1. Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus.

    BMC Endocrine Disorders 14:33 (2014) PMID 24721668 PMCID PMC4021186

    Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type 1 and 2 diabetes. Three hundred and ninety-eight consecutive diabetic patients from a s...
  2. RAGE controls activation and anti-inflammatory signalling of protein C.

    PLoS ONE 9(2):e89422 (2014) PMID 24586767 PMCID PMC3933550

    The receptor for advanced glycation endproducts, RAGE, is a multiligand receptor and NF-κB activator leading to perpetuation of inflammation. We investigated whether and how RAGE is involved in mediation of anti-inflammatory properties of protein C. We analyzed the effect of protein C on leukocy...
  3. RAGE controls activation and anti-inflammatory signalling of protein C.

    PLoS ONE 9(2):e89422 (2014) PMID 24586767 PMCID PMC3933550

    The receptor for advanced glycation endproducts, RAGE, is a multiligand receptor and NF-κB activator leading to perpetuation of inflammation. We investigated whether and how RAGE is involved in mediation of anti-inflammatory properties of protein C. We analyzed the effect of protein C on leukocy...
  4. Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus.

    BMC Endocrine Disorders 14:33 (2014) PMID 24721668 PMCID PMC4021186

    Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type 1 and 2 diabetes. Three hundred and ninety-eight consecutive diabetic patients from a s...
  5. Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus.

    BMC Endocrine Disorders 14:33 (2014) PMID 24721668 PMCID PMC4021186

    Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type 1 and 2 diabetes. Three hundred and ninety-eight consecutive diabetic patients from a s...
  6. RAGE controls activation and anti-inflammatory signalling of protein C.

    PLoS ONE 9(2):e89422 (2014) PMID 24586767 PMCID PMC3933550

    The receptor for advanced glycation endproducts, RAGE, is a multiligand receptor and NF-κB activator leading to perpetuation of inflammation. We investigated whether and how RAGE is involved in mediation of anti-inflammatory properties of protein C. We analyzed the effect of protein C on leukocy...
  7. Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban.

    Stroke 44(3):771 (2013) PMID 23339956

    Rivaroxaban has recently been approved for stroke prevention in atrial fibrillation. However, lack of an effective antidote represents a major concern in the event of intracerebral hemorrhage (ICH). The aims of the present study were to establish a murine model of ICH associated with rivaroxaban...
  8. Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban.

    Stroke 44(3):771 (2013) PMID 23339956

    Rivaroxaban has recently been approved for stroke prevention in atrial fibrillation. However, lack of an effective antidote represents a major concern in the event of intracerebral hemorrhage (ICH). The aims of the present study were to establish a murine model of ICH associated with rivaroxaban...
  9. The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition.

    Thrombosis and Haemostasis 108(6):1141 (2012) PMID 23014597

    Coagulation and complement regulators belong to two interactive systems constituting emerging mechanisms of diabetic nephropathy. Thrombomodulin (TM) regulates both coagulation and complement activation, in part through discrete domains. TM's lectin like domain dampens complement activation, whi...
  10. The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition.

    Thrombosis and Haemostasis 108(6):1141 (2012) PMID 23014597

    Coagulation and complement regulators belong to two interactive systems constituting emerging mechanisms of diabetic nephropathy. Thrombomodulin (TM) regulates both coagulation and complement activation, in part through discrete domains. TM's lectin like domain dampens complement activation, whi...
  11. Kyphoplasty in patients with multiple myeloma a retrospective comparative pilot study.

    Journal of Surgical Oncology 105(7):679 (2012) PMID 21960293

    This retrospective study of 73 myeloma patients with painful vertebral lesions compares clinical and radiomorphological outcomes up to 2 years after additional kyphoplasty, radiation therapy or systemic treatment only. We assessed pain, disability and radiomorphological parameters by visual anal...
  12. Kyphoplasty in patients with multiple myeloma a retrospective comparative pilot study.

    Journal of Surgical Oncology 105(7):679 (2012) PMID 21960293

    This retrospective study of 73 myeloma patients with painful vertebral lesions compares clinical and radiomorphological outcomes up to 2 years after additional kyphoplasty, radiation therapy or systemic treatment only. We assessed pain, disability and radiomorphological parameters by visual anal...
  13. Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation.

    Journal of Biological Chemistry 287(8):5400 (2012) PMID 22174410 PMCID PMC3285319

    We recently demonstrated that the bZip transcription factor nuclear factor erythroid-derived 2 (Nfe2) represses protein acetylation and expression of the transcription factor glial cell missing 1 (Gcm1) in trophoblast cells, preventing excess syncytiotrophoblast formation and permitting normal p...
  14. Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation.

    Journal of Biological Chemistry 287(8):5400 (2012) PMID 22174410 PMCID PMC3285319

    We recently demonstrated that the bZip transcription factor nuclear factor erythroid-derived 2 (Nfe2) represses protein acetylation and expression of the transcription factor glial cell missing 1 (Gcm1) in trophoblast cells, preventing excess syncytiotrophoblast formation and permitting normal p...
  15. Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.

    Aging Cell 9(3):420 (2010) PMID 20346071

    Deletions in mitochondrial DNA (mtDNA) accumulate during aging. Expression of the Caenorhabditis elegans apurinic/apyrimidinic endonuclease 1 (APE1) ortholog exo-3, involved in DNA repair, is reduced by 45% (P < 0.05) during aging of C. elegans. Suppression of exo-3 by treatment with RNAi result...
  16. Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.

    Aging Cell 9(3):420 (2010) PMID 20346071

    Deletions in mitochondrial DNA (mtDNA) accumulate during aging. Expression of the Caenorhabditis elegans apurinic/apyrimidinic endonuclease 1 (APE1) ortholog exo-3, involved in DNA repair, is reduced by 45% (P < 0.05) during aging of C. elegans. Suppression of exo-3 by treatment with RNAi result...
  17. [Acceptance- and mindfulness-based group intervention in advanced type 2 diabetes patients: therapeutic concept and practical experiences].

    PPmP - Psychotherapie · Psychosomatik · Mediz... 60(5):185 (2010) PMID 20480441

    Patients with type 2 diabetes mellitus and early diabetic nephropathy have a poor disease-related prognosis; furthermore these patients are often also mentally stressed. We investigated an acceptance- and mindfulness-based group intervention for these patients in addition to regular medical ther...
  18. [Acceptance- and mindfulness-based group intervention in advanced type 2 diabetes patients: therapeutic concept and practical experiences].

    PPmP - Psychotherapie · Psychosomatik · Mediz... 60(5):185 (2010) PMID 20480441

    Patients with type 2 diabetes mellitus and early diabetic nephropathy have a poor disease-related prognosis; furthermore these patients are often also mentally stressed. We investigated an acceptance- and mindfulness-based group intervention for these patients in addition to regular medical ther...
  19. Three-year outcomes after kyphoplasty in patients with osteoporosis with painful vertebral fractures.

    Journal of Vascular and Interventional Radiology 21(5):701 (2010) PMID 20304677

    Kyphoplasty immediately improves pain and mobility in patients with painful osteoporotic vertebral fractures, but long-term clinical outcomes are still unclear. This controlled trial evaluates pain, mobility and fracture incidence 3 years after kyphoplasty. Kyphoplasty was performed in 40 patien...
  20. A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival.

    Embo Molecular Medicine 2(2):51 (2010) PMID 20077426 PMCID PMC3377269

    Deficiency of the mitochondrial enzyme 2-methyl-3-hydroxybutyryl-CoA dehydrogenase involved in isoleucine metabolism causes an organic aciduria with atypical neurodegenerative course. The disease-causing gene is HSD17B10 and encodes 17beta-hydroxysteroid dehydrogenase type 10 (HSD10), a protein ...