1. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.

    Nature Communications 6:7339 (2015) PMID 26081744

    Diseases of lipid metabolism are a major cause of human morbidity, but no animal model entirely recapitulates human lipoprotein metabolism. Here we develop a xenograft mouse model using hepatocytes from a patient with familial hypercholesterolaemia caused by loss-of-function mutations in the low...
  2. Recruitment of Th1 effector cells in human tuberculosis: hierarchy of chemokine receptor(s) and their ligands.

    Cytokine 63(1):43 (2013) PMID 23643185

    Selective recruitment of IFN-γ biased Th1 effector cells at the pathologic site(s) determines the local immunity of tuberculosis (TB). We observed the enrichment of CXCR3, CCR5 and CD11a(high) T cells in the peripheral blood, pleural fluid and bronchoalveolar lavage of TB pleural effusion (TB-PE...
  3. Recruitment of Th1 effector cells in human tuberculosis: Hierarchy of chemokine receptor(s) and their ligands

    Cytokine 63(1):43 (2013)

    • Enrichment of CXCR3+CCR5+CD11ahigh T cells in PE and BAL of TB-PE & MTB. • Highest number of CXCR3+CCR5+ cells among activated lymphocytes in TB-PE. ...
  4. Recruitment of Th1 effector cells in human tuberculosis: hierarchy of chemokine receptor(s) and their ligands.

    Cytokine 63(1):43 (2013) PMID 23643185

    Selective recruitment of IFN-γ biased Th1 effector cells at the pathologic site(s) determines the local immunity of tuberculosis (TB). We observed the enrichment of CXCR3, CCR5 and CD11a(high) T cells in the peripheral blood, pleural fluid and bronchoalveolar lavage of TB pleural effusion (TB-PE...
  5. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop.

    Nature Cell Biology 15(6):647 (2013) PMID 23604321 PMCID PMC3699877

    The lysosomal-autophagic pathway is activated by starvation and plays an important role in both cellular clearance and lipid catabolism. However, the transcriptional regulation of this pathway in response to metabolic cues is uncharacterized. Here we show that the transcription factor EB (TFEB),...
  6. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop.

    Nature Cell Biology 15(6):647 (2013) PMID 23604321 PMCID PMC3699877

    The lysosomal-autophagic pathway is activated by starvation and plays an important role in both cellular clearance and lipid catabolism. However, the transcriptional regulation of this pathway in response to metabolic cues is uncharacterized. Here we show that the transcription factor EB (TFEB),...
  7. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop.

    Nature Cell Biology 15(6):647 (2013) PMID 23604321 PMCID PMC3699877

    The lysosomal-autophagic pathway is activated by starvation and plays an important role in both cellular clearance and lipid catabolism. However, the transcriptional regulation of this pathway in response to metabolic cues is uncharacterized. Here we show that the transcription factor EB (TFEB),...
  8. Prevalence of and risk factors for lead poisoning in young children in Bangladesh.

    Journal of Health, Population and Nutrition 30(4):404 (2012) PMID 23304906 PMCID PMC3763611

    Lead poisoning is a major public-health problem in Bangladesh. A cross-sectional study was conducted to determine the extent of and risk factors for elevated blood lead levels (BLLs) in children in Bangladesh during September 2007-July 2009. The study included 919 children aged less than 16 year...
  9. Prevalence of and risk factors for lead poisoning in young children in Bangladesh.

    Journal of Health, Population and Nutrition 30(4):404 (2012) PMID 23304906 PMCID PMC3763611

    Lead poisoning is a major public-health problem in Bangladesh. A cross-sectional study was conducted to determine the extent of and risk factors for elevated blood lead levels (BLLs) in children in Bangladesh during September 2007-July 2009. The study included 919 children aged less than 16 year...
  10. Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues.

    Aging Cell 10(6):996 (2011) PMID 21895961 PMCID PMC3215833

    Aging is associated with increased adiposity in white adipose tissues and impaired thermogenesis in brown adipose tissues; both contribute to increased incidences of obesity and type 2 diabetes. Ghrelin is the only known circulating orexigenic hormone that promotes adiposity. In this study, we s...
  11. Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues.

    Aging Cell 10(6):996 (2011) PMID 21895961 PMCID PMC3215833

    Aging is associated with increased adiposity in white adipose tissues and impaired thermogenesis in brown adipose tissues; both contribute to increased incidences of obesity and type 2 diabetes. Ghrelin is the only known circulating orexigenic hormone that promotes adiposity. In this study, we s...
  12. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys.

    Science Translational Medicine 3(108):108ra112 (2011) PMID 22072637 PMCID PMC3666164

    Obesity, defined as body mass index greater than 30, is a leading cause of morbidity and mortality and a financial burden worldwide. Despite significant efforts in the past decade, very few drugs have been successfully developed for the treatment of obese patients. Biological differences between...
  13. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys.

    Science Translational Medicine 3(108):108ra112 (2011) PMID 22072637 PMCID PMC3666164

    Obesity, defined as body mass index greater than 30, is a leading cause of morbidity and mortality and a financial burden worldwide. Despite significant efforts in the past decade, very few drugs have been successfully developed for the treatment of obese patients. Biological differences between...
  14. The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice.

    Journal of Biological Chemistry 285(52):40581 (2010) PMID 20956520 PMCID PMC3003357

    The triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid (CDDO) and its methyl ester (CDDO-Me) are undergoing clinical trials in cancer and leukemia therapy. Here we report that CDDO-Me ameliorates diabetes in high fat diet-fed type 2 diabetic mice and in Lepr(db/db) mice. CDDO-Me reduces ...
  15. The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice.

    Journal of Biological Chemistry 285(52):40581 (2010) PMID 20956520 PMCID PMC3003357

    The triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid (CDDO) and its methyl ester (CDDO-Me) are undergoing clinical trials in cancer and leukemia therapy. Here we report that CDDO-Me ameliorates diabetes in high fat diet-fed type 2 diabetic mice and in Lepr(db/db) mice. CDDO-Me reduces ...
  16. The coactivator SRC-1 is an essential coordinator of hepatic glucose production.

    Cell Metabolism 12(6):606 (2010) PMID 21109193 PMCID PMC3024581

    Gluconeogenesis makes a major contribution to hepatic glucose production, a process critical for survival in mammals. In this study, we identify the p160 family member, SRC-1, as a key coordinator of the hepatic gluconeogenic program in vivo. SRC-1-null mice displayed hypoglycemia secondary to a...
  17. Second trimester pregnancy termination with 400 μg vaginal misoprostol: efficacy and safety.

    BioScience Trends 4(6):351 (2010) PMID 21248435

    The present study was designed to evaluate the efficacy and safety of misoprostol (400 μg) given intravaginally repeated at 6 hourly intervals for a maximum of 6 doses for second-trimester pregnancy terminations. The study was conducted on women who had to undergo pregnancy termination between 1...
  18. The coactivator SRC-1 is an essential coordinator of hepatic glucose production.

    Cell Metabolism 12(6):606 (2010) PMID 21109193 PMCID PMC3024581

    Gluconeogenesis makes a major contribution to hepatic glucose production, a process critical for survival in mammals. In this study, we identify the p160 family member, SRC-1, as a key coordinator of the hepatic gluconeogenic program in vivo. SRC-1-null mice displayed hypoglycemia secondary to a...
  19. Second trimester pregnancy termination with 400 μg vaginal misoprostol: efficacy and safety.

    BioScience Trends 4(6):351 (2010) PMID 21248435

    The present study was designed to evaluate the efficacy and safety of misoprostol (400 μg) given intravaginally repeated at 6 hourly intervals for a maximum of 6 doses for second-trimester pregnancy terminations. The study was conducted on women who had to undergo pregnancy termination between 1...
  20. The Coactivator SRC-1 Is an Essential Coordinator of Hepatic Glucose Production

    Cell Metabolism 12(6):606 (2010)

    Gluconeogenesis makes a major contribution to hepatic glucose production, a process critical for survival in mammals. In this study, we identify the p160 family member, SRC-1, as a key coordinator of the hepatic gluconeogenic program in vivo. SRC-1-null mice displayed hypoglycemia secondary...