1. S-7 : A new cytokine receptor activation paradigm: Activation of JAK2 by the growth hormone receptor

    Cytokine 70(1):22 (2014)

    The conformational changes required to transmit the GH binding signal from the extracellular domain of the GH receptor to its intracellular domain resulting in activation of JAK2 has been enigmatic. We have recently defined the first complete mechanistic model for JAK2 activation based...
  2. Mechanism of activation of protein kinase JAK2 by the growth hormone receptor.

    Science 344(6185):1249783 (2014) PMID 24833397

    Signaling from JAK (Janus kinase) protein kinases to STAT (signal transducers and activators of transcription) transcription factors is key to many aspects of biology and medicine, yet the mechanism by which cytokine receptors initiate signaling is enigmatic. We present a complete mechanistic mo...
  3. Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

    PLoS ONE 8(9):e74706 (2013) PMID 24069332 PMCID PMC3771900

    Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potenti...
  4. Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

    PLoS ONE 8(9):e74706 (2013) PMID 24069332 PMCID PMC3771900

    Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potenti...
  5. Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

    PLoS ONE 8(9):e74706 (2013) PMID 24069332 PMCID PMC3771900

    Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potenti...
  6. Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

    PLoS ONE 8(9):e74706 (2013) PMID 24069332 PMCID PMC3771900

    Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potenti...
  7. Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

    PLoS ONE 8(9):e74706 (2013) PMID 24069332 PMCID PMC3771900

    Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potenti...
  8. Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

    PLoS ONE 8(9):e74706 (2013) PMID 24069332 PMCID PMC3771900

    Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potenti...
  9. Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

    PLoS ONE 8(9):e74706 (2013) PMID 24069332 PMCID PMC3771900

    Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potenti...
  10. Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

    PLoS ONE 8(9):e74706 (2013) PMID 24069332 PMCID PMC3771900

    Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potenti...
  11. Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

    PLoS ONE 8(9):e74706 (2013) PMID 24069332 PMCID PMC3771900

    Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potenti...
  12. Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

    PLoS ONE 8(9):e74706 (2013) PMID 24069332 PMCID PMC3771900

    Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potenti...
  13. Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network.

    Addiction Biology 17(1):1 (2012) PMID 21955143

    Addiction is a chronic brain disorder. Prolonged abstinence from drugs of abuse involves dysphoria, high stress responsiveness and craving. The neurobiology of drug abstinence, however, is poorly understood. We previously identified a unique set of hundred mu-opioid receptor-dependent genes in t...
  14. Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network.

    Addiction Biology 17(1):1 (2012) PMID 21955143

    Addiction is a chronic brain disorder. Prolonged abstinence from drugs of abuse involves dysphoria, high stress responsiveness and craving. The neurobiology of drug abstinence, however, is poorly understood. We previously identified a unique set of hundred mu-opioid receptor-dependent genes in t...
  15. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence.

    Addiction Biology 16(4):615 (2011) PMID 21392173 PMCID PMC3139763

    Alcoholism is characterized by a progressive loss of control over ethanol intake. The purpose of this study was to identify transcriptional changes selectively associated with excessive ethanol drinking in dependent mice, as opposed to non-dependent mice maintaining a stable voluntary consumptio...
  16. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence.

    Addiction Biology 16(4):615 (2011) PMID 21392173 PMCID PMC3139763

    Alcoholism is characterized by a progressive loss of control over ethanol intake. The purpose of this study was to identify transcriptional changes selectively associated with excessive ethanol drinking in dependent mice, as opposed to non-dependent mice maintaining a stable voluntary consumptio...