1. Quantitative Reduction of the TCR Adapter Protein SLP-76 Unbalances Immunity and Immune Regulation.

    Journal of Immunology 194(6):2587 (2015) PMID 25662996

    Gene variants that disrupt TCR signaling can cause severe immune deficiency, yet less disruptive variants are sometimes associated with immune pathology. Null mutations of the gene encoding the scaffold protein Src homology 2 domain-containing leukocyte protein of 76 kDa (SLP-76), for example, c...
  2. Dual proinflammatory and antiviral properties of pulmonary eosinophils in respiratory syncytial virus vaccine-enhanced disease.

    Journal of Virology 89(3):1564 (2015) PMID 25410867 PMCID PMC4300751

    Human respiratory syncytial virus (RSV) is a major cause of morbidity and severe lower respiratory tract disease in the elderly and very young, with some infants developing bronchiolitis, recurrent wheezing, and asthma following infection. Previous studies in humans and animal models have shown ...
  3. Dual proinflammatory and antiviral properties of pulmonary eosinophils in respiratory syncytial virus vaccine-enhanced disease.

    Journal of Virology 89(3):1564 (2015) PMID 25410867

    Human respiratory syncytial virus (RSV) is a major cause of morbidity and severe lower respiratory tract disease in the elderly and very young, with some infants developing bronchiolitis, recurrent wheezing, and asthma following infection. Previous studies in humans and animal models have shown ...
  4. Dual proinflammatory and antiviral properties of pulmonary eosinophils in respiratory syncytial virus vaccine-enhanced disease.

    Journal of Virology 89(3):1564 (2015) PMID 25410867 PMCID PMC4300751

    Human respiratory syncytial virus (RSV) is a major cause of morbidity and severe lower respiratory tract disease in the elderly and very young, with some infants developing bronchiolitis, recurrent wheezing, and asthma following infection. Previous studies in humans and animal models have shown ...
  5. MicroRNA Function in Mast Cell Biology: Protocols to Characterize and Modulate MicroRNA Expression.

    Methods in Molecular Biology 1220:287 (2015) PMID 25388258

    MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs occurs through imperfect base pairing between an miRNA and its target, meaning that each miRNA can target a number of ...
  6. MicroRNA function in mast cell biology: protocols to characterize and modulate microRNA expression.

    Methods in Molecular Biology 1220:287 (2015) PMID 25388258

    MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs occurs through imperfect base pairing between an miRNA and its target, meaning that each miRNA can target a number of ...
  7. Asthma 2014: from monoclonals to the microbiome

    The Lancet Respiratory Medicine 2(12):956 (2014)

  8. MicroRNA: potential biomarkers and therapeutic targets for allergic asthma?

    Annals of Medicine 46(8):633 (2014) PMID 25307360

    MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and differentiation). However, ...
  9. Asthma 2014: from monoclonals to the microbiome.

    The lancet. Respiratory medicine 2(12):956 (2014) PMID 25466344

  10. Asthma 2014: from monoclonals to the microbiome.

    The lancet. Respiratory medicine 2(12):956 (2014) PMID 25466344

  11. MicroRNA: Potential biomarkers and therapeutic targets for allergic asthma?

    Annals of Medicine 46(8):633 (2014) PMID 25307360

    Abstract MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and differentiation). ...
  12. Production and differentiation of myeloid cells driven by proinflammatory cytokines in response to acute pneumovirus infection in mice.

    Journal of Immunology 193(8):4072 (2014) PMID 25200951 PMCID PMC4185243

    Respiratory virus infections are often pathogenic, driving severe inflammatory responses. Most research has focused on localized effects of virus infection and inflammation. However, infection can induce broad-reaching, systemic changes that are only beginning to be characterized. In this study,...
  13. Production and differentiation of myeloid cells driven by proinflammatory cytokines in response to acute pneumovirus infection in mice.

    Journal of Immunology 193(8):4072 (2014) PMID 25200951 PMCID PMC4185243

    Respiratory virus infections are often pathogenic, driving severe inflammatory responses. Most research has focused on localized effects of virus infection and inflammation. However, infection can induce broad-reaching, systemic changes that are only beginning to be characterized. In this study,...
  14. Dopamine does not appear to affect mental rotation in Parkinson's disease.

    Journal of movement disorders 7(2):77 (2014) PMID 25360231 PMCID PMC4213535

    Patients with Parkinson's disease (PD) often have deficits with mental rotation (MR). The neuropathological factors underlying these deficits, however, remain to be elucidated. One hypothesis suggests that dopamine depletion in nigro-striatal systems adversely influences MR. Another hypothesis s...
  15. Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations.

    Journal of Leukocyte Biology 96(3):391 (2014) PMID 24904000 PMCID PMC4138203

    Exacerbations of asthma are most commonly triggered by viral infections, which amplify allergic inflammation. Cytokines released by virus-infected AECs may be important in driving this response. This review focuses on accumulating evidence in support of a role for epithelial cytokines, including...
  16. Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations.

    Journal of Leukocyte Biology 96(3):391 (2014) PMID 24904000 PMCID PMC4138203

    Exacerbations of asthma are most commonly triggered by viral infections, which amplify allergic inflammation. Cytokines released by virus-infected AECs may be important in driving this response. This review focuses on accumulating evidence in support of a role for epithelial cytokines, including...
  17. Tumor necrosis factor-related apoptosis-inducing ligand regulates hallmark features of airways remodeling in allergic airways disease.

    American Journal of Respiratory Cell and Molecu... 51(1):86 (2014) PMID 24484417

    Allergic asthma is a complex disease characterized by acute inflammation of the airways that over time leads to the development of significant structural changes termed remodeling. TNF-related apoptosis-inducing ligand (TRAIL) has an important regulatory role in acute allergic airways inflammati...
  18. Administration of exogenous melatonin increases spreading activation in lexical memory networks.

    Human Psychopharmacology: Clinical and Experime... 29(4):397 (2014) PMID 25163444

    Several studies have examined the effect of exogenous melatonin on memory and cognitive functioning. Many of these investigations have reported improvement in recall and recognition as well as performance on various other indices of neuropsychological functioning. However, there have been no inv...
  19. Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis.

    Journal of Biological Chemistry 289(26):18214 (2014) PMID 24821729 PMCID PMC4140286

    Protease serine member S31 (Prss31)/transmembrane tryptase/tryptase-γ is a mast cell (MC)-restricted protease of unknown function that is retained on the outer leaflet of the plasma membrane when MCs are activated. We determined the nucleotide sequences of the Prss31 gene in different mouse stra...
  20. Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A.

    Journal of Allergy and Clinical Immunology 133(6):1720 (2014) PMID 24388637

    β-Agonists are used for relief and control of asthma symptoms by reversing bronchoconstriction. They might also have anti-inflammatory properties, but the underpinning mechanisms remain poorly understood. Recently, a direct interaction between formoterol and protein phosphatase 2A (PP2A) has bee...