1. Response to comment on "cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans".

    Journal of Immunology 194(8):3533 (2015) PMID 25848069

  2. Cutting Edge: Epigenetic Regulation of Foxp3 Defines a Stable Population of CD4+ Regulatory T Cells in Tumors from Mice and Humans.

    Journal of Immunology 194(3):878 (2015) PMID 25548231

    CD4(+) regulatory T cells (Tregs) are critical for maintaining self-tolerance and function to prevent autoimmune disease. High densities of intratumoral Tregs are generally associated with poor patient prognosis, a correlation attributed to their broad immune-suppressive features. Two major popu...
  3. Cutting Edge: Epigenetic Regulation of Foxp3 Defines a Stable Population of CD4+ Regulatory T Cells in Tumors from Mice and Humans.

    Journal of Immunology 194(3):878 (2015) PMID 25548231 PMCID PMC4298129

    CD4(+) regulatory T cells (Tregs) are critical for maintaining self-tolerance and function to prevent autoimmune disease. High densities of intratumoral Tregs are generally associated with poor patient prognosis, a correlation attributed to their broad immune-suppressive features. Two major popu...
  4. Cutting Edge: Epigenetic Regulation of Foxp3 Defines a Stable Population of CD4+ Regulatory T Cells in Tumors from Mice and Humans.

    Journal of Immunology 194(3):878 (2015) PMID 25548231 PMCID PMC4298129

    CD4(+) regulatory T cells (Tregs) are critical for maintaining self-tolerance and function to prevent autoimmune disease. High densities of intratumoral Tregs are generally associated with poor patient prognosis, a correlation attributed to their broad immune-suppressive features. Two major popu...
  5. Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans.

    Journal of Immunology 194(3):878 (2015) PMID 25548231 PMCID PMC4298129

    CD4(+) regulatory T cells (Tregs) are critical for maintaining self-tolerance and function to prevent autoimmune disease. High densities of intratumoral Tregs are generally associated with poor patient prognosis, a correlation attributed to their broad immune-suppressive features. Two major popu...
  6. Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans.

    Journal of Immunology 194(3):878 (2015) PMID 25548231 PMCID PMC4298129

    CD4(+) regulatory T cells (Tregs) are critical for maintaining self-tolerance and function to prevent autoimmune disease. High densities of intratumoral Tregs are generally associated with poor patient prognosis, a correlation attributed to their broad immune-suppressive features. Two major popu...
  7. OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy.

    Immunology and Cell Biology 92(6):475 (2014) PMID 24732076

    Antibodies targeting checkpoint inhibitors or co-stimulatory receptors on T cells have shown significant antitumor efficacy in preclinical and clinical studies. In mouse tumor models, engagement of activating Fcγ receptor (FcγR)-expressing immune cells was recently shown to be required for the t...
  8. OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy.

    Immunology and Cell Biology 92(6):475 (2014) PMID 24732076

    Antibodies targeting checkpoint inhibitors or co-stimulatory receptors on T cells have shown significant antitumor efficacy in preclinical and clinical studies. In mouse tumor models, engagement of activating Fcγ receptor (FcγR)-expressing immune cells was recently shown to be required for the t...
  9. OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy.

    Immunology and Cell Biology 92(6):475 (2014) PMID 24732076

    Antibodies targeting checkpoint inhibitors or co-stimulatory receptors on T cells have shown significant antitumor efficacy in preclinical and clinical studies. In mouse tumor models, engagement of activating Fcγ receptor (FcγR)-expressing immune cells was recently shown to be required for the t...
  10. Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant.

    Journal of Immunology 192(7):3259 (2014) PMID 24610009

    Adjuvants are an essential component of modern vaccines and used for their ability to elicit immunity to coadministered Ags. Many adjuvants in clinical development are particulates, but how they drive innate and adaptive immune responses remains poorly understood. Studies have shown that a numbe...
  11. Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant.

    Journal of Immunology 192(7):3259 (2014) PMID 24610009

    Adjuvants are an essential component of modern vaccines and used for their ability to elicit immunity to coadministered Ags. Many adjuvants in clinical development are particulates, but how they drive innate and adaptive immune responses remains poorly understood. Studies have shown that a numbe...
  12. Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies.

    Journal of Experimental Medicine 210(9):1685 (2013) PMID 23897982 PMCID PMC3754864

    Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that target tumor necrosis factor receptor (TNFR) family members have shown dependence on expression of the inhibitory FcγR, FcγRIIB. It remains unclear if ...
  13. Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies.

    Journal of Experimental Medicine 210(9):1685 (2013) PMID 23897982 PMCID PMC3754864

    Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that target tumor necrosis factor receptor (TNFR) family members have shown dependence on expression of the inhibitory FcγR, FcγRIIB. It remains unclear if ...
  14. Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies.

    Journal of Experimental Medicine 210(9):1685 (2013) PMID 23897982 PMCID PMC3754864

    Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that target tumor necrosis factor receptor (TNFR) family members have shown dependence on expression of the inhibitory FcγR, FcγRIIB. It remains unclear if ...
  15. Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages.

    Immunology and Cell Biology 91(7):451 (2013) PMID 23817579 PMCID PMC3736205

    Toll-like receptors (TLRs) enable metazoans to mount effective innate immune responses to microbial and viral pathogens, as well as to endogenous host-derived ligands. It is understood that genetic background of the host can influence TLR responsiveness, altering susceptibility to pathogen infec...
  16. Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages.

    Immunology and Cell Biology 91(7):451 (2013) PMID 23817579 PMCID PMC3736205

    Toll-like receptors (TLRs) enable metazoans to mount effective innate immune responses to microbial and viral pathogens, as well as to endogenous host-derived ligands. It is understood that genetic background of the host can influence TLR responsiveness, altering susceptibility to pathogen infec...
  17. Proapoptotic Activation of Death Receptor 5 on Tumor Endothelial Cells Disrupts the Vasculature and Reduces Tumor Growth

    Cancer Cell 22(1):80 (2012)

    The proapoptotic death receptor DR5 has been studied extensively in cancer cells, but its action in the tumor microenvironment is not well defined. Here, we uncover a role for DR5 signaling in tumor endothelial cells (ECs). We detected DR5 expression in ECs within tumors but not normal...
  18. Proapoptotic activation of death receptor 5 on tumor endothelial cells disrupts the vasculature and reduces tumor growth.

    Cancer Cell 22(1):80 (2012) PMID 22789540

    The proapoptotic death receptor DR5 has been studied extensively in cancer cells, but its action in the tumor microenvironment is not well defined. Here, we uncover a role for DR5 signaling in tumor endothelial cells (ECs). We detected DR5 expression in ECs within tumors but not normal tissues. ...
  19. ISCOMATRIX vaccines mediate CD8+ T-cell cross-priming by a MyD88-dependent signaling pathway.

    Immunology and Cell Biology 90(5):540 (2012) PMID 21894173 PMCID PMC3365289

    Generating a cytotoxic CD8(+) T-cell response that can eradicate malignant cells is the primary objective of cancer vaccine strategies. In this study we have characterized the innate and adaptive immune response to the ISCOMATRIX adjuvant, and the ability of vaccine antigens formulated with this...
  20. ISCOMATRIX vaccines mediate CD8+ T-cell cross-priming by a MyD88-dependent signaling pathway.

    Immunology and Cell Biology 90(5):540 (2012) PMID 21894173 PMCID PMC3365289

    Generating a cytotoxic CD8(+) T-cell response that can eradicate malignant cells is the primary objective of cancer vaccine strategies. In this study we have characterized the innate and adaptive immune response to the ISCOMATRIX adjuvant, and the ability of vaccine antigens formulated with this...