1. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364 PMCID PMC4344913

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  2. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364 PMCID PMC4344913

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  3. A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate

    Cell 160(5):1013 (2015)

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases ...
  4. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  5. TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.

    Cell 150(3):481 (2012) PMID 22863003 PMCID PMC3516183

    Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal bodies, and telomerase is thought to be recruited to telomeres through interactions with telomere-binding proteins. Here, we show that the OB-fold domain of the telomere-binding protein TPP1 recruits te...
  6. TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

    Cell 150(3):481 (2012)

    Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal bodies, and telomerase is thought to be recruited to telomeres through interactions with telomere-binding proteins. Here, we show that the OB-fold domain of the telomere-binding protein TPP1 r...
  7. Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling.

    Nature Medicine 18(1):111 (2012) PMID 22138751 PMCID PMC3272332

    Mechanisms of epithelial cell renewal remain poorly understood in the mammalian kidney, particularly in the glomerulus, a site of cellular damage in chronic kidney disease. Within the glomerulus, podocytes--differentiated epithelial cells crucial for filtration--are thought to lack substantial c...
  8. Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling.

    Nature Medicine 18(1):111 (2012) PMID 22138751 PMCID PMC3272332

    Mechanisms of epithelial cell renewal remain poorly understood in the mammalian kidney, particularly in the glomerulus, a site of cellular damage in chronic kidney disease. Within the glomerulus, podocytes--differentiated epithelial cells crucial for filtration--are thought to lack substantial c...
  9. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.

    Nature 474(7351):399 (2011) PMID 21602826 PMCID PMC3155806

    The differentiation of patient-derived induced pluripotent stem cells (iPSCs) to committed fates such as neurons, muscle and liver is a powerful approach for understanding key parameters of human development and disease. Whether undifferentiated iPSCs themselves can be used to probe disease mech...
  10. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.

    Nature 474(7351):399 (2011) PMID 21602826 PMCID PMC3155806

    The differentiation of patient-derived induced pluripotent stem cells (iPSCs) to committed fates such as neurons, muscle and liver is a powerful approach for understanding key parameters of human development and disease. Whether undifferentiated iPSCs themselves can be used to probe disease mech...
  11. TRAPping telomerase within the intestinal stem cell niche.

    EMBO Journal 30(6):986 (2011) PMID 21407250 PMCID PMC3061044

  12. TRAPping telomerase within the intestinal stem cell niche.

    EMBO Journal 30(6):986 (2011) PMID 21407250 PMCID PMC3061044