Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation.
Hepatology 56(1):209 (2012)
Obstructive cholestasis induces liver injury, postoperative complications, and mortality after surgery. Adaptive control of cholestasis, including bile salt homeostasis, is necessary for recovery and survival. Peripheral serotonin is a cytoprotective neurotransmitter also associated with liver r...
Partial bile duct ligation in mice: a novel model of acute cholestasis.
Surgery 149(3):445 (2011)
The standard model for research in cholestasis is the total ligation of the bile duct (tBDL). Because this model causes severe hepatic injury in mice, we developed a novel model of cholestasis using a partial bile duct ligation (pBDL) and evaluate different mechanisms of injury.
Male C57Bl/6 mic...
Aggravation of viral hepatitis by platelet-derived serotonin.
Nature Medicine 14(7):756 (2008)
More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in liver steatosis, liver cirrhosis, end-stag...
Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts.
Cancer Research 68(13):5152 (2008)
Serotonin, a neurotransmitter with numerous functions in the central nervous system (CNS), is emerging as an important signaling molecule in biological processes outside of the CNS. Recent advances have implicated serotonin as a regulator of inflammation, proliferation, regeneration, and repair....
Routine stenting reduces urologic complications as compared with stenting "on demand" in adult kidney transplantation.
Urology 70(5):893 (2007)
To examine the impact of the chosen surgical technique and of systematic versus "on-demand" placement of a primary stent on the incidence of urologic complications in adult kidney transplantation.
Data of 497 consecutive patients undergoing kidney transplantation at a single center were retrospe...
Extralymphatic virus sanctuaries as a consequence of potent T-cell activation.
Nature Medicine 13(11):1316 (2007)
T helper cells can support the functions of CD8(+) T cells against persistently infecting viruses such as murine lymphocytic choriomeningitis virus (LCMV), cytomegalovirus, hepatitis C virus and HIV. These viruses often resist complete elimination and remain detectable at sanctuary sites, such a...
Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.
Gastroenterology 133(2):608 (2007)
Nonalcoholic steatohepatitis (NASH) is one of the most common causes of liver enzyme elevation in the West. Its prevalence is likely to increase further, paralleling the epidemic increase of the metabolic syndrome. Serotonin degradation by monoamine oxidase A (MAO-A) was recently implicated as a...
Serotonin Mediates Oxidative Stress and Mitochondrial Toxicity in a Murine Model of Nonalcoholic Steatohepatitis
Gastroenterology 133(2):608 (2007)
Background & Aims: Nonalcoholic steatohepatitis (NASH) is one of the most common causes of liver enzyme elevation in the West. Its prevalence is likely to increase further, paralleling the epidemic increase of the metabolic syndrome. Serotonin degradation by monoamine oxidase A (MAO-A)...
Liver graft protection by antiapoptotic drugs: a step further.
Liver Transplantation 13(3):318 (2007)
Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice.
Hepatology 45(2):369 (2007)
Hepatic ischemia and reperfusion (I/R) leads to the formation of leukocyte-platelet aggregates. Upon activation, platelets generate reactive oxygen species and release proapoptotic and proinflammatory mediators as well as growth factors. In cold hepatic ischemia, adhesion of platelets to endothe...
Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses.
PNAS 103(42):15535 (2006)
The reason why severe localized or systemic virus infections enhance and aggravate bacterial superinfection is poorly understood. Here we show that virus-induced IFN type I caused apoptosis in bone marrow granulocytes, drastically reduced granulocyte infiltrates at the site of bacterial superinf...
Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.
Journal of Clinical Investigation 116(9):2456 (2006)
The liver is known to be a classical immunoprivileged site with a relatively high resistance against immune responses. Here we demonstrate that highly activated liver-specific effector CD8+ T cells alone were not sufficient to trigger immune destruction of the liver in mice. Only additional inna...
Kupffer cell-dependent TNF-alpha signaling mediates injury in the arterialized small-for-size liver transplantation in the mouse.
PNAS 103(12):4598 (2006)
Implantation of small liver grafts causes liver injury and defective regeneration leading to graft failure. We investigated whether Kupffer cell-dependent TNF-alpha signaling contributes to this poor outcome. Partial 30% liver transplantation was performed in C57BL/6 wild-type mice (control grou...
Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications.
American Journal of Transplantation 5(11):2605 (2005)
Widespread application of cadaveric split or living donor liver transplantation bears considerable potential to increase the pool of available organs and thus alleviate the problem of organ shortage. Although splitting of a cadaveric liver into two grafts for adult recipients can be performed su...