1. NPY signalling in early osteoblasts controls glucose homeostasis.

    Molecular Metabolism 4(3):164 (2015) PMID 25737952 PMCID PMC4338316

    The skeleton has recently emerged as an additional player in the control of whole-body glucose metabolism; however, the mechanism behind this is not clear. Here we employ mice lacking neuropeptide Y, Y1 receptors solely in cells of the early osteoblastic lineage (Y1f3.6Cre), to examine the role ...
  2. Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice.

    Neuropeptides 48(3):143 (2014) PMID 24680736

    Orexigenic neuropeptide Y (NPY) and dynorphin (DYN) regulate energy homeostasis. Single NPY or dynorphin deletion reduces food intake or increases fat loss. Future developments of obesity therapeutics involve targeting multiple pathways. We hypothesised that NPY and dynorphin regulate energy hom...
  3. Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice

    Neuropeptides 48(3):143 (2014)

    Objective Orexigenic neuropeptide Y (NPY) and dynorphin (DYN) regulate energy homeostasis. Single NPY or dynorphin deletion reduces food intake or increases fat loss. Future developments of obesity therapeutics involve targeting multiple pathways. We hypothesised that NPY and...
  4. Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice.

    Neuropeptides 48(3):143 (2014) PMID 24680736

    Orexigenic neuropeptide Y (NPY) and dynorphin (DYN) regulate energy homeostasis. Single NPY or dynorphin deletion reduces food intake or increases fat loss. Future developments of obesity therapeutics involve targeting multiple pathways. We hypothesised that NPY and dynorphin regulate energy hom...
  5. Osteoblast specific Y1 receptor deletion enhances bone mass.

    Bone 48(3):461 (2011) PMID 21040809

    Neuropeptide Y, Y1 receptors are found in neuronal as well as bone tissue and Y1 signalling has been implicated in the regulation of bone mass. However, the contribution of Y1 receptors located in these different tissues, particularly that of the bone-specific Y1 receptors, to the regulation of ...
  6. Osteoblast specific Y1 receptor deletion enhances bone mass.

    Bone 48(3):461 (2011) PMID 21040809

    Neuropeptide Y, Y1 receptors are found in neuronal as well as bone tissue and Y1 signalling has been implicated in the regulation of bone mass. However, the contribution of Y1 receptors located in these different tissues, particularly that of the bone-specific Y1 receptors, to the regulation of ...
  7. Y2 and Y4 receptor signalling attenuates the skeletal response of central NPY.

    Journal of Molecular Neuroscience 43(2):123 (2011) PMID 20635164

    Both the neuropeptide Y (NPY) and the leptin systems have been shown to be important central mediators of bone metabolism. However, the interaction between these two systems is complex and not fully understood. Here, we show that a unique interaction exists between Y2 and Y4 receptors in the reg...
  8. Y2 and Y4 receptor signalling attenuates the skeletal response of central NPY.

    Journal of Molecular Neuroscience 43(2):123 (2011) PMID 20635164

    Both the neuropeptide Y (NPY) and the leptin systems have been shown to be important central mediators of bone metabolism. However, the interaction between these two systems is complex and not fully understood. Here, we show that a unique interaction exists between Y2 and Y4 receptors in the reg...
  9. Osteoblast specific Y1 receptor deletion enhances bone mass

    Bone 48(3):461 (2011)

    Neuropeptide Y, Y1 receptors are found in neuronal as well as bone tissue and Y1 signalling has been implicated in the regulation of bone mass. However, the contribution of Y1 receptors located in these different tissues, particularly that of the bone-specific Y1 receptors, to the regulatio...
  10. Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity.

    Journal of Bone and Mineral Research 25(8):1736 (2010) PMID 20200977

    The neuropeptide Y (NPY) system has been implicated in the regulation of bone homeostasis and osteoblast activity, but the mechanism behind this is unclear. Here we show that Y1 receptor signaling is directly involved in the differentiation of mesenchymal progenitor cells isolated from bone tiss...
  11. Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity.

    Journal of Bone and Mineral Research 25(8):1736 (2010) PMID 20200977

    The neuropeptide Y (NPY) system has been implicated in the regulation of bone homeostasis and osteoblast activity, but the mechanism behind this is unclear. Here we show that Y1 receptor signaling is directly involved in the differentiation of mesenchymal progenitor cells isolated from bone tiss...
  12. NPY regulation of bone remodelling.

    Neuropeptides 43(6):457 (2009) PMID 19748118

    Neuropeptide Y (NPY), a classic neuronal regulator of energy homeostasis, is now also known to be involved in the control of bone homeostasis. Of the five known Y receptors through which the NPY family of ligands signals, the Y1 and Y2 receptors have so far been implicated in the control of oste...
  13. NPY regulation of bone remodelling.

    Neuropeptides 43(6):457 (2009) PMID 19748118

    Neuropeptide Y (NPY), a classic neuronal regulator of energy homeostasis, is now also known to be involved in the control of bone homeostasis. Of the five known Y receptors through which the NPY family of ligands signals, the Y1 and Y2 receptors have so far been implicated in the control of oste...
  14. Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight.

    PLoS ONE 4(12):e8415 (2009) PMID 20027231 PMCID PMC2794533

    Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the regulation of bone mass in a manner consistent with the central perception of energy status. Mice lacking neuropeptide Y (NPY), a well-kno...
  15. NPY regulation of bone remodelling

    Neuropeptides 43(6):457 (2009)

    Neuropeptide Y (NPY), a classic neuronal regulator of energy homeostasis, is now also known to be involved in the control of bone homeostasis. Of the five known Y receptors through which the NPY family of ligands signals, the Y1 and Y2 receptors have so far been implicated in the control of...
  16. Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight.

    PLoS ONE 4(12):e8415 (2009) PMID 20027231 PMCID PMC2794533

    Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the regulation of bone mass in a manner consistent with the central perception of energy status. Mice lacking neuropeptide Y (NPY), a well-kno...
  17. Synergistic attenuation of obesity by Y2- and Y4-receptor double knockout in ob/ob mice.

    Nutrition 24(9):892 (2008) PMID 18662863

    Neuropeptide Y regulates numerous processes including food intake, body composition, and reproduction by at least five different Y receptors. We previously demonstrated a synergistic interaction between Y2 and Y4 receptors in reducing adiposity in chow- or fat-fed Y2Y4-receptor double-knockout m...
  18. Synergistic attenuation of obesity by Y2- and Y4-receptor double knockout in ob/ob mice.

    Nutrition 24(9):892 (2008) PMID 18662863

    Neuropeptide Y regulates numerous processes including food intake, body composition, and reproduction by at least five different Y receptors. We previously demonstrated a synergistic interaction between Y2 and Y4 receptors in reducing adiposity in chow- or fat-fed Y2Y4-receptor double-knockout m...
  19. Leptin as an endocrine signal in bone.

    Current Osteoporosis Reports 6(2):62 (2008) PMID 18778565

    Leptin and its actions in bone came to prominence in 2000, with the publication of two landmark articles identifying a novel interaction between energy and bone homeostasis, as well as a novel hypothalamic circuit to the skeleton. However, they also revealed the dichotomous nature of leptin's ef...
  20. Leptin as an endocrine signal in bone.

    Current Osteoporosis Reports 6(2):62 (2008) PMID 18778565

    Leptin and its actions in bone came to prominence in 2000, with the publication of two landmark articles identifying a novel interaction between energy and bone homeostasis, as well as a novel hypothalamic circuit to the skeleton. However, they also revealed the dichotomous nature of leptin's ef...