1. High hemoglobin A1c variability is associated with early risk of microalbuminuria in children with T1D.

    Pediatric Diabetes 17(6):398 (2016) PMID 26377593

    To test the hypothesis that HbA1c variability, as measured by standard deviation (SD), is associated with increased risk for incident microalbuminuria and persistent microalbuminuria in pediatric type 1 diabetes (T1D). A retrospective analysis using data from electronic health records was perfor...
  2. New approaches to hyperkalemia in patients with indications for renin angiotensin aldosterone inhibitors: Considerations for trial design and regulatory approval.

    International Journal of Cardiology 216:46 (2016) PMID 27140336

    Hyperkalemia is a common clinical problem, especially in patients with chronic kidney disease, diabetes mellitus, or heart failure. Treatment with renin angiotensin aldosterone system inhibitors exacerbates the risk of hyperkalemia in these patients. Concern about hyperkalemia can result in the ...
  3. Prevalence and Prognosis of Hyperkalemia in Patients with Acute Myocardial Infarction.

    The American Journal of Medicine 129(8):858 (2016) PMID 27060233

    Hyperkalemia is common and potentially dangerous in hospitalized patients; its contemporary prevalence and prognostic importance after acute myocardial infarction are not well described. In 38,689 consecutive patients with acute myocardial infarction from the Cerner Health Facts database, we eva...
  4. Predicting Adverse Outcomes After Myocardial Infarction Among Patients With Diabetes Mellitus.

    Circulation: Cardiovascular Quality and Outcomes 9(4):372 (2016) PMID 27220369

    Although patients with diabetes mellitus experience high rates of adverse events after acute myocardial infarction (AMI), including death and recurrent ischemia, some diabetic patients are likely at low risk, whereas others are at high risk. We sought to develop prediction models to stratify ris...
  5. Evaluating the Quality of Comprehensive Cardiometabolic Care for Patients With Type 2 Diabetes in the U.S.: The Diabetes Collaborative Registry.

    Diabetes Care 39(7):e99 (2016) PMID 27222504

  6. Revascularization Trends in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Presenting With Non-ST Elevation Myocardial Infarction: Insights From the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry-Get with the Guidelines (NCDR ACTION Registry-GWTG).

    Circulation: Cardiovascular Quality and Outcomes 9(3):197 (2016) PMID 27166210

    Current guidelines recommend surgical revascularization (coronary artery bypass graft [CABG]) over percutaneous coronary intervention (PCI) in patients with diabetes mellitus and multivessel coronary artery disease. Few data are available describing revascularization patterns among these patient...
  7. Pharmacodynamics and pharmacokinetics of sodium zirconium cyclosilicate [ZS-9] in the treatment of hyperkalemia.

    Expert Opinion on Drug Metabolism and Toxicology 12(5):567 (2016) PMID 26998854

    Hyperkalemia is a common electrolyte disorder that arises from dysfunctional homeostatic mechanisms or as a consequence of decreased renal function. Sodium zirconium cyclosilicate (ZS-9) is a potential new therapy for hyperkalemia in both acute and chronic settings. Here we discuss mechanisms of...
  8. Predicting the Benefit of Statins in Patients With Diabetes Mellitus: A Case of Perfect Being the Enemy of Good?

    Circulation: Cardiovascular Quality and Outcomes 9(3):191 (2016) PMID 27166211

  9. Potential New Agents for the Management of Hyperkalemia.

    American Journal of Cardiovascular Drugs 16(1):19 (2016) PMID 26156040

    Hyperkalemia is a common electrolyte disturbance with multiple potential etiologies. It is usually observed in the setting of reduced renal function. Mild to moderate hyperkalemia is usually asymptomatic, but is associated with poor prognosis. When severe, hyperkalemia may cause serious acute ca...
  10. Long-term excess risk of heart failure in people with type 1 diabetes: a prospective case-control study.

    The lancet. Diabetes & endocrinology 3(11):876 (2015) PMID 26388415

    Diabetes is an established risk factor for heart failure, but because nearly all heart failure occurs in older individuals, the excess risk and risk factors for heart failure in individuals with type 1 diabetes are not known. We aimed to determine the excess risk of heart failure in individuals ...
  11. Excess Mortality among Persons with Type 2 Diabetes.

    New England Journal of Medicine 373(18):1720 (2015) PMID 26510021

    The excess risks of death from any cause and death from cardiovascular causes among persons with type 2 diabetes and various levels of glycemic control and renal complications are unknown. In this registry-based study, we assessed these risks according to glycemic control and renal complications...
  12. Maintenance of serum potassium with sodium zirconium cyclosilicate (ZS-9) in heart failure patients: results from a phase 3 randomized, double-blind, placebo-controlled trial.

    European Journal of Heart Failure 17(10):1050 (2015) PMID 26011677

    Hyperkalaemia in heart failure patients limits use of cardioprotective renin-angiotensin-aldosterone system inhibitors (RAASi). Sodium zirconium cyclosilicate (ZS-9) is a selective potassium ion trap, whose mechanism of action may allow for potassium binding in the upper gastrointestinal tract a...
  13. Glucose-Lowering Medications and Angina Burden in Patients with Stable Coronary Disease: results from the Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina (TERISA) Trial.

    American Heart Journal 170(4):753 (2015) PMID 26386799

    Different classes of glucose-lowering medications have been associated with varying risks of myocardial infarction and cardiovascular death, but their effect on angina is unknown. Therefore, we sought to determine the association of different glucose-lowering medication classes with angina frequ...
  14. Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association.

    Diabetes Care 38(9):1777 (2015) PMID 26246459 PMCID PMC4876675

    Cardiovascular disease risk factor control as primary prevention in patients with type 2 diabetes mellitus has changed substantially in the past few years. The purpose of this scientific statement is to review the current literature and key clinical trials pertaining to blood pressure and blood ...
  15. Glucose management in critically ill adults and children.

    The lancet. Diabetes & endocrinology 3(9):723 (2015) PMID 26071884

    Blood glucose management in people with acute myocardial infarction and critical illness has always attracted controversy. Compared with the era before 2001 when no attention was given to blood glucose management, DIGAMI-1 in 1995 and the first Leuven study in 2001 showed improved outcomes with ...
  16. Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association.

    Circulation 132(8):691 (2015) PMID 26246173

    Cardiovascular disease risk factor control as primary prevention in patients with type 2 diabetes mellitus has changed substantially in the past few years. The purpose of this scientific statement is to review the current literature and key clinical trials pertaining to blood pressure and blood ...
  17. Use of an Intravascular Fluorescent Continuous Glucose Sensor in ICU Patients.

    Journal of diabetes science and technology (Onl... 9(4):762 (2015) PMID 25972280 PMCID PMC4525661

    Hyperglycemia and hypoglycemia are associated with adverse clinical outcomes in intensive care patients. In product development studies at 4 ICUs, the safety and performance of an intravascular continuous glucose monitoring (IV-CGM) system was evaluated in 70 postsurgical patients. The GluCath S...
  18. Hospital variability in use of anticoagulant strategies during acute myocardial infarction treated with an early invasive strategy.

    Journal of the American Heart Association Cardi... 4(6):e002009 (2015) PMID 26077589 PMCID PMC4599539

    During a myocardial infarction, no single best approach of systemic anticoagulation is recommended, likely due to a lack of comparative effectiveness studies and trade-offs between treatments. We investigated the patterns of use and site-level variability in anticoagulant strategies (unfractiona...
  19. Association between diabetes mellitus and angina after acute myocardial infarction: analysis of the TRIUMPH prospective cohort study.

    European Journal of Preventive Cardiology 22(6):779 (2015) PMID 24740679 PMCID PMC4199926

    While patients with diabetes mellitus (DM) have more extensive coronary disease and worse survival after acute myocardial infarction (AMI) than patients without DM, data on whether they experience more angina are conflicting. We examined angina prevalence over the year following AMI among 3367 p...
  20. Recognition of incident diabetes mellitus during an acute myocardial infarction.

    Circulation: Cardiovascular Quality and Outcomes 8(3):260 (2015) PMID 25901045 PMCID PMC4439264

    Diabetes mellitus (DM) is common in patients hospitalized with an acute myocardial infarction (AMI), representing in some cases the first opportunity to recognize and treat DM. We report the incidence of new DM and its recognition among patients with AMI. Patients in a 24-site US AMI registry (2...