1. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation.

    Circulation: Arrhythmia and Electrophysiology 9(5) (2016) PMID 27162031 PMCID PMC4869994

    Atrial fibrillation represents the most common arrhythmia leading to increased morbidity and mortality, yet, current treatment strategies have proven inadequate. Conventional treatment with antiarrhythmic drugs carries a high risk for proarrhythmias. The soluble epoxide hydrolase enzyme catalyze...
  2. Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels.

    Journal of Biological Chemistry 291(5):2499 (2016) PMID 26515070 PMCID PMC4732230

    Calmodulin (CaM), a Ca(2+)-sensing protein, is constitutively bound to IQ domains of the C termini of human Kv7 (hKv7, KCNQ) channels to mediate Ca(2+)-dependent reduction of Kv7 currents. However, the mechanism remains unclear. We report that CaM binds to two isoforms of the hKv7.4 channel in a...
  3. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes.

    Circulation Research 118(2):e19 (2016) PMID 26643875 PMCID PMC4740258

    Cardiac myocyte contraction is caused by Ca(2+) binding to troponin C, which triggers the cross-bridge power stroke and myofilament sliding in sarcomeres. Synchronized Ca(2+) release causes whole cell contraction and is readily observable with current microscopy techniques. However, it is unknow...
  4. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models.

    PLoS ONE 11(8):e0160605 (2016) PMID 27500929

    Isolation of high quality cardiomyocytes is critically important for achieving successful experiments in many cellular and molecular cardiology studies. Methods for isolating cardiomyocytes from the murine heart generally are time-sensitive and experience-dependent, and often fail to produce hig...
  5. Aerobic exercise-based rehabilitation affects the activities of progenitor endothelial cells through EETs pathway.

    Medical Hypotheses 85(6):1037 (2015) PMID 26454561

  6. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling.

    Circulation: Arrhythmia and Electrophysiology 8(4):942 (2015) PMID 25995211 PMCID PMC4545299

    Loss of transient outward K(+) current (Ito) is well documented in cardiac hypertrophy and failure both in animal models and in humans. Electrical remodeling contributes to prolonged action potential duration and increased incidence of arrhythmias. Furthermore, there is a growing body of evidenc...
  7. Small-conductance Ca2+ -activated K+ channels and cardiac arrhythmias.

    Heart Rhythm 12(8):1845 (2015) PMID 25956967 PMCID PMC4662728

    Small-conductance Ca2+ -activated K+ (SK, KCa2) channels are unique in that they are gated solely by changes in intracellular Ca2+ and, hence, function to integrate intracellular Ca2+ and membrane potentials on a beat-to-beat basis. Recent studies have provided evidence for the existence and fun...
  8. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice.

    Toxicology and Applied Pharmacology 286(2):102 (2015) PMID 25827057 PMCID PMC4458210

    Liver fibrosis is a pathological condition in which chronic inflammation and changes to the extracellular matrix lead to alterations in hepatic tissue architecture and functional degradation of the liver. Inhibitors of the enzyme soluble epoxide hydrolase (sEH) reduce fibrosis in the heart, panc...
  9. Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis.

    Atherosclerosis 239(2):557 (2015) PMID 25733327 PMCID PMC4527317

    Adipose tissue is the body largest free cholesterol reservoir and abundantly expresses ATP binding cassette transporter A1 (ABCA1), which maintains plasma high-density lipoprotein (HDL) levels. HDLs have a protective role in atherosclerosis by mediating reverse cholesterol transport (RCT). Solub...
  10. Na+ channel function, regulation, structure, trafficking and sequestration.

    Journal of Physiology 593(6):1347 (2015) PMID 25772290 PMCID PMC4376415

    This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation-contraction coupling and arrhythmias: Na(+) channel and Na(+) transport. The goal of...
  11. Identification of a key residue in Kv7.1 potassium channel essential for sensing external potassium ions.

    Journal of General Physiology 145(3):201 (2015) PMID 25712016 PMCID PMC4338162

    Kv7.1 voltage-gated K(+) (Kv) channels are present in the apical membranes of marginal cells of the stria vascularis of the inner ear, where they mediate K(+) efflux into the scala media (cochlear duct) of the cochlea. As such, they are exposed to the K(+)-rich (∼ 150 mM of external K(+) (K(+) e...
  12. Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A.

    PNAS 112(8):2575 (2015) PMID 25675481 PMCID PMC4345570

    The developmental rehearsal for the debut of hearing is marked by massive changes in the membrane properties of hair cells (HCs) and spiral ganglion neurons (SGNs). Whereas the underlying mechanisms for the developing HC transition to mature stage are understood in detail, the maturation of SGNs...
  13. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3.

    Journal of Biological Chemistry 290(8):4663 (2015) PMID 25538241 PMCID PMC4335206

    Cav1.3 L-type Ca(2+) channel is known to be highly expressed in neurons and neuroendocrine cells. However, we have previously demonstrated that the Cav1.3 channel is also expressed in atria and pacemaking cells in the heart. The significance of the tissue-specific expression of the channel is un...
  14. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013.

    Heart Rhythm 12(1):e5 (2015) PMID 25460864 PMCID PMC4425127

  15. Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel.

    PNAS 111(27):9989 (2014) PMID 24951510 PMCID PMC4103345

    For an excitable cell to function properly, a precise number of ion channel proteins need to be trafficked to distinct locations on the cell surface membrane, through a network and anchoring activity of cytoskeletal proteins. Not surprisingly, mutations in anchoring proteins have profound effect...
  16. Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.

    Journal of Neuroscience 34(21):7383 (2014) PMID 24849370 PMCID PMC4028507

    Spiral ganglion neurons (SGNs) of the eighth nerve serve as the bridge between hair cells and the cochlear nucleus. Hair cells use Cav1.3 as the primary channel for Ca(2+) inflow to mediate transmitter release. In contrast, SGNs are equipped with multiple Ca(2+) channels to mediate Ca(2+)-depend...
  17. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling.

    Science Signaling 7(317):ra27 (2014) PMID 24643800 PMCID PMC4103414

    Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an afterload during cardiomyocyte contraction, we found that nitric oxide synthase (NOS) was involved in transducing mechanica...
  18. Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.

    Cardiovascular Research 101(2):317 (2014) PMID 24282291 PMCID PMC3896251

    Small conductance Ca(2+)-activated K(+) channels (K(Ca)2 or SK channels) have been reported in excitable cells, where they aid in integrating changes in intracellular Ca(2+) (Ca(i)²⁺) with membrane potentials. We have recently reported the functional expression of SK channels in human and mouse ...
  19. Localized Nitric Oxide Signaling Mediates Cardiac Mechano-Chemotransduction

    Biophysical Journal 106(2):566a (2014)

  20. A-Actinin2 and Filamin a Cytoskeletal Interacting Proteins Facilitate SK2 Channels Recycling from Endosomes to the Surface Membrane

    Biophysical Journal 106(2):118a (2014)