Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice.
Life Sciences 143:65 (2015)
Cancer-related fatigue (CRF) is often accompanied by depressed mood, both of which reduce functional status and quality of life. Research suggests that increased expression of pro-inflammatory cytokines is associated with skeletal muscle wasting and depressive- and fatigue-like behaviors in rode...
Nucleotide and protein sequences for dog masticatory tropomyosin identify a novel Tpm4 gene product.
Journal of Muscle Research and Cell Motility 36(4-5):339 (2015)
Jaw-closing muscles of several vertebrate species, including members of Carnivora, express a unique, "masticatory", isoform of myosin heavy chain, along with isoforms of other myofibrillar proteins that are not expressed in most other muscles. It is generally believed that the complement of myof...
Metalloproteinase expression is altered in cardiac and skeletal muscle in cancer cachexia.
American Journal of Physiology - Heart and Circ... 309(4):H685 (2015)
Cardiac and skeletal muscle dysfunction is a recognized effect of cancer-induced cachexia, with alterations in heart function leading to heart failure and negatively impacting patient morbidity. Cachexia is a complex and multifaceted disease state with several potential contributors to cardiac a...
Losartan treatment attenuates tumor-induced myocardial dysfunction.
Journal of Molecular and Cellular Cardiology 85:37 (2015)
Fatigue and muscle wasting are common symptoms experienced by cancer patients. Data from animal models demonstrate that angiotensin is involved in tumor-induced muscle wasting, and that tumor growth can independently affect myocardial function, which could contribute to fatigue in cancer patient...
Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue.
Physiology & Behavior 140:230 (2015)
Cancer patients frequently suffer from fatigue, a complex syndrome associated with tiredness and depressed mood. Cancer-related fatigue (CRF) can be present at the time of diagnosis, escalates during treatment, and can persist for years after treatment. CRF negatively influences quality of life,...
Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function.
Brain, Behavior, and Immunity 43:76 (2015)
Cancer patients frequently suffer from fatigue, a complex syndrome associated with loss of muscle mass, weakness, and depressed mood. Cancer-related fatigue (CRF) can be present at the time of diagnosis, during treatment, and persists for years after treatment. CRF negatively influences quality ...
Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy.
Frontiers in Physiology 6:242 (2015)
The physiological consequences of aberrant Ca(2+) binding and exchange with cardiac myofilaments are not clearly understood. In order to examine the effect of decreasing Ca(2+) sensitivity of cTnC on cardiac function, we generated knock-in mice carrying a D73N mutation (not known to be associate...
Electrophoretic separation of reptilian skeletal and cardiac muscle myosin heavy chain isoforms: dependence on gel format.
Electrophoresis 35(18):2615 (2014)
This report provides a comparison of multiple gel formats to study myosin heavy chain (MHC) isoforms that are expressed in reptilian skeletal and cardiac muscles of five turtle species, water monitor, and prehensile tailed skink. Three gel formats were tested. The results identify one format tha...
Sex differences in myosin heavy chain isoforms of human failing and nonfailing atria.
American Journal of Physiology - Heart and Circ... 307(3):H265 (2014)
Mammalian hearts express two myosin heavy chain (MHC) isoforms, which drive contractions with different kinetics and power-generating ability. The expression of the isoform that is associated with more rapid contraction kinetics and greater power output, MHC-α, is downregulated, with a concurren...
Complex tropomyosin and troponin T isoform expression patterns in orbital and global fibers of adult dog and rat extraocular muscles.
Journal of Muscle Research and Cell Motility 34(3-4):211 (2013)
We reported marked differences in the myosin heavy and light chain (MHC and MLC) isoform composition of fast and slow fibers between the global and orbital layers of dog extraocular muscles. Many dog extraocular fibers, especially orbital fibers, have MHC and MLC isoform patterns that are distin...
Very low force-generating ability and unusually high temperature dependency in hummingbird flight muscle fibers.
Journal of Experimental Biology 216(Pt 12):2247 (2013)
Hummingbird flight muscle is estimated to have among the highest mass-specific power output among vertebrates, based on aerodynamic models. However, little is known about the fundamental contractile properties of their remarkable flight muscles. We hypothesized that hummingbird pectoralis fibers...
Regulation of contractile proteins and protein translational signaling in disused muscle.
Cellular Physiology and Biochemistry 30(5):1202 (2012)
Muscle disuse can lead to muscle atrophy and impaired skeletal muscle function. How skeletal muscle modulates protein translational signaling in response to prolonged muscle disuse is not well understood. Using the hindlimb unloading (HU) model of muscle atrophy we examined how hindlimb unweight...
Patterns of tropomyosin and troponin-T isoform expression in jaw-closing muscles of mammals and reptiles that express masticatory myosin.
Journal of Experimental Biology 214(Pt 7):1077 (2011)
We recently reported that masticatory ('superfast') myosin is expressed in jaw-closing muscles of some rodent species. Most mammalian limb muscle fibers express tropomyosin-β (Tm-β), along with fast-type or slow-type tropomyosin-β (Tm-β), but jaw-closing muscle fibers in members of Carnivora exp...
Cardiac alterations in cancer-induced cachexia in mice.
International Journal of Oncology 37(2):347 (2010)
Cachexia is a common syndrome in advanced cancer patients and causes up to 22% of cancer-related deaths. It remains elusive whether cancer cachexia causes heart failure. We investigated the effect of cancer cachexia on heart function and cardiac muscle structure in a mouse model. Male CD2F1 mice...
The myosin light chain 1 isoform associated with masticatory myosin heavy chain in mammals and reptiles is embryonic/atrial MLC1.
Journal of Experimental Biology 213(Pt 10):1633 (2010)
We recently reported that masticatory myosin heavy chain (MHC-M) is expressed as the exclusive or predominant MHC isoform in masseter and temporalis muscles of several rodent species, contrary to the prevailing dogma that rodents express almost exclusively MHC isoforms that are typically found i...
Challenges in skeletal muscle physiology.
Frontiers in Physiology 1:151 (2010)
Redox modulation of global phosphatase activity and protein phosphorylation in intact skeletal muscle.
Journal of Physiology 587(Pt 23):5767 (2009)
Skeletal muscles produce transient reactive oxygen species (ROS) in response to intense stimulation, disuse atrophy, heat stress, hypoxia, osmotic stress, stretch and cell receptor activation. The physiological significance is not well understood. Protein phosphatases (PPases) are known to be hi...
Masticatory (;superfast') myosin heavy chain and embryonic/atrial myosin light chain 1 in rodent jaw-closing muscles.
Journal of Experimental Biology 212(Pt 16):2511 (2009)
Masticatory myosin is widely expressed among several vertebrate classes. Generally, the expression of masticatory myosin has been associated with high bite force for a carnivorous feeding style (including capturing/restraining live prey), breaking down tough plant material and defensive biting i...
Myosin isoform expression in dog rectus muscles: patterns in global and orbital layers and among single fibers.
Investigative Ophthalmology & Visual Science 50(1):157 (2009)
To quantitate the distribution of myosin heavy chain (MyHC) isoforms along the global and orbital layers of dog rectus muscles and determine MyHC and myosin light chain (MLC) isoform patterns among single fibers from both layers.
Serial samples of both layers of rectus muscles were prepared for ...
Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility.
PNAS 104(45):17867 (2007)
Sarcolipin is a novel regulator of cardiac sarcoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) and is expressed abundantly in atria. In this study we investigated the physiological significance of sarcolipin in the heart by generating a mouse model deficient for sarcolipin. The sarcolipin-null mice ...