1. Vitamin D, muscle and bone: Integrating effects in development, aging and injury.

    Molecular and Cellular Endocrinology 410:3 (2015) PMID 25837735

    Beyond the established effects of muscle loading on bone, a complex network of hormones and growth factors integrates these adjacent tissues. One such hormone, vitamin D, exerts broad-ranging effects in muscle and bone calcium handling, differentiation and development. Vitamin D also modulates m...
  2. NPY signalling in early osteoblasts controls glucose homeostasis.

    Molecular Metabolism 4(3):164 (2015) PMID 25737952 PMCID PMC4338316

    The skeleton has recently emerged as an additional player in the control of whole-body glucose metabolism; however, the mechanism behind this is not clear. Here we employ mice lacking neuropeptide Y, Y1 receptors solely in cells of the early osteoblastic lineage (Y1f3.6Cre), to examine the role ...
  3. Stress- and diet-induced fat gain is controlled by NPY in catecholaminergic neurons.

    Molecular Metabolism 3(5):581 (2014) PMID 25061562 PMCID PMC4099511

    Neuropeptide Y (NPY) and noradrenaline are commonly co-expressed in sympathetic neurons. Both are key regulators of energy homeostasis and critical for stress-coping. However, little is known about the specific function of NPY in the catecholaminergic system in these regulations. Here we show th...
  4. Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice.

    Neuropeptides 48(3):143 (2014) PMID 24680736

    Orexigenic neuropeptide Y (NPY) and dynorphin (DYN) regulate energy homeostasis. Single NPY or dynorphin deletion reduces food intake or increases fat loss. Future developments of obesity therapeutics involve targeting multiple pathways. We hypothesised that NPY and dynorphin regulate energy hom...
  5. Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice

    Neuropeptides 48(3):143 (2014)

    Objective Orexigenic neuropeptide Y (NPY) and dynorphin (DYN) regulate energy homeostasis. Single NPY or dynorphin deletion reduces food intake or increases fat loss. Future developments of obesity therapeutics involve targeting multiple pathways. We hypothesised that NPY and...
  6. Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice.

    Neuropeptides 48(3):143 (2014) PMID 24680736

    Orexigenic neuropeptide Y (NPY) and dynorphin (DYN) regulate energy homeostasis. Single NPY or dynorphin deletion reduces food intake or increases fat loss. Future developments of obesity therapeutics involve targeting multiple pathways. We hypothesised that NPY and dynorphin regulate energy hom...
  7. The hunger games of skeletal metabolism.

    BoneKEy Reports 3:588 (2014) PMID 25396052 PMCID PMC4230187

    Gastrointestinal peptides and adipokines are critical signalling molecules involved in controlling whole-body energy homeostasis. These circulating hormones regulate a variety of biological responses such as hunger, satiety and glucose uptake. In vivo experiments have established that these horm...
  8. The hunger games of skeletal metabolism.

    BoneKEy Reports 3:588 (2014) PMID 25396052 PMCID PMC4230187

    Gastrointestinal peptides and adipokines are critical signalling molecules involved in controlling whole-body energy homeostasis. These circulating hormones regulate a variety of biological responses such as hunger, satiety and glucose uptake. In vivo experiments have established that these horm...
  9. Neuropeptide Y modulates fracture healing through Y1 receptor signaling.

    Journal of Orthopaedic Research 31(10):1570 (2013) PMID 23733357

    Neuropeptide Y acting via it's Y1 receptor represents a powerful pathway in the control of bone mass. The global or osteoblast-specific Y1 receptor deletion induces pronounced bone anabolic effects in mice. However, the contribution of Y1 receptor deletion in bone repair/healing remained to be c...
  10. Neuropeptide Y modulates fracture healing through Y1 receptor signaling.

    Journal of Orthopaedic Research 31(10):1570 (2013) PMID 23733357

    Neuropeptide Y acting via it's Y1 receptor represents a powerful pathway in the control of bone mass. The global or osteoblast-specific Y1 receptor deletion induces pronounced bone anabolic effects in mice. However, the contribution of Y1 receptor deletion in bone repair/healing remained to be c...
  11. Influence of hormonal appetite and energy regulators on bone.

    Current Osteoporosis Reports 11(3):194 (2013) PMID 23913000

    Nutritional status is an essential component in determining whole body energy homeostasis. The balance between energy/food intake and metabolism is governed by a range of hormones secreted from various parts of the body. Their subsequent dissemination via the blood results in a wide range of bio...
  12. Influence of hormonal appetite and energy regulators on bone.

    Current Osteoporosis Reports 11(3):194 (2013) PMID 23913000

    Nutritional status is an essential component in determining whole body energy homeostasis. The balance between energy/food intake and metabolism is governed by a range of hormones secreted from various parts of the body. Their subsequent dissemination via the blood results in a wide range of bio...
  13. Matrix metalloproteinase-driven endochondral fracture union proceeds independently of osteoclast activity.

    Journal of Bone and Mineral Research 28(7):1550 (2013) PMID 23408642

    As new insights into the complexities of endochondral fracture repair emerge, the temporal role of osteoclast activity remains ambiguous. With numerous antiresorptive agents available to treat bone disease, understanding their impact on bone repair is vital. Further, in light of recent work sugg...
  14. Matrix metalloproteinase-driven endochondral fracture union proceeds independently of osteoclast activity.

    Journal of Bone and Mineral Research 28(7):1550 (2013) PMID 23408642

    As new insights into the complexities of endochondral fracture repair emerge, the temporal role of osteoclast activity remains ambiguous. With numerous antiresorptive agents available to treat bone disease, understanding their impact on bone repair is vital. Further, in light of recent work sugg...
  15. Neuropeptide Y is a critical modulator of leptin's regulation of cortical bone.

    Journal of Bone and Mineral Research 28(4):886 (2013) PMID 23044938

    Leptin signaling is required for normal bone homeostasis; however, loss of leptin results in differing effects on cortical and cancellous bone, as well as altered responses between the axial and appendicular regions. Local β-adrenergic actions are responsible for the greater cancellous bone volu...
  16. Neuropeptide Y is a critical modulator of leptin's regulation of cortical bone.

    Journal of Bone and Mineral Research 28(4):886 (2013) PMID 23044938

    Leptin signaling is required for normal bone homeostasis; however, loss of leptin results in differing effects on cortical and cancellous bone, as well as altered responses between the axial and appendicular regions. Local β-adrenergic actions are responsible for the greater cancellous bone volu...
  17. Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN.

    Cell Metabolism 17(2):236 (2013) PMID 23395170

    Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is...
  18. Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN.

    Cell Metabolism 17(2):236 (2013) PMID 23395170

    Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is...
  19. Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN

    Cell Metabolism 17(2):236 (2013)

    Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleu...
  20. Bone muscle interactions and vitamin D

    Bone (2013)

    Beyond the established roles of vitamin D in bone and mineral homeostasis, we are becoming increasingly aware of its diverse effects in skeletal muscle. Subjects with severe vitamin D deficiency or mutations of the vitamin D receptor develop generalized atrophy of muscle and bone, sugg...