1. Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity.

    Stem Cells 33(7):2306 (2015) PMID 25919237 PMCID PMC4478223

    Neural activity is tightly coupled to energy consumption, particularly sugars such as glucose. However, we find that, unlike mature neurons and astrocytes, neural stem/progenitor cells (NSPCs) do not require glucose to sustain aerobic respiration. NSPCs within the adult subventricular zone (SVZ)...
  2. A functionalized, injectable hydrogel for localized drug delivery with tunable thermosensitivity: synthesis and characterization of physical and toxicological properties.

    Journal of Controlled Release 208:76 (2015) PMID 25747144

    Thermosensitive injectable hydrogels have been used for the delivery of pharmacological and cellular therapies in a variety of soft tissue applications. A promising class of synthetic, injectable hydrogels based upon oligo(ethylene glycol) methacrylate (OEGMA) monomers has been previously report...
  3. Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency.

    Biomaterials 54:87 (2015) PMID 25907042 PMCID PMC4409668

    There is currently no cure for neuron loss in the brain, which can occur due to traumatic injury or neurodegenerative disease. One proposed method to enhance brain neurogenesis is gene transfer to neural progenitor cells. In this work, a guanidine-based copolymer was synthesized and compared to ...
  4. Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve.

    Investigative Ophthalmology & Visual Science 56(3):1437 (2015) PMID 25655803 PMCID PMC4347310

    Decreased ATP correlates with intraocular pressure exposure in the optic nerves of mice with glaucoma. To understand what underlies this energy deficit, we examined mitochondria in the myelinated optic nerve axons of the DBA/2J mouse, a model of glaucoma secondary to iris pigment disease, and th...
  5. Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve.

    Investigative Ophthalmology & Visual Science 56(3):1437 (2015) PMID 25655803 PMCID PMC4347310

    Decreased ATP correlates with intraocular pressure exposure in the optic nerves of mice with glaucoma. To understand what underlies this energy deficit, we examined mitochondria in the myelinated optic nerve axons of the DBA/2J mouse, a model of glaucoma secondary to iris pigment disease, and th...
  6. Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion.

    Biomaterials 35(31):8895 (2014) PMID 25064804 PMCID PMC4136545

    Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local injection o...
  7. Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion.

    Biomaterials 35(31):8895 (2014) PMID 25064804 PMCID PMC4136545

    Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local injection o...
  8. Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency

    Biomaterials (2014)

    There is currently no cure for neuron loss in the brain, which can occur due to traumatic injury or neurodegenerative disease. One method proposed to enhance neurogenesis in the brain is gene transfer to neural progenitor cells. In this work, a guanidine-based copolymer was synthesized...
  9. Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion

    Biomaterials (2014)

    Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local i...
  10. Therapeutic intraspinal stimulation to generate activity and promote long-term recovery.

    Frontiers in Neuroscience 8:21 (2014) PMID 24578680 PMCID PMC3936503

    Neuroprosthetic approaches have tremendous potential for the treatment of injuries to the brain and spinal cord by inducing appropriate neural activity in otherwise disordered circuits. Substantial work has demonstrated that stimulation applied to both the central and peripheral nervous system l...
  11. Therapeutic intraspinal stimulation to generate activity and promote long-term recovery.

    Frontiers in Neuroscience 8:21 (2014) PMID 24578680 PMCID PMC3936503

    Neuroprosthetic approaches have tremendous potential for the treatment of injuries to the brain and spinal cord by inducing appropriate neural activity in otherwise disordered circuits. Substantial work has demonstrated that stimulation applied to both the central and peripheral nervous system l...
  12. Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma.

    Journal of Neuroscience 33(44):17444 (2013) PMID 24174678 PMCID PMC3812509

    Intraocular pressure (IOP) elevation is a principal risk factor for glaucoma. Using a microbead injection technique to chronically raise IOP for 15 or 30 d in mice, we identified the early changes in visual response properties of different types of retinal ganglion cells (RGCs) and correlated th...
  13. Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma.

    Journal of Neuroscience 33(44):17444 (2013) PMID 24174678 PMCID PMC3812509

    Intraocular pressure (IOP) elevation is a principal risk factor for glaucoma. Using a microbead injection technique to chronically raise IOP for 15 or 30 d in mice, we identified the early changes in visual response properties of different types of retinal ganglion cells (RGCs) and correlated th...
  14. The impact of age on oncogenic potential: tumor-initiating cells and the brain microenvironment.

    Aging Cell 12(5):733 (2013) PMID 23711239 PMCID PMC4199664

    Paradoxically, aging leads to both decreased regenerative capacity in the brain and an increased risk of tumorigenesis, particularly the most common adult-onset brain tumor, glioma. A shared factor contributing to both phenomena is thought to be age-related alterations in neural progenitor cells...
  15. Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model

    Experimental Neurology 248:491 (2013)

    Neural progenitor cells (NPCs) have shown modest potential and some side effects (e.g. allodynia) for treatment of spinal cord injury (SCI). In only a few cases, however, have NPCs shown promise at the chronic stage. Given the 1.275million people living with chronic paralysis, there is...
  16. Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model

    Experimental Neurology 248:491 (2013)

    Neural progenitor cells (NPCs) have shown modest potential and some side effects (e.g. allodynia) for treatment of spinal cord injury (SCI). In only a few cases, however, have NPCs shown promise at the chronic stage. Given the 1.275million people living with chronic paralysis, there is...
  17. The impact of age on oncogenic potential: tumor-initiating cells and the brain microenvironment.

    Aging Cell 12(5):733 (2013) PMID 23711239 PMCID PMC4199664

    Paradoxically, aging leads to both decreased regenerative capacity in the brain and an increased risk of tumorigenesis, particularly the most common adult-onset brain tumor, glioma. A shared factor contributing to both phenomena is thought to be age-related alterations in neural progenitor cells...
  18. Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model.

    Experimental Neurology 248:491 (2013) PMID 23891888 PMCID PMC4109283

    Neural progenitor cells (NPCs) have shown modest potential and some side effects (e.g. allodynia) for treatment of spinal cord injury (SCI). In only a few cases, however, have NPCs shown promise at the chronic stage. Given the 1.275 million people living with chronic paralysis, there is a signif...
  19. The impact of age on oncogenic potential: tumor-initiating cells and the brain microenvironment.

    Aging Cell 12(5):733 (2013) PMID 23711239 PMCID PMC4199664

    Paradoxically, aging leads to both decreased regenerative capacity in the brain and an increased risk of tumorigenesis, particularly the most common adult-onset brain tumor, glioma. A shared factor contributing to both phenomena is thought to be age-related alterations in neural progenitor cells...
  20. Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model

    Experimental Neurology 248:491 (2013)

    Neural progenitor cells (NPCs) have shown modest potential and some side effects (e.g. allodynia) for treatment of spinal cord injury (SCI). In only a few cases, however, have NPCs shown promise at the chronic stage. Given the 1.275million people living with chronic paralysis, there is...