1. Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection.

    Journal of Virology 89(9):4748 (2015) PMID 25673724 PMCID PMC4403498

    The B cell-activating factor (BAFF) is critical for B cell development and humoral immunity in mice and humans. While the role of BAFF in B cells has been widely described, its role in innate immunity remains unknown. Using BAFF receptor (BAFFR)-deficient mice, we characterized BAFFR-related inn...
  2. Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase.

    PNAS 112(17):5521 (2015) PMID 25870278 PMCID PMC4418919

    Urea cycle defects and acute or chronic liver failure are linked to systemic hyperammonemia and often result in cerebral dysfunction and encephalopathy. Although an important role of the liver in ammonia metabolism is widely accepted, the role of ammonia metabolizing pathways in the liver for ma...
  3. B7-h4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.

    Cancer Immunology Research 3(2):184 (2015) PMID 25527357

    The B7 family plays a critical role in both positive and negative regulation of immune responses by engaging a variety of receptors on lymphocytes. Importantly, blocking coinhibitory molecules using antibodies specific for CTLA-4 and PD-1 enhances tumor immunity in a subset of patients. Therefor...
  4. T-cell STAT3 is required for the maintenance of humoral immunity to LCMV.

    European Journal of Immunology 45(2):418 (2015) PMID 25393615 PMCID PMC4383653

    STAT3 is a critical transcription factor activated downstream of cytokine signaling and is integral for the function of multiple immune cell types. Human mutations in STAT3 cause primary immunodeficiency resulting in impaired control of a variety of infections, including reactivation of latent v...
  5. T-cell STAT3 is required for the maintenance of humoral immunity to LCMV.

    European Journal of Immunology 45(2):418 (2015) PMID 25393615

    STAT3 is a critical transcription factor activated downstream of cytokine signaling and is integral for the function of multiple immune cell types. Human mutations in STAT3 cause primary immunodeficiency resulting in impaired control of a variety of infections, including reactivation of latent v...
  6. B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.

    Cancer Immunology Research 3(2):184 (2015) PMID 25527357

    The B7 family plays a critical role in both positive and negative regulation of immune responses by engaging a variety of receptors on lymphocytes. Importantly, blocking coinhibitory molecules using antibodies specific for CTLA-4 and PD-1 enhances tumor immunity in a subset of patients. Therefor...
  7. NK cells regulating T cell responses: mechanisms and outcome.

    Trends in Immunology 36(1):49 (2015) PMID 25432489

    Natural killer (NK) cells are important innate effectors in immunity. NK cells also have a role in the regulation of the adaptive immune response, and have been shown, in different contexts, to stimulate or inhibit T cell responses. Recent findings have expanded our understanding of the mechanis...
  8. USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2.

    PLoS ONE 10(6):e0129365 (2015) PMID 26046984 PMCID PMC4457862

    USP18 (Ubiquitin-like specific protease 18) is an enzyme cleaving ubiquitin from target proteins. USP18 plays a pivotal role in antiviral and antibacterial immune responses. On the other hand, ubiquitination participates in the regulation of several ion channels and transporters. USP18 sensitivi...
  9. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

    Nature Communications 6:6217 (2015) PMID 25692415 PMCID PMC4346637

    B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influ...
  10. NK cells regulating T cell responses: mechanisms and outcome.

    Trends in Immunology 36(1):49 (2015) PMID 25432489

    Natural killer (NK) cells are important innate effectors in immunity. NK cells also have a role in the regulation of the adaptive immune response, and have been shown, in different contexts, to stimulate or inhibit T cell responses. Recent findings have expanded our understanding of the mechanis...
  11. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

    Nature Communications 6:6217 (2015) PMID 25692415 PMCID PMC4346637

    B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influ...
  12. Conjugated bilirubin triggers anemia by inducing erythrocyte death.

    Hepatology 61(1):275 (2015) PMID 25065608 PMCID PMC4303990

    Hepatic failure is commonly associated with anemia, which may result from gastrointestinal bleeding, vitamin deficiency, or liver-damaging diseases, such as infection and alcohol intoxication. At least in theory, anemia during hepatic failure may result from accelerated clearance of circulating ...
  13. Conjugated bilirubin triggers anemia by inducing erythrocyte death.

    Hepatology 61(1):275 (2015) PMID 25065608 PMCID PMC4303990

    Hepatic failure is commonly associated with anemia, which may result from gastrointestinal bleeding, vitamin deficiency, or liver-damaging diseases, such as infection and alcohol intoxication. At least in theory, anemia during hepatic failure may result from accelerated clearance of circulating ...
  14. Activated CD8+ T cells induce expansion of Vβ5+ regulatory T cells via TNFR2 signaling.

    Journal of Immunology 193(6):2952 (2014) PMID 25098294 PMCID PMC4157120

    Vβ5(+) regulatory T cells (Tregs), which are specific for a mouse endogenous retroviral superantigen, become activated and proliferate in response to Friend virus (FV) infection. We previously reported that FV-induced expansion of this Treg subset was dependent on CD8(+) T cells and TNF-α, but i...
  15. Activated CD8+ T cells induce expansion of Vβ5+ regulatory T cells via TNFR2 signaling.

    Journal of Immunology 193(6):2952 (2014) PMID 25098294 PMCID PMC4157120

    Vβ5(+) regulatory T cells (Tregs), which are specific for a mouse endogenous retroviral superantigen, become activated and proliferate in response to Friend virus (FV) infection. We previously reported that FV-induced expansion of this Treg subset was dependent on CD8(+) T cells and TNF-α, but i...
  16. Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1.

    Journal of Clinical Investigation 124(8):3455 (2014) PMID 25003188 PMCID PMC4109559

    During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression of viral-specific T cell responses, the r...
  17. Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1.

    Journal of Clinical Investigation 124(8):3455 (2014) PMID 25003188 PMCID PMC4109559

    During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression of viral-specific T cell responses, the r...
  18. Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1.

    Journal of Clinical Investigation 124(8):3455 (2014) PMID 25003188 PMCID PMC4109559

    During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression of viral-specific T cell responses, the r...
  19. Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.

    Immunity 40(6):949 (2014) PMID 24909887

    Despite development of new antiviral drugs, viral infections are still a major health problem. The most potent antiviral defense mechanism is the innate production of type I interferon (IFN-I), which not only limits virus replication but also promotes antiviral T cell immunity through mechanisms...
  20. Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.

    Immunity 40(6):949 (2014) PMID 24909887

    Despite development of new antiviral drugs, viral infections are still a major health problem. The most potent antiviral defense mechanism is the innate production of type I interferon (IFN-I), which not only limits virus replication but also promotes antiviral T cell immunity through mechanisms...