Pax6 input and the considerable pleiotropy of Pax6 outside the visual system dictate further studies into defining anc...
  5. The Pax6 genes eyeless and twin of eyeless are required for global patterning of the ocular segment in the Tribolium embryo.

    Developmental Biology 394(2):367 (2014) PMID 25149513

    The transcription factor gene Pax6 is widely considered a master regulator of eye development in bilaterian animals. However, the existence of visual organs that develop without Pax6 input and the considerable pleiotropy of Pax6 outside the visual system dictate further studies into defining anc...
  6. Common transcriptional mechanisms for visual photoreceptor cell differentiation among Pancrustaceans.

    PLoS Genetics 10(7):e1004484 (2014) PMID 24991928 PMCID PMC4084641

    A hallmark of visual rhabdomeric photoreceptors is the expression of a rhabdomeric opsin and uniquely associated phototransduction molecules, which are incorporated into a specialized expanded apical membrane, the rhabdomere. Given the extensive utilization of rhabdomeric photoreceptors in the e...
  7. Common transcriptional mechanisms for visual photoreceptor cell differentiation among Pancrustaceans.

    PLoS Genetics 10(7):e1004484 (2014) PMID 24991928 PMCID PMC4084641

    A hallmark of visual rhabdomeric photoreceptors is the expression of a rhabdomeric opsin and uniquely associated phototransduction molecules, which are incorporated into a specialized expanded apical membrane, the rhabdomere. Given the extensive utilization of rhabdomeric photoreceptors in the e...
  8. Common transcriptional mechanisms for visual photoreceptor cell differentiation among Pancrustaceans.

    PLoS Genetics 10(7):e1004484 (2014) PMID 24991928 PMCID PMC4084641

    A hallmark of visual rhabdomeric photoreceptors is the expression of a rhabdomeric opsin and uniquely associated phototransduction molecules, which are incorporated into a specialized expanded apical membrane, the rhabdomere. Given the extensive utilization of rhabdomeric photoreceptors in the e...
  9. Physiological intermolecular modification spectroscopy for the prediction of response to anti-tumor necrosis factor therapy in patients with inflammatory bowel diseases.

    Digestive Diseases: clinical reviews 32(4):446 (2014) PMID 24969293

    Anti-tumor necrosis factor (TNF) antibodies have clinical efficiency only in a subgroup of patients with inflammatory bowel diseases (IBD). Prediction of clinical response is a critical clinical problem. Physiological intermolecular modification spectroscopy (PIMS) is a label-free technology per...
  10. Physiological intermolecular modification spectroscopy for the prediction of response to anti-tumor necrosis factor therapy in patients with inflammatory bowel diseases.

    Digestive Diseases: clinical reviews 32(4):446 (2014) PMID 24969293

    Anti-tumor necrosis factor (TNF) antibodies have clinical efficiency only in a subgroup of patients with inflammatory bowel diseases (IBD). Prediction of clinical response is a critical clinical problem. Physiological intermolecular modification spectroscopy (PIMS) is a label-free technology per...
  11. The malabsorption of commonly occurring mono and disaccharides: levels of investigation and differential diagnoses.

    Deutsches Ärzteblatt international 110(46):775 (2013) PMID 24300825 PMCID PMC3855820

    Adverse food reactions (AFR) have has recently attracted increased attention from the media and are now more commonly reported by patients. Its classification, diagnostic evaluation, and treatment are complex and present a considerable challenge in clinical practice. Non-immune-mediated types of...
  12. The malabsorption of commonly occurring mono and disaccharides: levels of investigation and differential diagnoses.

    Deutsches Ärzteblatt international 110(46):775 (2013) PMID 24300825 PMCID PMC3855820

    Adverse food reactions (AFR) have has recently attracted increased attention from the media and are now more commonly reported by patients. Its classification, diagnostic evaluation, and treatment are complex and present a considerable challenge in clinical practice. Non-immune-mediated types of...
  13. Biological clocks and visual systems in cave-adapted animals at the dawn of speleogenomics.

    Integrative and Comparative Biology 53(1):50 (2013) PMID 23720528

    Cave-adapted animals are characterized by extreme reduction or complete absence of eyes, reflecting their lack of exposure to daylight. Given the overall constancy of abiotic variables in the cave environment, one would also expect the relaxation and eventual loss of circadian rhythms, and with ...
  14. Biological clocks and visual systems in cave-adapted animals at the dawn of speleogenomics.

    Integrative and Comparative Biology 53(1):50 (2013) PMID 23720528

    Cave-adapted animals are characterized by extreme reduction or complete absence of eyes, reflecting their lack of exposure to daylight. Given the overall constancy of abiotic variables in the cave environment, one would also expect the relaxation and eventual loss of circadian rhythms, and with ...
  15. Inflammatory tinea pedis with bacterial superinfection effectively treated with isoconazole nitrate and diflucortolone valerate combination therapy.

    Mycoses 56 Suppl 1:23 (2013) PMID 23574021

    Undetected tinea pedis in a patient with diabetes can lead to serious bacterial infections with potentially serious consequences, such as foot amputations. Here we report on a 60-year-old patient with diabetes presenting with pain, severe pruritus, and malodour in the foot's interdigital area, a...
  16. Inflammatory tinea pedis with bacterial superinfection effectively treated with isoconazole nitrate and diflucortolone valerate combination therapy.

    Mycoses 56 Suppl 1:23 (2013) PMID 23574021

    Undetected tinea pedis in a patient with diabetes can lead to serious bacterial infections with potentially serious consequences, such as foot amputations. Here we report on a 60-year-old patient with diabetes presenting with pain, severe pruritus, and malodour in the foot's interdigital area, a...
  17. Over-the-scope clip application yields a high rate of closure in gastrointestinal perforations and may reduce emergency surgery.

    Journal of Gastrointestinal Surgery 16(11):2132 (2012) PMID 22903364

    Perforation of the gastrointestinal tract may cause various complications and may require emergency surgery, even in patients with significant comorbidities. Seventeen consecutive patients with indication for surgery due to a visible gastrointestinal perforation were treated with OTSC applicatio...
  18. Dramatic expansion and developmental expression diversification of the methuselah gene family during recent Drosophila evolution.

    Journal of Experimental Zoology, Part B: Molecu... 318(5):368 (2012) PMID 22711569

    Functional studies of the methuselah/methuselah-like (mth/mthl) gene family have focused on the founding member mth, but little is known regarding the developmental functions of this receptor or any of its paralogs. We undertook a comprehensive analysis of developmental expression and sequence d...
  19. Dramatic expansion and developmental expression diversification of the methuselah gene family during recent Drosophila evolution.

    Journal of Experimental Zoology, Part B: Molecu... 318(5):368 (2012) PMID 22711569

    Functional studies of the methuselah/methuselah-like (mth/mthl) gene family have focused on the founding member mth, but little is known regarding the developmental functions of this receptor or any of its paralogs. We undertook a comprehensive analysis of developmental expression and sequence d...
  20. Parallel duplication and partial subfunctionalization of β-catenin/armadillo during insect evolution.

    Molecular Biology and Evolution 29(2):647 (2012) PMID 21890476 PMCID PMC3283115

    β-Catenin is a multifunctional scaffolding protein with roles in Wnt signaling, cell adhesion, and centrosome separation. Here, we report on independent duplications of the insect β-Catenin ortholog armadillo (arm) in the red flour beetle Tribolium castaneum and the pea aphid Acyrthosiphon pisum...