1. Cell therapy for immunosuppression after kidney transplantation.

    Deutsche Zeitschrift für Chirurgie 400(5):541 (2015) PMID 26077202

    To give an overview over cell therapeutic approaches to immunosuppression in clinical kidney transplantation. A focus is on myeloid suppressor cell therapy by mitomycin C-induced cells (MICs). Literature review with an emphasis on already existing therapies. Several cell therapeutic approaches t...
  2. Tailoring of alerts substantially reduces the alert burden in computerized clinical decision support for drugs that should be avoided in patients with renal disease.

    Journal of the American Medical Informatics Ass... 22(4):881 (2015) PMID 25911673

    Electronic alerts are often ignored by physicians, which is partly due to the large number of unspecific alerts generated by decision support systems. The aim of the present study was to analyze critical drug prescriptions in a university-based nephrology clinic and to evaluate the effect of dif...
  3. Evolution of allograft fibrosis and function in kidney transplant recipients: a retrospective analysis of stable patients under CNI and mTORi.

    Transplant International 28(5):553 (2015) PMID 25630217

    Histological evaluations of renal allograft biopsies are essential for diagnosis, but still show a low predictive value for long-term allograft function. One limitation relies on the fact that the analysis is usually based on a single biopsy sample, and therefore, no dynamic changes are consider...
  4. Peritoneal ultrafiltration in end-stage chronic heart failure.

    Clinical Kidney Journal 8(2):219 (2015) PMID 25815181 PMCID PMC4370307

    Cardiorenal syndrome type 2 (CRS-2) is common in end-stage chronic heart failure (CHF). Peritoneal ultrafiltration (pUF) may entail clinical functional improvement and a reduction in hospitalizations. Thirty-nine consecutive end-stage CHF patients with stable CRS-2 were initiated on ambulatory p...
  5. High interpatient variability in response to mycophenolic acid maintenance therapy in patients with ANCA-associated vasculitis.

    Nephrology Dialysis Transplantation 30 Suppl 1:i138 (2015) PMID 25805745

    Mycophenolic acid (MPA) is used in the maintenance therapy of antineutrophil cytoplasm antibody-associated systemic vasculitis (AASV). MPA exerts its immunosuppression by inhibiting inosine 5'-monophosphate dehydrogenase (IMPDH), depleting activated lymphocytes of guanine nucleotides and retardi...
  6. Psychosocial and physical outcome following kidney donation-a retrospective analysis.

    Transplant International 28(4):416 (2015) PMID 25557158

    Living renal donation is of benefit to the allograft recipient. Careful analysis of the donor outcome is necessary with respect to the medical condition, socioeconomic status, and health-related quality of life. All living kidney donors of the Transplant Center at Heidelberg were included. Renal...
  7. Psychosocial and physical outcome following kidney donation-a retrospective analysis.

    Transplant International 28(4):416 (2015) PMID 25557158

    Living renal donation is of benefit to the allograft recipient. Careful analysis of the donor outcome is necessary with respect to the medical condition, socioeconomic status, and health-related quality of life. All living kidney donors of the Transplant Center at Heidelberg were included. Renal...
  8. Increased peritoneal damage in glyoxalase 1 knock-down mice treated with peritoneal dialysis.

    Nephrology Dialysis Transplantation 30(3):401 (2015) PMID 25387474

    Peritoneal dialysis (PD) is limited by peritoneal fibrosis and ultrafiltration failure. This is in part caused by the high concentration of glucose degradation products (GDPs) present in PD fluids (PDF) as a consequence of heat sterilization. Existing research in long-term PD has mainly dealt wi...
  9. Increased peritoneal damage in glyoxalase 1 knock-down mice treated with peritoneal dialysis.

    Nephrology Dialysis Transplantation 30(3):401 (2015) PMID 25387474

    Peritoneal dialysis (PD) is limited by peritoneal fibrosis and ultrafiltration failure. This is in part caused by the high concentration of glucose degradation products (GDPs) present in PD fluids (PDF) as a consequence of heat sterilization. Existing research in long-term PD has mainly dealt wi...
  10. Three-Year Outcomes Following 1420 ABO-Incompatible Living-Donor Kidney Transplants Performed After ABO Antibody Reduction: Results From 101 Centers.

    Transplantation 99(2):400 (2015) PMID 25050471

    Reports from experienced centers suggest that recipients of an ABO-incompatible living-donor kidney transplant after reduction of ABO antibodies experience no penalty in graft and patient survival versus ABO-compatible transplants, but confirmation that these results can be widely replicated is ...
  11. Three-year outcomes following 1420 ABO-incompatible living-donor kidney transplants performed after ABO antibody reduction: results from 101 centers.

    Transplantation 99(2):400 (2015) PMID 25050471

    Reports from experienced centers suggest that recipients of an ABO-incompatible living-donor kidney transplant after reduction of ABO antibodies experience no penalty in graft and patient survival versus ABO-compatible transplants, but confirmation that these results can be widely replicated is ...
  12. Interdisciplinary counseling service for renal malignancies: a patient-centered approach to raise guideline adherence.

    Urologic Oncology: Seminars and Original Invest... 33(1):23.e1 (2015) PMID 25465195

    Tumor boards have become an integral part of high-quality cancer care, but in general, patients are not directly involved. To overcome this weakness, we established an interdisciplinary counseling service for renal malignancies where 4 specialists talked to the patient at once. We evaluated this...
  13. Interdisciplinary counseling service for renal malignancies: A patient-centered approach to raise guideline adherence.

    Urologic Oncology: Seminars and Original Invest... 33(1):23.e1 (2015) PMID 25465195

    Tumor boards have become an integral part of high-quality cancer care, but in general, patients are not directly involved. To overcome this weakness, we established an interdisciplinary counseling service for renal malignancies where 4 specialists talked to the patient at once. We evaluated this...
  14. Interdisciplinary counseling service for renal malignancies: A patient-centered approach to raise guideline adherence

    Urologic Oncology: Seminars and Original Invest... 33(1) (2015) PMID 25465195

    Objectives Tumor boards have become an integral part of high quality cancer care, but in general patients are not directly involved. To overcome this weakness we established an interdisciplinary counseling service for renal malignancies where four specialists talked to the pa...
  15. Effect of benfotiamine in podocyte damage induced by peritoneal dialysis fluid.

    Frontiers in medicine 2:10 (2015) PMID 25806370 PMCID PMC4354337

    In peritoneal dialysis (PD), residual renal function (RRF) fundamentally contributes to improved quality of life and patient survival. High glucose and advanced glycation end-products (AGE) contribute locally to peritoneal and systemically to renal damage. Integrity of podocyte structure and fun...
  16. Association of low serum TGF-β level in hantavirus infected patients with severe disease.

    BMC Immunology 16(1):19 (2015) PMID 25888018 PMCID PMC4399110

    Hantaviruses are emerging zoonotic pathogens which cause hemorrhagic fever with renal syndrome, an immune-mediated pathogenesis is discussed. The aim of the present study was to investigate the role of TGF-β expression in acute hantavirus infection. We retrospectively studied 77 patients hospita...
  17. The impact of type 2 diabetes on the outcome of localized renal cell carcinoma.

    World Journal of Urology 32(6):1537 (2014) PMID 24370691

    To evaluate the influence of type 2 diabetes on cancer-specific outcome in patients undergoing surgery for localized renal cell carcinoma (RCC). A total of 1,140 patients with localized RCC undergoing radical or partial nephrectomy were enrolled into this retrospective case-control study. Primar...
  18. The impact of type 2 diabetes on the outcome of localized renal cell carcinoma.

    World Journal of Urology 32(6):1537 (2014) PMID 24370691

    To evaluate the influence of type 2 diabetes on cancer-specific outcome in patients undergoing surgery for localized renal cell carcinoma (RCC). A total of 1,140 patients with localized RCC undergoing radical or partial nephrectomy were enrolled into this retrospective case-control study. Primar...
  19. The impact of type 2 diabetes on the outcome of localized renal cell carcinoma.

    World Journal of Urology 32(6):1537 (2014) PMID 24370691

    To evaluate the influence of type 2 diabetes on cancer-specific outcome in patients undergoing surgery for localized renal cell carcinoma (RCC). A total of 1,140 patients with localized RCC undergoing radical or partial nephrectomy were enrolled into this retrospective case-control study. Primar...
  20. Efficacy and safety of conversion from cyclosporine to everolimus in living-donor kidney transplant recipients: an analysis from the ZEUS study.

    Transplant International 27(11):1192 (2014) PMID 25070687

    Conversion of living-donor kidney transplant patients from calcineurin inhibitor therapy to an mTOR inhibitor is poorly documented. In the prospective, multicentre ZEUS study, 300 kidney transplant recipients without prior rejection (Banff grade >1) and serum creatinine ≤265 μmol/l were randomiz...