1. A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.

    Genes & Development 28(16):1758 (2014) PMID 25128496 PMCID PMC4197961

    The dynamic reversible methylation of lysine residues on histone proteins is central to chromatin biology. Key components are demethylase enzymes, which remove methyl moieties from lysine residues. KDM2A, a member of the Jumonji C domain-containing histone lysine demethylase family, specifically...
  2. A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.

    Genes & Development 28(16):1758 (2014) PMID 25128496 PMCID PMC4197961

    The dynamic reversible methylation of lysine residues on histone proteins is central to chromatin biology. Key components are demethylase enzymes, which remove methyl moieties from lysine residues. KDM2A, a member of the Jumonji C domain-containing histone lysine demethylase family, specifically...
  3. A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.

    Genes & Development 28(16):1758 (2014) PMID 25128496 PMCID PMC4197961

    The dynamic reversible methylation of lysine residues on histone proteins is central to chromatin biology. Key components are demethylase enzymes, which remove methyl moieties from lysine residues. KDM2A, a member of the Jumonji C domain-containing histone lysine demethylase family, specifically...
  4. A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.

    Genes & Development 28(16):1758 (2014) PMID 25128496 PMCID PMC4197961

    The dynamic reversible methylation of lysine residues on histone proteins is central to chromatin biology. Key components are demethylase enzymes, which remove methyl moieties from lysine residues. KDM2A, a member of the Jumonji C domain-containing histone lysine demethylase family, specifically...
  5. A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.

    Genes & Development 28(16):1758 (2014) PMID 25128496 PMCID PMC4197961

    The dynamic reversible methylation of lysine residues on histone proteins is central to chromatin biology. Key components are demethylase enzymes, which remove methyl moieties from lysine residues. KDM2A, a member of the Jumonji C domain-containing histone lysine demethylase family, specifically...
  6. A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation.

    Molecular Cell 50(3):444 (2013) PMID 23583077 PMCID PMC3660009

    Lysine methylation of histone proteins regulates chromatin dynamics and plays important roles in diverse physiological and pathological processes. However, beyond histone proteins, the proteome-wide extent of lysine methylation remains largely unknown. We have engineered the naturally occurring ...
  7. A General Molecular Affinity Strategy for Global Detection and Proteomic Analysis of Lysine Methylation

    Molecular Cell 50(3):444 (2013)

    Lysine methylation of histone proteins regulates chromatin dynamics and plays important roles in diverse physiological and pathological processes. However, beyond histone proteins, the proteome-wide extent of lysine methylation remains largely unknown. We have engineered the naturally ...
  8. The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome.

    Nature 484(7392):115 (2012) PMID 22398447 PMCID PMC3321094

    The recognition of distinctly modified histones by specialized 'effector' proteins constitutes a key mechanism for transducing molecular events at chromatin to biological outcomes. Effector proteins influence DNA-templated processes, including transcription, DNA recombination and DNA repair; how...
  9. The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome.

    Nature 484(7392):115 (2012) PMID 22398447 PMCID PMC3321094

    The recognition of distinctly modified histones by specialized 'effector' proteins constitutes a key mechanism for transducing molecular events at chromatin to biological outcomes. Effector proteins influence DNA-templated processes, including transcription, DNA recombination and DNA repair; how...
  10. Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling.

    Nature Medicine 18(1):111 (2012) PMID 22138751 PMCID PMC3272332

    Mechanisms of epithelial cell renewal remain poorly understood in the mammalian kidney, particularly in the glomerulus, a site of cellular damage in chronic kidney disease. Within the glomerulus, podocytes--differentiated epithelial cells crucial for filtration--are thought to lack substantial c...
  11. Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling.

    Nature Medicine 18(1):111 (2012) PMID 22138751 PMCID PMC3272332

    Mechanisms of epithelial cell renewal remain poorly understood in the mammalian kidney, particularly in the glomerulus, a site of cellular damage in chronic kidney disease. Within the glomerulus, podocytes--differentiated epithelial cells crucial for filtration--are thought to lack substantial c...
  12. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.

    Molecular Cell 44(4):609 (2011) PMID 22099308 PMCID PMC3222870

    The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in understanding how this...
  13. NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming

    Molecular Cell 44(4):609 (2011)

    The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in understandin...
  14. NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming

    Molecular Cell 44(4):609 (2011) PMID 22099308 PMCID PMC3222870

    The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in understanding how...
  15. NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming

    Molecular Cell 44(4):609 (2011) PMID 22099308 PMCID PMC3222870

    The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in understanding how...
  16. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.

    Nature Immunology 12(1):29 (2011) PMID 21131967 PMCID PMC3074206

    Signaling via the methylation of lysine residues in proteins has been linked to diverse biological and disease processes, yet the catalytic activity and substrate specificity of many human protein lysine methyltransferases (PKMTs) are unknown. We screened over 40 candidate PKMTs and identified S...
  17. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.

    Nature Immunology 12(1):29 (2011) PMID 21131967 PMCID PMC3074206

    Signaling via the methylation of lysine residues in proteins has been linked to diverse biological and disease processes, yet the catalytic activity and substrate specificity of many human protein lysine methyltransferases (PKMTs) are unknown. We screened over 40 candidate PKMTs and identified S...
  18. The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate.

    Journal of Biological Chemistry 284(49):34283 (2009) PMID 19808676 PMCID PMC2797197

    The NSD (nuclear receptor SET domain-containing) family of histone lysine methyltransferases is a critical participant in chromatin integrity as evidenced by the number of human diseases associated with the aberrant expression of its family members. Yet, the specific targets of these enzymes are...
  19. The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate.

    Journal of Biological Chemistry 284(49):34283 (2009) PMID 19808676 PMCID PMC2797197

    The NSD (nuclear receptor SET domain-containing) family of histone lysine methyltransferases is a critical participant in chromatin integrity as evidenced by the number of human diseases associated with the aberrant expression of its family members. Yet, the specific targets of these enzymes are...
  20. Telomerase modulates Wnt signalling by association with target gene chromatin.

    Nature 460(7251):66 (2009) PMID 19571879 PMCID PMC4349391

    Stem cells are controlled, in part, by genetic pathways frequently dysregulated during human tumorigenesis. Either stimulation of Wnt/beta-catenin signalling or overexpression of telomerase is sufficient to activate quiescent epidermal stem cells in vivo, although the mechanisms by which telomer...