1. High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet.

    Molecular & Cellular Proteomics 14(6):1489 (2015) PMID 25795660 PMCID PMC4458715

    The availability of acyl-Coenzyme A (acyl-CoA) thioester compounds affects numerous cellular functions including autophagy, lipid oxidation and synthesis, and post-translational modifications. Consequently, the acyl-CoA level changes tend to be associated with other metabolic alterations that re...
  2. Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal

    Cell 160(5):842 (2015)

    Low energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved energy sensor AMP-activated protein kinase (AMPK) and its corresponding phosphatase calcineurin modulate longevity via the CREB re...
  3. Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal.

    Cell 160(5):842 (2015) PMID 25723162 PMCID PMC4392909

    Low energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved energy sensor AMP-activated protein kinase (AMPK) and its corresponding phosphatase calcineurin modulate longevity via the CREB regulated tr...
  4. Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal.

    Cell 160(5):842 (2015) PMID 25723162

    Low energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved energy sensor AMP-activated protein kinase (AMPK) and its corresponding phosphatase calcineurin modulate longevity via the CREB regulated tr...
  5. Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Environmental Health Perspectives 122(12):1271 (2014) PMID 25127496

    Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP prod...
    PDF not found
  6. Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Environmental Health Perspectives 122(12):1271 (2014) PMID 25127496 PMCID PMC4256704

    Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP prod...
  7. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.

    Journal of Lipid Research 55(12):2458 (2014) PMID 25114170 PMCID PMC4242439

    Acyl-CoA thioesterase (Acot)2 localizes to the mitochondrial matrix and hydrolyses long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxi-dative tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is unknown. Using a model of ad...
  8. Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Environmental Health Perspectives 122(12):1271 (2014) PMID 25127496 PMCID PMC4256704

    Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP prod...
  9. Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Environmental Health Perspectives 122(12):1271 (2014) PMID 25127496 PMCID PMC4256704

    Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP prod...
  10. Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Environmental Health Perspectives 122(12):1271 (2014) PMID 25127496 PMCID PMC4256704

    Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP prod...
  11. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.

    Journal of Lipid Research 55(12):2458 (2014) PMID 25114170 PMCID PMC4242439

    Acyl-CoA thioesterase (Acot)2 localizes to the mitochondrial matrix and hydrolyses long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxi-dative tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is unknown. Using a model of ad...
  12. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.

    Journal of Lipid Research 55(12):2458 (2014) PMID 25114170 PMCID PMC4242439

    Acyl-CoA thioesterase (Acot)2 localizes to the mitochondrial matrix and hydrolyses long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxi-dative tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is unknown. Using a model of ad...
  13. Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Environmental Health Perspectives 122(12):1271 (2014) PMID 25127496

    Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP prod...
    PDF not found
  14. Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Environmental Health Perspectives 122(12):1271 (2014) PMID 25127496 PMCID PMC4256704

    Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP prod...
  15. Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Environmental Health Perspectives 122(12):1271 (2014) PMID 25127496 PMCID PMC4256704

    Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP prod...
  16. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.

    Journal of Lipid Research 55(12):2458 (2014) PMID 25114170 PMCID PMC4242439

    Acyl-CoA thioesterase (Acot)2 localizes to the mitochondrial matrix and hydrolyses long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxi-dative tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is unknown. Using a model of ad...
  17. SnapShot: Mammalian Sirtuins.

    Cell 159(4):956 (2014) PMID 25417168

    The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-bind...
  18. SnapShot: Mammalian Sirtuins.

    Cell 159(4):956 (2014) PMID 25417168 PMCID PMC4337867

    The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-bind...
  19. SnapShot: Mammalian Sirtuins.

    Cell 159(4):956 (2014) PMID 25417168

    The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-bind...
  20. SnapShot: Mammalian Sirtuins.

    Cell 159(4):956 (2014) PMID 25417168

    The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-bind...