1. Activation of serotonin2C receptors in the lateral habenular nucleus increases the expression of depression-related behaviors in the hemiparkinsonian rat

    Neuropharmacology 93:68 (2015)

    The roles of lateral habenular nucleus (LHb) glutamate neurons and serotonin2C (5-HT2C) receptors in depression are poorly understood, particularly in Parkinson's disease-associated depression. Here we assessed the importance of LHb glutamate neurons and 5-HT2C receptors for depressive...
  2. Effect of Ca2 + species with different modes of occurrence on direct liquefaction of a calcium-rich lignite

    Fuel Processing Technology 133:161 (2015)

    Low-rank coals concurrently contain organically bound alkali and alkaline earth metals (AAEM species) and discrete mineral matters. In this work, the influences of exchangeable calcium cations and discrete calcium salts on direct liquefaction of a Ca2+-rich lignite were investigated. T...
  3. Effect of Ca2 + species with different modes of occurrence on direct liquefaction of a calcium-rich lignite

    Fuel Processing Technology 133:161 (2015)

    Low-rank coals concurrently contain organically bound alkali and alkaline earth metals (AAEM species) and discrete mineral matters. In this work, the influences of exchangeable calcium cations and discrete calcium salts on direct liquefaction of a Ca2+-rich lignite were investigated. T...
  4. Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.

    Medical Oncology 32(5):609 (2015) PMID 25832867

    The oncogenic role of ubiquitin-conjugating enzyme E2C (UBE2C) had been identified in some types of human tumors, while the clinical and biological role of UBE2C in non-small cell lung cancer (NSCLC) is still elusive. Here, we have determined the specific role of UBE2C in NSCLC. Western blot and...
  5. DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/β-catenin signaling.

    Oncotarget 6(11):8621 (2015) PMID 25940701 PMCID PMC4496171

    The cell fate determination factor Dachshund (DACH1) functions as a novel suppressor in the progression of various neoplasms. Previous study has suggested that hypermethylation of promoter region was responsible for the reduction of DACH1 expression in hepatocellular carcinoma (HCC), and associa...
  6. A special healing pattern in stable metaphyseal fractures.

    Acta Orthopaedica (Print Edition) 86(2):238 (2015) PMID 25582035 PMCID PMC4404778

    Metaphyseal fractures heal in a rapid fashion that is different from the bone shaft healing process. Animal studies have focused on diaphyseal fractures. We investigated the metaphyseal fracture-healing process in rabbits. 60 rabbits (divided into 12 groups) underwent proximal tibial osteotomy, ...
  7. Activation of serotonin2A receptors in the medial septum-diagonal band of Broca complex enhanced working memory in the hemiparkinsonian rats.

    Neuropharmacology 91:23 (2015) PMID 25486618

    Serotonin2A (5-HT2A) receptors are highly expressed in the medial septum-diagonal band of Broca complex (MS-DB), especially in parvalbumin (PV)-positive neurons linked to hippocampal theta rhythm, which is involved in cognition. Cognitive impairments commonly occur in Parkinson's disease. Here w...
  8. Co-Culture of α TC-6 Cells and β TC-1 Cells: Morphology and Function.

    Endocrinology and Metabolism 30(1):92 (2015) PMID 25325280 PMCID PMC4384678

    In vitro experiments using only β-cell lines instead of islets are limited because pancreatic islets are composed of four different types of endocrine cells. Several recent studies have focused on cellular interactions among these cell types, especially α- and β-cells. Because islet isolation ne...
  9. DACH1 inhibits lung adenocarcinoma invasion and tumor growth by repressing CXCL5 signaling.

    Oncotarget 6(8):5877 (2015) PMID 25788272 PMCID PMC4467408

    Whole-genome and transcriptome sequencing of non-small cell lung cancer (NSCLC) identified that DACH1, is a human homolog of drosophila gene dac, is involved in NSCLC. Here we showed that expression of DACH1 was significantly decreased in human NSCLC tissues and DACH1 abundance was inversely cor...
  10. Beneficial effects of neomangiferin on high fat diet-induced nonalcoholic fatty liver disease in rats

    International Immunopharmacology 25(1):218 (2015)

    This study was carried out to determine the effect and mechanism of action of neomangiferin (NG) on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in rats. NAFLD rats were randomly assigned into several groups of equal number. NG (50, 25mg/kg·day−1 BW) and lipanthyl (PT...
  11. Colivelin ameliorates amyloid β peptide-induced impairments in spatial memory, synaptic plasticity, and calcium homeostasis in rats.

    Hippocampus 25(3):363 (2015) PMID 25332198

    Amyloid β peptide (Aβ) has been thought to be neurotoxic and responsible for the impairment of learning and memory in Alzheimer's disease (AD). Humanin (HN), a 24 amino acid polypeptide first identified from the unaffected occipital lobe of an AD patient, is believed to be neuroprotective agains...
  12. Beneficial effects of neomangiferin on high fat diet-induced nonalcoholic fatty liver disease in rats.

    International Immunopharmacology 25(1):218 (2015) PMID 25661699

    This study was carried out to determine the effect and mechanism of action of neomangiferin (NG) on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in rats. NAFLD rats were randomly assigned into several groups of equal number. NG (50, 25mg/kg·day(-1) BW) and lipanthyl (PT, 5mg/kg...
  13. Beneficial effects of neomangiferin on high fat diet-induced nonalcoholic fatty liver disease in rats.

    International Immunopharmacology 25(1):218 (2015) PMID 25661699

    This study was carried out to determine the effect and mechanism of action of neomangiferin (NG) on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in rats. NAFLD rats were randomly assigned into several groups of equal number. NG (50, 25mg/kg·day(-1) BW) and lipanthyl (PT, 5mg/kg...
  14. Formation of a built-in field at the porphyrin/ITO interface directly proven by the time-resolved photovoltage technique.

    Physical Chemistry Chemical Physics 17(7):5202 (2015) PMID 25601105

    Two assemblies, porphyrin powder/ITO and porphyrin film/ITO, were built by a facile method. The time-resolved photovoltage technique was utilized to prove the behaviour of photo-induced charges in the two assemblies. The photovoltage results show that the porphyrin film/ITO assembly displays a r...
  15. TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo.

    Steroids 94:51 (2015) PMID 25555472

    Non-small cell lung cancer is the most common type of lung cancer and the most common cause of cancer-related death in humans. TXA9, which is a natural product separated from an anti-tumor-active fraction of the roots of Streptocaulon juventas, may possess potent anti-proliferative activity acco...
  16. The effect of proton pump inhibitors on glycated hemoglobin levels in patients with type 2 diabetes mellitus.

    Canadian Journal of Diabetes 39(1):24 (2015) PMID 25305802

    Gastrin increases the growth and neogenesis of the islets of Langerhans. Oral proton pump inhibitors (PPIs) increase the circulating gastrin level in animals and humans, but the therapeutic benefit of PPIs for diabetes mellitus has not been resolved. We examined whether treatment with a PPI for ...
  17. Diabetic Myonecrosis in a Patient with Hepatitis B-Induced Liver Cirrhosis

    Canadian Journal of Diabetes 39(1):10 (2015) PMID 25305801

    Diabetic myonecrosis—a rare complication of long-standing, poorly controlled diabetes mellitus—typically presents with acute-onset muscle pain, is self-limiting, and responds well to conservative management. We report a case of diabetic myonecrosis in a 33-year-old man with h...
  18. Diabetic myonecrosis in a patient with hepatitis B-induced liver cirrhosis.

    Canadian Journal of Diabetes 39(1):10 (2015) PMID 25305801

    Diabetic myonecrosis-a rare complication of long-standing, poorly controlled diabetes mellitus-typically presents with acute-onset muscle pain, is self-limiting, and responds well to conservative management. We report a case of diabetic myonecrosis in a 33-year-old man with hepatitis B-induced l...
  19. Anxiolytic effects of prelimbic 5-HT1A receptor activation in the hemiparkinsonian rat.

    Behavioural Brain Research 277:211 (2015) PMID 24906197

    This study sought to assess whether unilateral lesions of the medial forebrain bundle (MFB) using 6-hydroxydopamine in rats are able to induce anxiety-like behaviors, the role of serotonin-1A (5-HT1A) receptors of the prelimbic (PrL) sub-region of ventral medial prefrontal cortex in the regulati...
  20. Anxiolytic effects of prelimbic 5-HT(1A) receptor activation in the hemiparkinsonian rat.

    Behavioural Brain Research 277:211 (2015) PMID 24906197

    This study sought to assess whether unilateral lesions of the medial forebrain bundle (MFB) using 6-hydroxydopamine in rats are able to induce anxiety-like behaviors, the role of serotonin-1A (5-HT1A) receptors of the prelimbic (PrL) sub-region of ventral medial prefrontal cortex in the regulati...