1. IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression.

    Journal of Immunology 186(6):3666 (2011) PMID 21300820

    Cystatin C (CstC) is a cysteine protease inhibitor of major clinical importance. Low concentration of serum CstC is linked to atherosclerosis. CstC can prevent formation of amyloid β associated with Alzheimer's disease and can itself form toxic aggregates. CstC regulates NO secretion by macropha...
  2. IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression.

    Journal of Immunology 186(6):3666 (2011) PMID 21300820

    Cystatin C (CstC) is a cysteine protease inhibitor of major clinical importance. Low concentration of serum CstC is linked to atherosclerosis. CstC can prevent formation of amyloid β associated with Alzheimer's disease and can itself form toxic aggregates. CstC regulates NO secretion by macropha...
  3. Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells.

    Nature Immunology 9(11):1244 (2008) PMID 18849989

    The importance of conventional dendritic cells (cDCs) in the processing and presentation of antigen is well established, but the contribution of plasmacytoid dendritic cells (pDCs) to these processes, and hence to T cell immunity, remains unclear. Here we showed that unlike cDCs, pDCs continued ...
  4. Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells.

    Nature Immunology 9(11):1244 (2008) PMID 18849989

    The importance of conventional dendritic cells (cDCs) in the processing and presentation of antigen is well established, but the contribution of plasmacytoid dendritic cells (pDCs) to these processes, and hence to T cell immunity, remains unclear. Here we showed that unlike cDCs, pDCs continued ...
  5. Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens.

    PNAS 104(45):17753 (2007) PMID 17978177 PMCID PMC2077019

    When dendritic cells (DCs) encounter signals associated with infection or inflammation, they become activated and undergo maturation. Mature DCs are very efficient at presenting antigens captured in association with their activating signal but fail to present subsequently encountered antigens, a...
  6. Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens.

    PNAS 104(45):17753 (2007) PMID 17978177 PMCID PMC2077019

    When dendritic cells (DCs) encounter signals associated with infection or inflammation, they become activated and undergo maturation. Mature DCs are very efficient at presenting antigens captured in association with their activating signal but fail to present subsequently encountered antigens, a...
  7. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo.

    Nature Reviews: Immunology 7(7):543 (2007) PMID 17589544

    Dendritic cells (DCs) comprise several subsets, and their roles in the presentation of antigens derived from pathogens, vaccines and self tissues are now beginning to be elucidated. Differences in location, life cycle and intrinsic abilities to capture, process and present antigens on their MHC ...
  8. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo.

    Nature Reviews: Immunology 7(7):543 (2007) PMID 17589544

    Dendritic cells (DCs) comprise several subsets, and their roles in the presentation of antigens derived from pathogens, vaccines and self tissues are now beginning to be elucidated. Differences in location, life cycle and intrinsic abilities to capture, process and present antigens on their MHC ...
  9. The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture.

    PNAS 103(28):10729 (2006) PMID 16807294 PMCID PMC1502299

    Mouse spleens contain three populations of conventional (CD11c(high)) dendritic cells (DCs) that play distinct functions. The CD8(+) DC are unique in that they can present exogenous antigens on their MHC class I molecules, a process known as cross-presentation. It is unclear whether this special...
  10. The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture.

    PNAS 103(28):10729 (2006) PMID 16807294 PMCID PMC1502299

    Mouse spleens contain three populations of conventional (CD11c(high)) dendritic cells (DCs) that play distinct functions. The CD8(+) DC are unique in that they can present exogenous antigens on their MHC class I molecules, a process known as cross-presentation. It is unclear whether this special...
  11. Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells.

    Journal of Immunology 177(1):372 (2006) PMID 16785533

    A normalized subtracted gene expression library was generated from freshly isolated mouse dendritic cells (DC) of all subtypes, then used to construct cDNA microarrays. The gene expression profiles of the three splenic conventional DC (cDC) subsets were compared by microarray hybridization and t...
  12. Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells.

    Journal of Immunology 177(1):372 (2006) PMID 16785533

    A normalized subtracted gene expression library was generated from freshly isolated mouse dendritic cells (DC) of all subtypes, then used to construct cDNA microarrays. The gene expression profiles of the three splenic conventional DC (cDC) subsets were compared by microarray hybridization and t...
  13. Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells.

    Journal of Immunology 175(9):5940 (2005) PMID 16237087

    Dendritic cells (DC) initiate immunity and maintain tolerance. Although in vitro-generated DC, usually derived from peripheral blood monocytes (MO-DC), serve as prototype DC to analyze the biology and biochemistry of DC, phenotypically distinct primary types of DC, including CD1c-DC, are present...
  14. Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells.

    Journal of Immunology 175(9):5940 (2005) PMID 16237087

    Dendritic cells (DC) initiate immunity and maintain tolerance. Although in vitro-generated DC, usually derived from peripheral blood monocytes (MO-DC), serve as prototype DC to analyze the biology and biochemistry of DC, phenotypically distinct primary types of DC, including CD1c-DC, are present...
  15. Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces.

    Immunological Reviews 207:191 (2005) PMID 16181337

    The antigen capturing and presenting abilities of dendritic cells (DCs) are developmentally regulated in a process known as maturation. During maturation, DCs increase several fold their surface expression of major histocompatibility complex class II (MHC II) molecules. This increase is accompan...
  16. Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces.

    Immunological Reviews 207:191 (2005) PMID 16181337

    The antigen capturing and presenting abilities of dendritic cells (DCs) are developmentally regulated in a process known as maturation. During maturation, DCs increase several fold their surface expression of major histocompatibility complex class II (MHC II) molecules. This increase is accompan...
  17. Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures.

    Journal of Immunology 174(11):6592 (2005) PMID 15905497

    We demonstrate that functional and phenotypic equivalents of mouse splenic CD8(+) and CD8(-) conventional dendritic cell (cDC) subsets can be generated in vitro when bone marrow is cultured with fms-like tyrosine kinase 3 (flt3) ligand. In addition to CD45RA(high) plasmacytoid DC, two distinct C...
  18. Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures.

    Journal of Immunology 174(11):6592 (2005) PMID 15905497

    We demonstrate that functional and phenotypic equivalents of mouse splenic CD8(+) and CD8(-) conventional dendritic cell (cDC) subsets can be generated in vitro when bone marrow is cultured with fms-like tyrosine kinase 3 (flt3) ligand. In addition to CD45RA(high) plasmacytoid DC, two distinct C...
  19. Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis.

    Journal of Clinical Investigation 112(4):517 (2003) PMID 12925692 PMCID PMC171390

    Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in peripheral APCs have both been implicated in the last step of Ii degradation that gives rise to the class II-associate...
  20. Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis.

    Journal of Clinical Investigation 112(4):517 (2003) PMID 12925692 PMCID PMC171390

    Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in peripheral APCs have both been implicated in the last step of Ii degradation that gives rise to the class II-associate...