1. Preventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthma.

    EXCLI Journal 12:184 (2013) PMID 26417226 PMCID PMC4531779

    Oxidative stress appears to have an important role in glucocorticoid insensitivity, as a crucial problem in asthma therapy. We studied the preventive effect of antioxidant N-acetylcysteine (NAC) on the airway hyper-responsiveness (AHR) and the accumulation of inflammatory cells in the airways in...
  2. Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway.

    Journal of Immunology 186(10):5938 (2011) PMID 21482736 PMCID PMC3404606

    Human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in infants. In human infants, plasmacytoid dendritic cells (pDC) are recruited to the nasal compartment during infection and initiate host defense through the secretion of type I IFN, IL-12, and IL-...
  3. Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice.

    Respiratory Research 11:14 (2010) PMID 20122285 PMCID PMC2842242

    Early-life respiratory viral infections, notably with respiratory syncytial virus (RSV), increase the risk of subsequent development of childhood asthma. The purpose of this study was to assess whether early-life infection with a species-specific model of RSV and subsequent allergen exposure pre...
  4. Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma.

    American Journal of Respiratory Cell and Molecu... 39(5):543 (2008) PMID 18474669 PMCID PMC2643207

    Neutrophilic inflammation in acute exacerbations of asthma tends to be resistant to treatment with glucocorticoids. This may be related to decreased activity and expression of histone deacetylase-2 (HDAC2), which down-regulates expression of proinflammatory genes via recruitment to the glucocort...
  5. Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease.

    Nature Medicine 13(11):1308 (2007) PMID 17934471

    The role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in immune responses mediated by T-helper 2 (T(H)2) lymphocytes is unknown. Here we characterize the development of allergic airway disease in TRAIL-deficient (Tnfsf10(-/-)) mice and in mice exposed to short interfering R...
  6. Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammation.

    American Journal of Respiratory Cell and Molecu... 35(5):565 (2006) PMID 16794258

    We have developed an animal model to investigate the mechanisms underlying an acute exacerbation of chronic asthma. Sensitized BALB/c mice were exposed to aerosolized ovalbumin, either as chronic low-level challenge (mass concentration approximately 3 mg/m(3)) for 4 wk, a single moderate-level c...