1. Space exploration by dendritic cells requires maintenance of myosin II activity by IP3 receptor 1.

    EMBO Journal 34(6):798 (2015) PMID 25637353 PMCID PMC4369315

    Dendritic cells (DCs) patrol the interstitial space of peripheral tissues. The mechanisms that regulate their migration in such constrained environment remain unknown. We here investigated the role of calcium in immature DCs migrating in confinement. We found that they displayed calcium oscillat...
  2. CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans.

    PLOS Medicine 12(3):e1001796 (2015) PMID 25734483 PMCID PMC4348493

    Chronic lymphocytic leukemia (CLL), the most common adulthood leukemia, is characterized by the accumulation of abnormal CD5+ B lymphocytes, which results in a progressive failure of the immune system. Despite intense research efforts, drug resistance remains a major cause of treatment failure i...
  3. CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans.

    PLOS Medicine 12(3):e1001796 (2015) PMID 25734483 PMCID PMC4348493

    Chronic lymphocytic leukemia (CLL), the most common adulthood leukemia, is characterized by the accumulation of abnormal CD5+ B lymphocytes, which results in a progressive failure of the immune system. Despite intense research efforts, drug resistance remains a major cause of treatment failure i...
  4. [Mast cells aggravate sepsis in mice by inhibiting peritoneal macrophage phagocytosis].

    médecine/sciences 31(2):127 (2015) PMID 25744255

  5. Mast cells in renal inflammation and fibrosis: lessons learnt from animal studies.

    Molecular Immunology 63(1):86 (2015) PMID 24793464

    Mast cells are hematopoietic cells involved in inflammation and immunity and have been recognized also as important effector cells in kidney inflammation. In humans, only a few mast cells reside in kidneys constitutively but in progressive renal diseases their numbers increase substantially repr...
  6. Mast cells in renal inflammation and fibrosis: lessons learnt from animal studies.

    Molecular Immunology 63(1):86 (2015) PMID 24793464

    Mast cells are hematopoietic cells involved in inflammation and immunity and have been recognized also as important effector cells in kidney inflammation. In humans, only a few mast cells reside in kidneys constitutively but in progressive renal diseases their numbers increase substantially repr...
  7. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  8. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  9. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  10. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

    Journal of Clinical Investigation 124(10):4577 (2014) PMID 25180604 PMCID PMC4191002

    Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the peritoneal cavity to control infection, but the role of...
  11. Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

    Journal of Clinical Investigation 124(9):3945 (2014) PMID 25061875 PMCID PMC4151227

    Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developi...
  12. Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

    Journal of Clinical Investigation 124(9):3945 (2014) PMID 25061875 PMCID PMC4151227

    Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developi...
  13. Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

    Journal of Clinical Investigation 124(9):3945 (2014) PMID 25061875 PMCID PMC4151227

    Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developi...
  14. Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations.

    PLoS ONE 9(12):e115256 (2014) PMID 25531103

    TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart, particularly in the atria or conduction tissue. Mutations in the Trpm4 gene were recently associated with several human conduction disorders such as Brugada syndrome. TRPM4 channel has also been implicated at the vent...
  15. Calcium channels in Fc receptor signaling.

    Current Topics in Microbiology and Immunology 382:95 (2014) PMID 25116097

    The calcium ion (Ca(2+)) is the main common second messenger involved in signaling transduction subsequent to immunoreceptor activation. Its rapid intracellular elevation induces multiple cellular responses, such as secretion, proliferation, mobility, and gene transcription. Intracellular levels...
  16. Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations.

    PLoS ONE 9(12):e115256 (2014) PMID 25531103 PMCID PMC4274076

    TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart, particularly in the atria or conduction tissue. Mutations in the Trpm4 gene were recently associated with several human conduction disorders such as Brugada syndrome. TRPM4 channel has also been implicated at the vent...
  17. Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations.

    PLoS ONE 9(12):e115256 (2014) PMID 25531103

    TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart, particularly in the atria or conduction tissue. Mutations in the Trpm4 gene were recently associated with several human conduction disorders such as Brugada syndrome. TRPM4 channel has also been implicated at the vent...
  18. Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations.

    PLoS ONE 9(12):e115256 (2014) PMID 25531103 PMCID PMC4274076

    TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart, particularly in the atria or conduction tissue. Mutations in the Trpm4 gene were recently associated with several human conduction disorders such as Brugada syndrome. TRPM4 channel has also been implicated at the vent...
  19. Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations.

    PLoS ONE 9(12):e115256 (2014) PMID 25531103 PMCID PMC4274076

    TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart, particularly in the atria or conduction tissue. Mutations in the Trpm4 gene were recently associated with several human conduction disorders such as Brugada syndrome. TRPM4 channel has also been implicated at the vent...
  20. Calcium channels in Fc receptor signaling.

    Current Topics in Microbiology and Immunology 382:95 (2014) PMID 25116097

    The calcium ion (Ca(2+)) is the main common second messenger involved in signaling transduction subsequent to immunoreceptor activation. Its rapid intracellular elevation induces multiple cellular responses, such as secretion, proliferation, mobility, and gene transcription. Intracellular levels...