1. Translation and cancer.

    Biochimica et Biophysica Acta 1849(7):751 (2015) PMID 25988403

  2. Light-regulated translational control of circadian behavior by eIF4E phosphorylation.

    Nature Neuroscience 18(6):855 (2015) PMID 25915475 PMCID PMC4446158

    The circadian (∼24 h) clock is continuously entrained (reset) by ambient light so that endogenous rhythms are synchronized with daily changes in the environment. Light-induced gene expression is thought to be the molecular mechanism underlying clock entrainment. mRNA translation is a key step of...
  3. DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation.

    Nucleic Acids Research 43(7):3764 (2015) PMID 25779044 PMCID PMC4402527

    Initiation is a highly regulated rate-limiting step of mRNA translation. During cap-dependent translation, the cap-binding protein eIF4E recruits the mRNA to the ribosome. Specific elements in the 5'UTR of some mRNAs referred to as Internal Ribosome Entry Sites (IRESes) allow direct association ...
  4. G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.

    Journal of Cell Biology 209(1):73 (2015) PMID 25847539 PMCID PMC4395486

    G3BP1, a target of TDP-43, is required for normal stress granule (SG) assembly, but the functional consequences of failed SG assembly remain unknown. Here, using both transformed cell lines and primary neurons, we investigated the functional impact of this disruption in SG dynamics. While stress...
  5. The long unfinished march towards understanding microRNA-mediated repression.

    RNA 21(4):519 (2015) PMID 25780122 PMCID PMC4371264

  6. Targeting the translation machinery in cancer.

    Nature Reviews: Drug Discovery 14(4):261 (2015) PMID 25743081

    Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and tumour suppressors affect the translation machinery, making aberrant translation a widespread characteristic of tumour cells, independent of the genetic make-up of the cancer. Therefore, therapeutic agents t...
  7. Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.

    Nature 519(7541):106 (2015) PMID 25533957

    Intrinsically disordered proteins play important roles in cell signalling, transcription, translation and cell cycle regulation. Although they lack stable tertiary structure, many intrinsically disordered proteins undergo disorder-to-order transitions upon binding to partners. Similarly, several...
  8. Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.

    Nature 519(7541):106 (2015) PMID 25533957

    Intrinsically disordered proteins play important roles in cell signalling, transcription, translation and cell cycle regulation. Although they lack stable tertiary structure, many intrinsically disordered proteins undergo disorder-to-order transitions upon binding to partners. Similarly, several...
  9. Translational Tolerance of Mitochondrial Genes to Metabolic Energy Stress Involves TISU and eIF1-eIF4GI Cooperation in Start Codon Selection.

    Cell Metabolism 21(3):479 (2015) PMID 25738462

    Protein synthesis is a major energy-consuming process, which is rapidly repressed upon energy stress by AMPK. How energy deficiency affects translation of mRNAs that cope with the stress response is poorly understood. We found that mitochondrial genes remain translationally active upon energy de...
  10. Translational Tolerance of Mitochondrial Genes to Metabolic Energy Stress Involves TISU and eIF1-eIF4GI Cooperation in Start Codon Selection.

    Cell Metabolism 21(3):479 (2015) PMID 25738462

    Protein synthesis is a major energy-consuming process, which is rapidly repressed upon energy stress by AMPK. How energy deficiency affects translation of mRNAs that cope with the stress response is poorly understood. We found that mitochondrial genes remain translationally active upon energy de...
  11. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

    Nature 517(7535):497 (2015) PMID 25383520 PMCID PMC4304784

    Inactivation of APC is a strongly predisposing event in the development of colorectal cancer, prompting the search for vulnerabilities specific to cells that have lost APC function. Signalling through the mTOR pathway is known to be required for epithelial cell proliferation and tumour growth, a...
  12. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

    Nature 517(7535):497 (2015) PMID 25383520 PMCID PMC4304784

    Inactivation of APC is a strongly predisposing event in the development of colorectal cancer, prompting the search for vulnerabilities specific to cells that have lost APC function. Signalling through the mTOR pathway is known to be required for epithelial cell proliferation and tumour growth, a...
  13. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

    Nature 517(7535):497 (2015) PMID 25383520

    Inactivation of APC is a strongly predisposing event in the development of colorectal cancer, prompting the search for vulnerabilities specific to cells that have lost APC function. Signalling through the mTOR pathway is known to be required for epithelial cell proliferation and tumour growth, a...
  14. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

    Nature 517(7535):497 (2015) PMID 25383520 PMCID PMC4304784

    Inactivation of APC is a strongly predisposing event in the development of colorectal cancer, prompting the search for vulnerabilities specific to cells that have lost APC function. Signalling through the mTOR pathway is known to be required for epithelial cell proliferation and tumour growth, a...
  15. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

    Nature 517(7535):497 (2015) PMID 25383520 PMCID PMC4304784

    Inactivation of APC is a strongly predisposing event in the development of colorectal cancer, prompting the search for vulnerabilities specific to cells that have lost APC function. Signalling through the mTOR pathway is known to be required for epithelial cell proliferation and tumour growth, a...
  16. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

    Nature 517(7535):497 (2015) PMID 25383520 PMCID PMC4304784

    Inactivation of APC is a strongly predisposing event in the development of colorectal cancer, prompting the search for vulnerabilities specific to cells that have lost APC function. Signalling through the mTOR pathway is known to be required for epithelial cell proliferation and tumour growth, a...
  17. Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.

    Cancer Research 75(2):250 (2015) PMID 25593033 PMCID PMC4299928

    Elevated protein synthesis is an important feature of many cancer cells and often arises as a consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F), the key regulator of the mRNA-ribosome recruitment phase of translation initiation. In many cellular and pre...
  18. Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.

    Cancer Research 75(2):250 (2015) PMID 25593033

    Elevated protein synthesis is an important feature of many cancer cells and often arises as a consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F), the key regulator of the mRNA-ribosome recruitment phase of translation initiation. In many cellular and pre...
  19. Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.

    Cancer Research 75(2):250 (2015) PMID 25593033 PMCID PMC4299928

    Elevated protein synthesis is an important feature of many cancer cells and often arises as a consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F), the key regulator of the mRNA-ribosome recruitment phase of translation initiation. In many cellular and pre...
  20. Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.

    PLoS ONE 10(4):e0123352 (2015) PMID 25923732 PMCID PMC4414544

    Phosphorylation of the eukaryotic translation initiation factor eIF4E is associated with malignant progression and poor cancer prognosis. Accordingly, here we have analyzed the association between eIF4E phosphorylation and cellular resistance to oxidative stress, starvation, and DNA-damaging age...