1. (13) C magnetic resonance spectroscopic imaging of hyperpolarized [1-(13) C, U-(2) H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo.

    Magnetic Resonance in Medicine 73(5):1733 (2015) PMID 24800934

    Aldehyde dehydrogenase (ALDH2) is an emerging drug target for the treatment of heart disease, cocaine and alcohol dependence, and conditions caused by genetic polymorphisms in ALDH2. Noninvasive measurement of ALDH2 activity in vivo could inform the development of these drugs and accelerate thei...
  2. Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy.

    Magnetic Resonance in Medicine 73(4):1401 (2015) PMID 24733406

    To assess the potential of a gene reporter system, based on a urea transporter (UTB) and hyperpolarized [(13) C]urea. Mice were implanted subcutaneously with either unmodified control cells or otherwise identical cells expressing UTB. After injection of hyperpolarized [(13) C]urea, a spin echo s...
  3. Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy.

    JNCI Journal of the National Cancer Institute 106(5) (2014) PMID 24777112 PMCID PMC4112924

    Many prognostic biomarkers have been proposed recently. However, there is a lack of therapeutic strategies exploiting novel prognostic biomarkers. We aimed to propose therapeutic options in patients with overexpression of TRIM44, a recently identified prognostic gene. Genomic and transcriptomic ...
  4. Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy.

    JNCI Journal of the National Cancer Institute 106(5) (2014) PMID 24777112 PMCID PMC4112924

    Many prognostic biomarkers have been proposed recently. However, there is a lack of therapeutic strategies exploiting novel prognostic biomarkers. We aimed to propose therapeutic options in patients with overexpression of TRIM44, a recently identified prognostic gene. Genomic and transcriptomic ...
  5. Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy.

    JNCI Journal of the National Cancer Institute 106(5) (2014) PMID 24777112 PMCID PMC4112924

    Many prognostic biomarkers have been proposed recently. However, there is a lack of therapeutic strategies exploiting novel prognostic biomarkers. We aimed to propose therapeutic options in patients with overexpression of TRIM44, a recently identified prognostic gene. Genomic and transcriptomic ...
  6. In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding.

    PMID 24486720

    Hyperpolarized metabolic imaging is a growing field that has provided a new tool for analyzing metabolism, particularly in cancer. Given the short life times of the hyperpolarized signal, fast and effective spectroscopic imaging methods compatible with dynamic metabolic characterizations are nec...
  7. In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding.

    PMID 24486720

    Hyperpolarized metabolic imaging is a growing field that has provided a new tool for analyzing metabolism, particularly in cancer. Given the short life times of the hyperpolarized signal, fast and effective spectroscopic imaging methods compatible with dynamic metabolic characterizations are nec...
  8. In vivosingle-shot13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

    Journal of Magnetic Resonance 240:8 (2014)

    Graphical abstract
  9. Dual-modality gene reporter for in vivo imaging.

    PNAS 111(1):415 (2014) PMID 24347640 PMCID PMC3890795

    The ability to track cells and their patterns of gene expression in living organisms can increase our understanding of tissue development and disease. Gene reporters for bioluminescence, fluorescence, radionuclide, and magnetic resonance imaging (MRI) have been described but these suffer various...
  10. Dual-modality gene reporter for in vivo imaging.

    PNAS 111(1):415 (2014) PMID 24347640 PMCID PMC3890795

    The ability to track cells and their patterns of gene expression in living organisms can increase our understanding of tissue development and disease. Gene reporters for bioluminescence, fluorescence, radionuclide, and magnetic resonance imaging (MRI) have been described but these suffer various...
  11. Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.

    Nature Medicine 20(1):93 (2014) PMID 24317119 PMCID PMC3886895

    In this study, we monitored glycolysis in mouse lymphoma and lung tumors by measuring the conversion of hyperpolarized [U-2H, U-13C]glucose to lactate using 13C magnetic resonance spectroscopy and spectroscopic imaging. We observed labeled lactate only in tumors and not in surrounding normal tis...
  12. Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment.

    Magnetic Resonance in Medicine 71(1):402 (2014) PMID 23440731

    The acquisition of ever increasing volumes of high resolution magnetic resonance imaging (MRI) data has created an urgent need to develop automated and objective image analysis algorithms that can assist in determining tumor margins, diagnosing tumor stage, and detecting treatment response. We h...
  13. Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.

    Nature Medicine 20(1):93 (2014) PMID 24317119 PMCID PMC3886895

    In this study, we monitored glycolysis in mouse lymphoma and lung tumors by measuring the conversion of hyperpolarized [U-2H, U-13C]glucose to lactate using 13C magnetic resonance spectroscopy and spectroscopic imaging. We observed labeled lactate only in tumors and not in surrounding normal tis...
  14. Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons.

    Contrast Media and Molecular Imaging 9(2):182 (2014) PMID 24523064 PMCID PMC4265858

    The spin polarization-induced nuclear Overhauser effect (SPINOE) describes the enhancement of spin polarization of solvent nuclei by the hyperpolarized spins of a solute. In this communication we demonstrate that SPINOEs can be observed between [1,4-(13) C2 ]fumarate, hyperpolarized using the di...
  15. Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment.

    Magnetic Resonance in Medicine 71(1):402 (2014) PMID 23440731

    The acquisition of ever increasing volumes of high resolution magnetic resonance imaging (MRI) data has created an urgent need to develop automated and objective image analysis algorithms that can assist in determining tumor margins, diagnosing tumor stage, and detecting treatment response. We h...
  16. Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.

    Nature Medicine 20(1):93 (2014) PMID 24317119 PMCID PMC3886895

    In this study, we monitored glycolysis in mouse lymphoma and lung tumors by measuring the conversion of hyperpolarized [U-2H, U-13C]glucose to lactate using 13C magnetic resonance spectroscopy and spectroscopic imaging. We observed labeled lactate only in tumors and not in surrounding normal tis...
  17. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  18. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  19. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  20. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...