Carnosine metabolism in diabetes is altered by reactive metabolites.
Amino Acids 47(11):2367 (2015)
Carnosinase 1 (CN1) contributes to diabetic nephropathy by cleaving histidine-dipeptides which scavenge reactive oxygen and carbonyl species and increase nitric oxide (NO) production. In diabetic mice renal CN1 activity is increased, the regulatory mechanisms are unknown. We therefore analysed t...
Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus.
BMC Endocrine Disorders 14:33 (2014)
Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type 1 and 2 diabetes.
Three hundred and ninety-eight consecutive diabetic patients from a s...
RAGE controls activation and anti-inflammatory signalling of protein C.
PLoS ONE 9(2):e89422 (2014)
The receptor for advanced glycation endproducts, RAGE, is a multiligand receptor and NF-κB activator leading to perpetuation of inflammation. We investigated whether and how RAGE is involved in mediation of anti-inflammatory properties of protein C.
We analyzed the effect of protein C on leukocy...
Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban.
Stroke 44(3):771 (2013)
Rivaroxaban has recently been approved for stroke prevention in atrial fibrillation. However, lack of an effective antidote represents a major concern in the event of intracerebral hemorrhage (ICH). The aims of the present study were to establish a murine model of ICH associated with rivaroxaban...
The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition.
Thrombosis and Haemostasis 108(6):1141 (2012)
Coagulation and complement regulators belong to two interactive systems constituting emerging mechanisms of diabetic nephropathy. Thrombomodulin (TM) regulates both coagulation and complement activation, in part through discrete domains. TM's lectin like domain dampens complement activation, whi...
Kyphoplasty in patients with multiple myeloma a retrospective comparative pilot study.
Journal of Surgical Oncology 105(7):679 (2012)
This retrospective study of 73 myeloma patients with painful vertebral lesions compares clinical and radiomorphological outcomes up to 2 years after additional kyphoplasty, radiation therapy or systemic treatment only.
We assessed pain, disability and radiomorphological parameters by visual anal...
Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation.
Journal of Biological Chemistry 287(8):5400 (2012)
We recently demonstrated that the bZip transcription factor nuclear factor erythroid-derived 2 (Nfe2) represses protein acetylation and expression of the transcription factor glial cell missing 1 (Gcm1) in trophoblast cells, preventing excess syncytiotrophoblast formation and permitting normal p...
Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.
Aging Cell 9(3):420 (2010)
Deletions in mitochondrial DNA (mtDNA) accumulate during aging. Expression of the Caenorhabditis elegans apurinic/apyrimidinic endonuclease 1 (APE1) ortholog exo-3, involved in DNA repair, is reduced by 45% (P < 0.05) during aging of C. elegans. Suppression of exo-3 by treatment with RNAi result...
[Acceptance- and mindfulness-based group intervention in advanced type 2 diabetes patients: therapeutic concept and practical experiences].
PPmP - Psychotherapie Â· Psychosomatik Â· Mediz... 60(5):185 (2010)
Patients with type 2 diabetes mellitus and early diabetic nephropathy have a poor disease-related prognosis; furthermore these patients are often also mentally stressed. We investigated an acceptance- and mindfulness-based group intervention for these patients in addition to regular medical ther...
Three-year outcomes after kyphoplasty in patients with osteoporosis with painful vertebral fractures.
Journal of Vascular and Interventional Radiology 21(5):701 (2010)
Kyphoplasty immediately improves pain and mobility in patients with painful osteoporotic vertebral fractures, but long-term clinical outcomes are still unclear. This controlled trial evaluates pain, mobility and fracture incidence 3 years after kyphoplasty.
Kyphoplasty was performed in 40 patien...
A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival.
Embo Molecular Medicine 2(2):51 (2010)
Deficiency of the mitochondrial enzyme 2-methyl-3-hydroxybutyryl-CoA dehydrogenase involved in isoleucine metabolism causes an organic aciduria with atypical neurodegenerative course. The disease-causing gene is HSD17B10 and encodes 17beta-hydroxysteroid dehydrogenase type 10 (HSD10), a protein ...
Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation.
BMC Genomics 11:537 (2010)
In the past, molecular mechanisms that drive the initiation of an inflammatory response have been studied intensively. However, corresponding mechanisms that sustain the expression of inflammatory response genes and hence contribute to the establishment of chronic disorders remain poorly underst...
Direct effects of osteoprotegerin on human bone cell metabolism.
Biochemical and Biophysical Research Communicat... 389(3):550 (2009)
Osteoprotegerin (OPG) affects bone metabolism by intercepting the RANK-RANKL interaction which prevents osteoclastic differentiation and consequently reduces bone resorption. Different bone phenotypes of mice overexpressing OPG and of mice with knockdown of receptor activator of NF-kappaB (RANK)...
C. elegans as model for the study of high glucose- mediated life span reduction.
Diabetes 58(11):2450 (2009)
Establishing Caenorhabditis elegans as a model for glucose toxicity-mediated life span reduction.
C. elegans were maintained to achieve glucose concentrations resembling the hyperglycemic conditions in diabetic patients. The effects of high glucose on life span, glyoxalase-1 activity, advanced g...
The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation.
Stroke 40(8):2849 (2009)
Therapeutic modification of the postischemic immune processes is a key target of current experimental stroke research. For successful translation into the clinical setting, experimental studies must account for the impact of different strokes on the immune system including susceptibility to infe...
Clinical impact of two different intraoperative parathyroid hormone assays in primary and renal hyperparathyroidism.
European Journal of Endocrinology 160(2):275 (2009)
Intraoperative parathyroid hormone (PTH) monitoring predicts successful surgery for primary hyperparathyroidism (pHPT). In renal HPT, intraoperative PTH assays can define whether parathyroid resection is adequate.
Intraoperative PTH was measured with two different immunometric assays (Immulite T...
Direct effects of osteoprotegerin on human bone cell metabolism
Biochemical and Biophysical Research Communicat... 389(3):550 (2009)
Osteoprotegerin (OPG) affects bone metabolism by intercepting the RANK–RANKL interaction which prevents osteoclastic differentiation and consequently reduces bone resorption. Different bone phenotypes of mice overexpressing OPG and of mice with knockdown of receptor activator o...
Calcium-phosphate and polymethylmethacrylate cement in long-term outcome after kyphoplasty of painful osteoporotic vertebral fractures.
Spine 33(11):1284 (2008)
A comparative prospective trial evaluating 3-year outcome.
To compare clinical and morphologic outcomes as well as follow-up fractures after kyphoplasty of painful osteoporotic vertebral fractures with calcium-phosphate (CaP) cement (group 1) and with polymethylmethacrylate (PMMA)-cement (group ...
Effect of parathyroidectomy on quality of life and neuropsychological symptoms in primary hyperparathyroidism.
World Journal of Surgery 31(6):1202 (2007)
Neuropsychological symptoms are found in a certain number of patients with primary hyperparathyroidism (PHPT). Preoperative and postoperative quality of life, anxiety, and depression are measured to analyze the impact of parathyroidectomy on these symptoms. In this prospective study, 66 patients...
Activation of the RAGE pathway: a general mechanism in the pathogenesis of polyneuropathies?
Neurological Research 29(1):103 (2007)
Binding of ligands to the receptor for advanced glycation end products (RAGE) results in activation of the transcription factor NF-kappaB and subsequent expression of NF-kappaB regulated cytokines and is a possible pathomechanism in diabetic and in vasculitic polyneuropathies (PNP). We wanted to...