Nitrogen remobilization and conservation, and underlying senescence-associated gene expression in the perennial switchgrass Panicum virgatum.
New Phytologist 211(1):75 (2016)
Improving nitrogen (N) remobilization from aboveground to underground organs during yearly shoot senescence is an important goal for sustainable production of switchgrass (Panicum virgatum) as a biofuel crop. Little is known about the genetic control of senescence and N use efficiency in perenni...
Hepatoprotective effect of flavonoids from Cirsium japonicum DC on hepatotoxicity in comparison with silymarin.
Food & Function 7(5):2179 (2016)
Cirsium japonicum DC is a perennial plant that is widely distributed throughout China. Flavonoids are the major active constituents of C. japonicum, which has been reported to possess many bioactivities. This study was designed to investigate the protective effects of flavonoids from C. japonicu...
Anti-tumor angiogenesis effect of a new compound: B-9-3 through interference with VEGFR2 signaling.
Tumor Biology 37(5):6107 (2016)
B-9-3, a derivative of harmine, was first synthesized in our laboratory. We have reported that B-9-3 has an anti-proliferative effect against human lung cancer cells via induction of apoptosis and inhibition of cell migration. In the present study, we first studied that the anti-tumor angiogenes...
Randomized Comparison of the Crush Versus the Culotte Stenting for Coronary Artery Bifurcation Lesions.
Chinese Medical Journal 129(5):505 (2016)
The crush and the culotte stenting were both reported to be effective for complex bifurcation lesion treatment. However, their comparative performance remains elusive.
A total of 300 patients with coronary bifurcation lesions were randomly assigned to crush (n = 150) and culotte (n = 150) treatm...
Identifying anti-cancer drug response related genes using an integrative analysis of transcriptomic and genomic variations with cell line-based drug perturbations.
Oncotarget 7(8):9404 (2016)
Clinical responses to anti-cancer therapies often only benefit a defined subset of patients. Predicting the best treatment strategy hinges on our ability to effectively translate genomic data into actionable information on drug responses.
To achieve this goal, we compiled a comprehensive collect...
A new isoflavanone from the trunk of Horsfieldia pandurifolia.
Natural Product Research 30(2):131 (2016)
A new isoflavanone, 2,2'-epoxy-4'-methoxy-3,7-dihydroxyisoflavanone (1), and a new natural coumaranone, 2-hyroxy-2-(4'-methoxybenzyl)-6-methoxy-3-coumaranone (2), along with 26 known compounds, were first isolated from the trunk of Horsfieldia pandurifolia. Their structures were elucidated by th...
Ultra-precise detection of mutations by droplet-based amplification of circularized DNA.
BMC Genomics 17(1):214 (2016)
NGS (next generation sequencing) has been widely used in studies of biological processes, ranging from microbial evolution to cancer genomics. However, the error rate of NGS (0.1 % ~ 1 %) is still remaining a great challenge for comprehensively investigating the low frequency variations, and the...
Bacterial regulon modeling and prediction based on systematic cis regulatory motif analyses.
Scientific reports 6:23030 (2016)
Regulons are the basic units of the response system in a bacterial cell, and each consists of a set of transcriptionally co-regulated operons. Regulon elucidation is the basis for studying the bacterial global transcriptional regulation network. In this study, we designed a novel co-regulation s...
Ultra-dense SNP genetic map construction and identification of SiDt gene controlling the determinate growth habit in Sesamum indicum L.
Scientific reports 6:31556 (2016)
Sesame (Sesamum indicum L.) is an important oilseed crop and has an indeterminate growth habit. Here we resequenced the genomes of the parents and 120 progeny of an F2 population derived from crossing Yuzhi 11 (indeterminate, Dt) and Yuzhi DS899 (determinate, dt1), and constructed an ultra-dense...
Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer.
Cell Research 26(1):103 (2016)
Both 5-methylcytosine (5mC) and its oxidized form 5-hydroxymethylcytosine (5hmC) have been proposed to be involved in tumorigenesis. Because the readout of the broadly used 5mC mapping method, bisulfite sequencing (BS-seq), is the sum of 5mC and 5hmC levels, the 5mC/5hmC patterns and relationshi...
Deciphering relationship between microhomology and in-frame mutation occurrence in human CRISPR-based gene knockout.
Molecular Therapy â€” Nucleic Acids 5(6):e323 (2016)
An integrative and applicable phylogenetic footprinting framework for cis-regulatory motifs identification in prokaryotic genomes.
BMC Genomics 17:578 (2016)
Phylogenetic footprinting is an important computational technique for identifying cis-regulatory motifs in orthologous regulatory regions from multiple genomes, as motifs tend to evolve slower than their surrounding non-functional sequences. Its application, however, has several difficulties for...
Safflower yellow reduces lipid peroxidation, neuropathology, tau phosphorylation and ameliorates amyloid β-induced impairment of learning and memory in rats.
Biomedicine & Pharmacotherapy 76:153 (2015)
Insoluble plaques of amyloid β proteins (Aβ) and neurofibrillary tangles of hyperphosphorylated tau are key markers for Alzheimer's disease (AD). Safflower yellow (SY) is one of traditional Chinese medicine extracted from safflower, which is suggested to have therapeutic potential for neurodegen...
Analysis of Renal Artery Stenosis in Patients with Heart Failure: A RASHEF Study.
Chinese Medical Journal 128(20):2777 (2015)
Previous data are controversial about the association of renal artery stenosis (RAS) with clinical outcome in patients with heart failure. Definition of RAS in previous studies might not be appropriate. By definition of RAS with renal duplex sonography, we investigated the association of RAS wit...
MicroRNA Expression Profile Reveals miR-17-92 and miR-143-145 Cluster in Synchronous Colorectal Cancer.
Medicine (Baltimore) 94(32):e1297 (2015)
The expression of abnormal microRNA (miRNA, miR) is a ubiquitous feature of colorectal cancer (CRC). The pathological features and clinical behaviors of synchronous CRC have been comprehensively described; however, the expression profile of miRNA and small nucleolar RNA (snoRNA) in synchronous C...
A Comprehensive Strategy for Reconstruction of a Missing Midface.
Plastic and Reconstructive Surgery - Global Open 3(7):e446 (2015)
The loss of midface structures always leads to significant functional and cosmetic deficits, and the reconstruction work remains a challenge for surgeons. We report a rare case with severe midfacial defects involving the maxilla, nasal bone, and zygoma. This patient was treated with a comprehens...
Comprehensive characterization of the genomic alterations in human gastric cancer.
International Journal of Cancer 137(1):86 (2015)
Gastric cancer is one of the most prevalent and aggressive cancers worldwide, and its molecular mechanism remains largely elusive. Here we report the genomic landscape in primary gastric adenocarcinoma of human, based on the complete genome sequences of five pairs of cancer and matching normal s...
Tailoring Dielectric and Actuated Properties of Elastomer Composites by Bioinspired Poly(dopamine) Encapsulated Graphene Oxide.
ACS Applied Materials & Interfaces 7(20):10755 (2015)
In this study, we obtained dielectric elastomer composites with controllable dielectric and actuated properties by using a biomimetic method. We used dopamine (DA) to simultaneously coat the graphene oxide (GO) and partially reduce GO by self-polymerization of DA on GO. The poly(dopamine) (PDA) ...
Analysis of strand-specific RNA-seq data using machine learning reveals the structures of transcription units in Clostridium thermocellum.
Nucleic Acids Research 43(10):e67 (2015)
Identification of transcription units (TUs) encoded in a bacterial genome is essential to elucidation of transcriptional regulation of the organism. To gain a detailed understanding of the dynamically composed TU structures, we have used four strand-specific RNA-seq (ssRNA-seq) datasets collecte...
[Different maxillomandibular advancement methods for the treatment of severe obstructive sleep apneahypopnea syndrome].
Zhonghua kou qiang yi xue za zhi = Zhonghua kou... 50(4):202 (2015)
To review the outcomes of three different methods of maxillomandibular advancement for the treatment of severe obstructive sleep apnea-hypopnea syndrome (OSAHS).
Twenty-four patients with severe OSAHS from January 2011 to January 2014 treated by three different methods of maxillomandibular advan...