1. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

    Nature Communications 6:6217 (2015) PMID 25692415 PMCID PMC4346637

    B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influ...
  2. Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: modulatory role of regulatory B cells.

    European Journal of Immunology 44(9):2692 (2014) PMID 24945741 PMCID PMC4209796

    Patients deficient in the cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASp) are predisposed to varied autoimmunity, suggesting it has an important controlling role in participating cells. IL-10-producing regulatory B (Breg) cells are emerging as important mediators of immunosuppress...
  3. Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: modulatory role of regulatory B cells.

    European Journal of Immunology 44(9):2692 (2014) PMID 24945741 PMCID PMC4209796

    Patients deficient in the cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASp) are predisposed to varied autoimmunity, suggesting it has an important controlling role in participating cells. IL-10-producing regulatory B (Breg) cells are emerging as important mediators of immunosuppress...
  4. Genetic variation in schlafen genes in a patient with a recapitulation of the murine Elektra phenotype.

    Journal of Allergy and Clinical Immunology 133(5):1462 (2014) PMID 24373355

  5. Genetic variation in schlafen genes in a patient with a recapitulation of the murine Elektra phenotype

    Journal of Allergy and Clinical Immunology 133(5):1462 (2014)

  6. A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency

    Journal of Allergy and Clinical Immunology 133(4):1222 (2014)

  7. A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency.

    Journal of Allergy and Clinical Immunology 133(4):1222 (2014) PMID 24406071

  8. A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency.

    Journal of Allergy and Clinical Immunology 133(4):1222 (2014) PMID 24406071

  9. [Primary and secondary immunodeficiencies].

    Therapeutische Umschau 71(1):31 (2014) PMID 24394207

    Primary Immunodeficiencies (PID) are rare, genetically determined diseases that cause dysfunctional immunity, clinically presenting as susceptibility to infection but also as autoimmunity due to deficient immune tolerance. More than 180 PID have been described to date. To diagnose a PID, seconda...
  10. Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes.

    PLoS Pathogens 9(10):e1003650 (2013) PMID 24204252 PMCID PMC3812017

    Infection with viruses carrying cross-reactive antigens is associated with break of immunological tolerance and induction of autoimmune disease. Dendritic cells play an important role in this process. However, it remains unclear why autoimmune-tolerance is broken during virus infection, but usua...
  11. A common SNP impairs B cell activating factor receptor's multimerization, contributing to common variable immunodeficiency

    Journal of Allergy and Clinical Immunology (2013)

  12. Adult-onset manifestation of idiopathic T-cell lymphopenia due to a heterozygous RAG1 mutation.

    Journal of Allergy and Clinical Immunology 131(5):1421 (2013) PMID 23122631 PMCID PMC3725988

  13. Adult-onset manifestation of idiopathic T-cell lymphopenia due to a heterozygousRAG1mutation

    Journal of Allergy and Clinical Immunology 131(5):1421 (2013)

  14. Genetic variation inschlafengenes in a patient with a recapitulation of the murine‘Elektra’phenotype

    Journal of Allergy and Clinical Immunology (2013)

  15. Major histocompatibility complex class II deficiency in Kuwait: clinical manifestations, immunological findings and molecular profile.

    Journal of Clinical Immunology 33(3):513 (2013) PMID 23143406

    Major Histocompatibility Complex (MHC) class II deficiency is a combined primary immunodeficiency disease that leads to overwhelming and recurrent infections. It was found to account for 19 % of combined immune deficiency cases in the National Primary Immunodeficiency Disorders Registry in Kuwai...
  16. Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment

    Journal of Allergy and Clinical Immunology 131(4):1136 (2013)

    Background Mutations in Janus kinase 3 (JAK3) are a cause of severe combined immunodeficiency, but hypomorphic JAK3 defects can result in a milder clinical phenotype, with residual development and function of autologous T cells. Maternal T-cell engraftment is a common finding...
  17. Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment.

    Journal of Allergy and Clinical Immunology 131(4):1136 (2013) PMID 23384681

    Mutations in Janus kinase 3 (JAK3) are a cause of severe combined immunodeficiency, but hypomorphic JAK3 defects can result in a milder clinical phenotype, with residual development and function of autologous T cells. Maternal T-cell engraftment is a common finding in infants with severe combine...
  18. Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency.

    Journal of Allergy and Clinical Immunology 131(3):815 (2013) PMID 23141740 PMCID PMC3757164

    Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency caused by absence of Wiskott-Aldrich syndrome protein (WASP) expression, resulting in defective function of many immune cell lineages and susceptibility to severe bacterial, viral, and fungal infections. Despite a signifi...
  19. Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency

    Journal of Allergy and Clinical Immunology 131(3):815 (2013)

    Background Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency caused by absence of Wiskott-Aldrich syndrome protein (WASP) expression, resulting in defective function of many immune cell lineages and susceptibility to severe bacterial, viral, and funga...
  20. Involvement of Toso in activation of monocytes, macrophages, and granulocytes.

    PNAS 110(7):2593 (2013) PMID 23359703 PMCID PMC3574925

    Rapid activation of immune responses is necessary for antibacterial defense, but excessive immune activation can result in life-threatening septic shock. Understanding how these processes are balanced may provide novel therapeutic potential in treating inflammatory disease. Fc receptors are cruc...