1. Small-conductance Ca(2+)-activated K(+) channels and cardiac arrhythmias.

    Heart Rhythm 12(8):1845 (2015) PMID 25956967

    Small-conductance Ca(2+)-activated K(+) (SK, KCa2) channels are unique in that they are gated solely by changes in intracellular Ca(2+) and, hence, function to integrate intracellular Ca(2+) and membrane potentials on a beat-to-beat basis. Recent studies have provided evidence for the existence ...
  2. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice.

    Toxicology and Applied Pharmacology 286(2):102 (2015) PMID 25827057 PMCID PMC4458210

    Liver fibrosis is a pathological condition in which chronic inflammation and changes to the extracellular matrix lead to alterations in hepatic tissue architecture and functional degradation of the liver. Inhibitors of the enzyme soluble epoxide hydrolase (sEH) reduce fibrosis in the heart, panc...
  3. Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis

    Atherosclerosis 239(2):557 (2015)

    Adipose tissue is the body largest free cholesterol reservoir and abundantly expresses ATP binding cassette transporter A1 (ABCA1), which maintains plasma high-density lipoprotein (HDL) levels. HDLs have a protective role in atherosclerosis by mediating reverse cholesterol transport (R...
  4. Na(+) channel function, regulation, structure, trafficking and sequestration.

    Journal of Physiology 593(6):1347 (2015) PMID 25772290 PMCID PMC4376415

    This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation-contraction coupling and arrhythmias: Na(+) channel and Na(+) transport. The goal of...
  5. Identification of a key residue in Kv7.1 potassium channel essential for sensing external potassium ions.

    Journal of General Physiology 145(3):201 (2015) PMID 25712016 PMCID PMC4338162

    Kv7.1 voltage-gated K(+) (Kv) channels are present in the apical membranes of marginal cells of the stria vascularis of the inner ear, where they mediate K(+) efflux into the scala media (cochlear duct) of the cochlea. As such, they are exposed to the K(+)-rich (∼150 mM of external K(+) (K(+) e)...
  6. Identification of a key residue in Kv7.1 potassium channel essential for sensing external potassium ions.

    Journal of General Physiology 145(3):201 (2015) PMID 25712016

    Kv7.1 voltage-gated K(+) (Kv) channels are present in the apical membranes of marginal cells of the stria vascularis of the inner ear, where they mediate K(+) efflux into the scala media (cochlear duct) of the cochlea. As such, they are exposed to the K(+)-rich (∼150 mM of external K(+) (K(+) e)...
  7. Identification of a key residue in Kv7.1 potassium channel essential for sensing external potassium ions.

    Journal of General Physiology 145(3):201 (2015) PMID 25712016 PMCID PMC4338162

    Kv7.1 voltage-gated K(+) (Kv) channels are present in the apical membranes of marginal cells of the stria vascularis of the inner ear, where they mediate K(+) efflux into the scala media (cochlear duct) of the cochlea. As such, they are exposed to the K(+)-rich (∼150 mM of external K(+) (K(+) e)...
  8. Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A.

    PNAS 112(8):2575 (2015) PMID 25675481 PMCID PMC4345570

    The developmental rehearsal for the debut of hearing is marked by massive changes in the membrane properties of hair cells (HCs) and spiral ganglion neurons (SGNs). Whereas the underlying mechanisms for the developing HC transition to mature stage are understood in detail, the maturation of SGNs...
  9. Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A.

    PNAS 112(8):2575 (2015) PMID 25675481 PMCID PMC4345570

    The developmental rehearsal for the debut of hearing is marked by massive changes in the membrane properties of hair cells (HCs) and spiral ganglion neurons (SGNs). Whereas the underlying mechanisms for the developing HC transition to mature stage are understood in detail, the maturation of SGNs...
  10. Regulation of Gene Transcription by Voltage-gated L-type Calcium Channel, Cav1.3.

    Journal of Biological Chemistry 290(8):4663 (2015) PMID 25538241

    Cav1.3 L-type Ca(2+) channel is known to be highly expressed in neurons and neuroendocrine cells. However, we have previously demonstrated that the Cav1.3 channel is also expressed in atria and pacemaking cells in the heart. The significance of the tissue-specific expression of the channel is un...
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  11. Regulation of Gene Transcription by Voltage-gated L-type Calcium Channel, Cav1.3.

    Journal of Biological Chemistry 290(8):4663 (2015) PMID 25538241 PMCID PMC4335206

    Cav1.3 L-type Ca(2+) channel is known to be highly expressed in neurons and neuroendocrine cells. However, we have previously demonstrated that the Cav1.3 channel is also expressed in atria and pacemaking cells in the heart. The significance of the tissue-specific expression of the channel is un...
  12. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3.

    Journal of Biological Chemistry 290(8):4663 (2015) PMID 25538241 PMCID PMC4335206

    Cav1.3 L-type Ca(2+) channel is known to be highly expressed in neurons and neuroendocrine cells. However, we have previously demonstrated that the Cav1.3 channel is also expressed in atria and pacemaking cells in the heart. The significance of the tissue-specific expression of the channel is un...
  13. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013.

    Heart Rhythm 12(1):e5 (2015) PMID 25460864

  14. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013.

    Heart Rhythm 12(1):e5 (2015) PMID 25460864

  15. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9–10, 2013

    Heart Rhythm 12(1):e5 (2015)

  16. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013.

    Heart Rhythm 12(1):e5 (2015) PMID 25460864 PMCID PMC4425127

  17. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013.

    Heart Rhythm 12(1):e5 (2015) PMID 25460864

  18. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013.

    Heart Rhythm 12(1):e5 (2015) PMID 25460864

  19. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model.

    Journal of the American Heart Association Cardi... 3(4) (2014) PMID 25146704 PMCID PMC4310392

    Chronic hypersecretion of the pancreatic hormone amylin is common in humans with obesity or prediabetic insulin resistance and induces amylin aggregation and proteotoxicity in the pancreas. We recently showed that hyperamylinemia also affects the cardiovascular system. Here, we investigated whet...
  20. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model.

    Journal of the American Heart Association Cardi... 3(4) (2014) PMID 25146704 PMCID PMC4310392

    Chronic hypersecretion of the pancreatic hormone amylin is common in humans with obesity or prediabetic insulin resistance and induces amylin aggregation and proteotoxicity in the pancreas. We recently showed that hyperamylinemia also affects the cardiovascular system. Here, we investigated whet...