1. The 2016 revision of the World Health Organization classification of lymphoid neoplasms.

    Blood 127(20):2375 (2016) PMID 26980727 PMCID PMC4874220

    A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the additi...
  2. Diffuse Large B-Cell Lymphoma Version 1.2016.

    Journal of the National Comprehensive Cancer Ne... 14(2):196 (2016) PMID 26850490

    Diffuse large B-cell lymphomas (DLBCL) are now considered a heterogeneous group of distinct molecular subtypes (germinal center B-cell DLBCL, activated B-cell DLBCL, and primary mediastinal large B-cell lymphoma (PMBL) with varied natural history and response to therapy. In addition, a subset of...
  3. IgG4-related Orbital Disease and Its Mimics in a Western Population.

    The American Journal of Surgical Pathology 39(12):1688 (2015) PMID 26379149

    Although chronic inflammatory disorders of the ocular adnexa are relatively common, their pathogenesis is in many cases poorly understood. Recent investigation suggests that many cases of sclerosing orbital inflammation are a manifestation of IgG4-related disease; however, most patients reported...
  4. Case 12-2015: A Newborn Boy with Respiratory Distress, Lethargy, and Hypernatremia

    New England Journal of Medicine 372(16):1550 (2015) PMID 25875261

    A newborn boy was admitted to the hospital because of respiratory distress and hypotension. At delivery, meconium was suctioned from the airway. Respiration and blood pressure improved after intervention, but lethargy and myoclonus developed. Presentation of Case Dr...
  5. Case 11-2015: A 28-Year-Old Woman with Headache, Fever, and a Rash

    New England Journal of Medicine 372(15):1454 (2015) PMID 25853750

    A 28-year-old woman was seen in the emergency department of this hospital because of the acute onset of headache, fever, rash, and myalgias. On examination, she had petechiae on the chest, abdomen, and thighs and a purpuric lesion on the right shoulder. Presentation of Case ...
  6. Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia

    New England Journal of Medicine 372(15):1430 (2015) PMID 25853747

    Background MYD88L265P and CXCR4WHIM mutations are highly prevalent in Waldenström’s macroglobulinemia. MYD88L265P triggers tumor-cell growth through Bruton’s tyrosine kinase, a target of ibrutinib. CXCR4WHIM mutations confer in vitro resistance to ibrutinib.
  7. Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia

    New England Journal of Medicine 372(15):1430 (2015) PMID 25853747

    Background MYD88L265P and CXCR4WHIM mutations are highly prevalent in Waldenström’s macroglobulinemia. MYD88L265P triggers tumor-cell growth through Bruton’s tyrosine kinase, a target of ibrutinib. CXCR4WHIM mutations confer in vitro resistance to ibrutinib.
  8. Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia

    New England Journal of Medicine 372(15):1430 (2015) PMID 25853747

    Background MYD88L265P and CXCR4WHIM mutations are highly prevalent in Waldenström’s macroglobulinemia. MYD88L265P triggers tumor-cell growth through Bruton’s tyrosine kinase, a target of ibrutinib. CXCR4WHIM mutations confer in vitro resistance to ibrutinib.
  9. Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia

    New England Journal of Medicine 372(15):1430 (2015) PMID 25853747

    Background MYD88L265P and CXCR4WHIM mutations are highly prevalent in Waldenström’s macroglobulinemia. MYD88L265P triggers tumor-cell growth through Bruton’s tyrosine kinase, a target of ibrutinib. CXCR4WHIM mutations confer in vitro resistance to ibrutinib.
  10. Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 1.2015.

    Journal of the National Comprehensive Cancer Ne... 13(3):326 (2015) PMID 25736010 PMCID PMC4841457

    Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are different manifestations of the same disease, which are managed in the same way. The advent of novel monoclonal antibodies (ofatumumab and obinutuzumab) led to the development of effective chemoimmunotherapy regimens. Th...
  11. Indolent lymphoma: follicular lymphoma and the microenvironment-insights from the microscope.

    ASH Education Program Book 2014(1):158 (2014) PMID 25696849

    Follicular lymphomas (FLs) are neoplasms of germinal center (GC) B cells, which retain many of the morphologic, immunophenotypic, genetic, and functional features of normal GC B cells. Both normal GCs and neoplastic follicles of FL also contain non-neoplastic cells (microenvironment) that influe...
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  12. Case 34-2014: A 7-Year-Old Boy with Focal Seizures and Progressive Weakness

    New England Journal of Medicine 371(18):1737 (2014) PMID 25354108

    A 7-year-old boy was evaluated because of focal seizures, twitching of the right arm and the right side of the face, and progressive weakness. Imaging revealed progressive left cortical atrophy and a focal lesion in the left parietal cortex. A diagnostic procedure was performed. ...
  13. Cytotoxic T-cell and NK-cell lymphomas: current questions and controversies.

    The American Journal of Surgical Pathology 38(10):e60 (2014) PMID 25025449

    The cytotoxic T-cell and natural killer (NK)-cell lymphomas and related disorders are important but relatively rare lymphoid neoplasms that frequently are a challenge for practicing pathologists. This selective review, based on a meeting of the International Lymphoma Study Group, briefly reviews...
  14. Intralymphatic cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis: expanding the spectrum of CD30-positive lymphoproliferative disorders.

    The American Journal of Surgical Pathology 38(9):1203 (2014) PMID 24805854

    Intravascular large B-cell lymphomas and EBV NK/T-cell lymphomas commonly follow an aggressive clinical course. We recently reported an entirely intravascular anaplastic large cell lymphoma (ALCL) in the skin with a surprisingly indolent clinical course; interestingly, this lymphoma involved the...
  15. Non-Hodgkin's lymphomas, version 4.2014.

    Journal of the National Comprehensive Cancer Ne... 12(9):1282 (2014) PMID 25190696 PMCID PMC4839265

    Non-Hodgkin's lymphomas (NHL) are a heterogeneous group of lymphoproliferative disorders originating in B lymphocytes, T lymphocytes, or natural killer cells. Mantle cell lymphoma (MCL) accounts for approximately 6% of all newly diagnosed NHL cases. Radiation therapy with or without systemic the...
  16. Non-Hodgkin's lymphomas, version 2.2014.

    Journal of the National Comprehensive Cancer Ne... 12(6):916 (2014) PMID 24925202

    Non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of lymphoproliferative disorders originating in B lymphocytes, T lymphocytes, or natural killer cells. Follicular lymphoma (FL) is the most common subtype of indolent NHL, accounting for approximately 22% of all newly diagnosed cases of NH...
  17. Case 14-2014:An 11-Month-Old Girl with Developmental Delay

    New England Journal of Medicine 370(19):1830 (2014) PMID 24806163

    An 11-month-old girl was seen in the neurology clinic because of developmental delay. Development to 6 months was normal; by 11 months, she had difficulty sitting and had stopped reaching for objects and feeding herself. An examination and diagnostic tests were performed. Pre...
  18. EBV may be expressed in the LP cells of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) in both children and adults.

    The American Journal of Surgical Pathology 38(3):316 (2014) PMID 24525501 PMCID PMC3927152

    Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and classical Hodgkin lymphoma (CHL) are classified separately because of their distinct clinical and pathologic features. Whereas Epstein-Barr virus (EBV) is detected in the neoplastic cells of 25% to 70% of CHL, NLPHL is generally conside...
  19. Peripheral T-cell lymphomas with cytotoxic phenotype in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.

    The American Journal of Surgical Pathology 38(2):279 (2014) PMID 24418862

    Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is relatively common, and patients occasionally develop other neoplasms; however, patients who develop other types of lymphomas are rare. We encountered 3 patients with CLL/SLL (one 59-y-old man and 2 women aged 56 and 66 y) who d...
  20. The heavy chain diseases: clinical and pathologic features.

    Oncology (Williston Park, N.Y.) 28(1):45 (2014) PMID 24683718

    Heavy chain diseases are a family of rare, systemic syndromes typically associated with or representing a variant of a B-cell neoplasm. Their characteristic feature is production of a mutated immunoglobulin heavy chain incapable of either partnering with light chains in the formation of a full i...