1. Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation.

    Hepatology 56(1):209 (2012) PMID 22290718

    Obstructive cholestasis induces liver injury, postoperative complications, and mortality after surgery. Adaptive control of cholestasis, including bile salt homeostasis, is necessary for recovery and survival. Peripheral serotonin is a cytoprotective neurotransmitter also associated with liver r...
  2. Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation.

    Hepatology 56(1):209 (2012) PMID 22290718

    Obstructive cholestasis induces liver injury, postoperative complications, and mortality after surgery. Adaptive control of cholestasis, including bile salt homeostasis, is necessary for recovery and survival. Peripheral serotonin is a cytoprotective neurotransmitter also associated with liver r...
  3. Partial bile duct ligation in mice: a novel model of acute cholestasis.

    Surgery 149(3):445 (2011) PMID 20817234

    The standard model for research in cholestasis is the total ligation of the bile duct (tBDL). Because this model causes severe hepatic injury in mice, we developed a novel model of cholestasis using a partial bile duct ligation (pBDL) and evaluate different mechanisms of injury. Male C57Bl/6 mic...
  4. Partial bile duct ligation in mice: a novel model of acute cholestasis.

    Surgery 149(3):445 (2011) PMID 20817234

    The standard model for research in cholestasis is the total ligation of the bile duct (tBDL). Because this model causes severe hepatic injury in mice, we developed a novel model of cholestasis using a partial bile duct ligation (pBDL) and evaluate different mechanisms of injury. Male C57Bl/6 mic...
  5. Partial bile duct ligation in mice: A novel model of acute cholestasis

    Surgery 149(3):445 (2011) PMID 20817234

    Background The standard model for research in cholestasis is the total ligation of the bile duct (tBDL). Because this model causes severe hepatic injury in mice, we developed a novel model of cholestasis using a partial bile duct ligation (pBDL) and evaluate different mechanisms of inj...
  6. Partial bile duct ligation in mice: A novel model of acute cholestasis

    Surgery 149(3):445 (2011)

    Background The standard model for research in cholestasis is the total ligation of the bile duct (tBDL). Because this model causes severe hepatic injury in mice, we developed a novel model of cholestasis using a partial bile duct ligation (pBDL) and evaluate different mechanisms of inj...
  7. Aggravation of viral hepatitis by platelet-derived serotonin.

    Nature Medicine 14(7):756 (2008) PMID 18516052

    More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in liver steatosis, liver cirrhosis, end-stag...
  8. Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts.

    Cancer Research 68(13):5152 (2008) PMID 18593914

    Serotonin, a neurotransmitter with numerous functions in the central nervous system (CNS), is emerging as an important signaling molecule in biological processes outside of the CNS. Recent advances have implicated serotonin as a regulator of inflammation, proliferation, regeneration, and repair....
  9. Aggravation of viral hepatitis by platelet-derived serotonin.

    Nature Medicine 14(7):756 (2008) PMID 18516052

    More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in liver steatosis, liver cirrhosis, end-stag...
  10. Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts.

    Cancer Research 68(13):5152 (2008) PMID 18593914

    Serotonin, a neurotransmitter with numerous functions in the central nervous system (CNS), is emerging as an important signaling molecule in biological processes outside of the CNS. Recent advances have implicated serotonin as a regulator of inflammation, proliferation, regeneration, and repair....
  11. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation.

    Nature Medicine 13(11):1316 (2007) PMID 17982463

    T helper cells can support the functions of CD8(+) T cells against persistently infecting viruses such as murine lymphocytic choriomeningitis virus (LCMV), cytomegalovirus, hepatitis C virus and HIV. These viruses often resist complete elimination and remain detectable at sanctuary sites, such a...
  12. Routine stenting reduces urologic complications as compared with stenting "on demand" in adult kidney transplantation.

    Urology 70(5):893 (2007) PMID 17919691

    To examine the impact of the chosen surgical technique and of systematic versus "on-demand" placement of a primary stent on the incidence of urologic complications in adult kidney transplantation. Data of 497 consecutive patients undergoing kidney transplantation at a single center were retrospe...
  13. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation.

    Nature Medicine 13(11):1316 (2007) PMID 17982463

    T helper cells can support the functions of CD8(+) T cells against persistently infecting viruses such as murine lymphocytic choriomeningitis virus (LCMV), cytomegalovirus, hepatitis C virus and HIV. These viruses often resist complete elimination and remain detectable at sanctuary sites, such a...
  14. Routine stenting reduces urologic complications as compared with stenting "on demand" in adult kidney transplantation.

    Urology 70(5):893 (2007) PMID 17919691

    To examine the impact of the chosen surgical technique and of systematic versus "on-demand" placement of a primary stent on the incidence of urologic complications in adult kidney transplantation. Data of 497 consecutive patients undergoing kidney transplantation at a single center were retrospe...
  15. Serotonin Mediates Oxidative Stress and Mitochondrial Toxicity in a Murine Model of Nonalcoholic Steatohepatitis

    Gastroenterology 133(2):608 (2007)

    Background & Aims: Nonalcoholic steatohepatitis (NASH) is one of the most common causes of liver enzyme elevation in the West. Its prevalence is likely to increase further, paralleling the epidemic increase of the metabolic syndrome. Serotonin degradation by monoamine oxidase A (MAO-A)...
  16. Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.

    Gastroenterology 133(2):608 (2007) PMID 17681180

    Nonalcoholic steatohepatitis (NASH) is one of the most common causes of liver enzyme elevation in the West. Its prevalence is likely to increase further, paralleling the epidemic increase of the metabolic syndrome. Serotonin degradation by monoamine oxidase A (MAO-A) was recently implicated as a...
  17. Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.

    Gastroenterology 133(2):608 (2007) PMID 17681180

    Nonalcoholic steatohepatitis (NASH) is one of the most common causes of liver enzyme elevation in the West. Its prevalence is likely to increase further, paralleling the epidemic increase of the metabolic syndrome. Serotonin degradation by monoamine oxidase A (MAO-A) was recently implicated as a...
  18. Liver graft protection by antiapoptotic drugs: a step further.

    Liver Transplantation 13(3):318 (2007) PMID 17318874

  19. Liver graft protection by antiapoptotic drugs: a step further.

    Liver Transplantation 13(3):318 (2007) PMID 17318874

  20. Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice.

    Hepatology 45(2):369 (2007) PMID 17256748

    Hepatic ischemia and reperfusion (I/R) leads to the formation of leukocyte-platelet aggregates. Upon activation, platelets generate reactive oxygen species and release proapoptotic and proinflammatory mediators as well as growth factors. In cold hepatic ischemia, adhesion of platelets to endothe...