1. Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors.

    PLoS Biology 13(7):e1002194 (2015) PMID 26158621 PMCID PMC4497644

    Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of cannabinoids as therapeutic agents. For this reason, there is a tremendous medic...
  2. Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis.

    Antioxidants and Redox Signaling 22(15):1295 (2015) PMID 25706765

    Hippocampus is the brain center for memory formation, a process that requires synaptogenesis. However, hippocampus is dramatically compromised in Alzheimer's disease due to the accumulation of amyloid β-peptide, whose production is initiated by β-site APP Cleaving Enzyme 1 (BACE1). It is known t...
  3. Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain.

    Pharmacology research & perspectives 3(2):e00116 (2015) PMID 25692029

    The peripheral endogenous opioid system is critically involved in neuropathic and inflammatory pain generation as suggested by the modulation of opioid receptors expression and enkephalins (ENKs) release observed in these painful conditions. Accordingly, an innovative approach in the treatment o...
  4. Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain.

    Pharmacology research & perspectives 3(2):e00116 (2015) PMID 25692029 PMCID PMC4324690

    The peripheral endogenous opioid system is critically involved in neuropathic and inflammatory pain generation as suggested by the modulation of opioid receptors expression and enkephalins (ENKs) release observed in these painful conditions. Accordingly, an innovative approach in the treatment o...
  5. Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain.

    Pharmacology research & perspectives 3(2):e00116 (2015) PMID 25692029 PMCID PMC4324690

    The peripheral endogenous opioid system is critically involved in neuropathic and inflammatory pain generation as suggested by the modulation of opioid receptors expression and enkephalins (ENKs) release observed in these painful conditions. Accordingly, an innovative approach in the treatment o...
  6. A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons.

    Biological Psychiatry 77(4):404 (2015) PMID 25444168 PMCID PMC4297504

    The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory. Neural circuits underlying DOR activities have been poorly explored by genetic approaches. We used conditional mouse mutagenesis to elucidat...
  7. A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons.

    Biological Psychiatry 77(4):404 (2015) PMID 25444168

    The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory. Neural circuits underlying DOR activities have been poorly explored by genetic approaches. We used conditional mouse mutagenesis to elucidat...
  8. A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons.

    Biological Psychiatry 77(4):404 (2015) PMID 25444168 PMCID PMC4297504

    The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory. Neural circuits underlying DOR activities have been poorly explored by genetic approaches. We used conditional mouse mutagenesis to elucidat...
  9. A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons.

    Biological Psychiatry 77(4):404 (2015) PMID 25444168 PMCID PMC4297504

    The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory. Neural circuits underlying DOR activities have been poorly explored by genetic approaches. We used conditional mouse mutagenesis to elucidat...
  10. Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice.

    Brain 138(Pt 1):94 (2015) PMID 25392198

    Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder that associates with prominent memory and behavioural deficits. Patients' antibodies react with the N-terminal domain of the GluN1 (previously known as NR1) subunit of NMDAR causing in cultured neurons ...
  11. Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice.

    Brain 138(Pt 1):94 (2015) PMID 25392198 PMCID PMC4285189

    Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder that associates with prominent memory and behavioural deficits. Patients' antibodies react with the N-terminal domain of the GluN1 (previously known as NR1) subunit of NMDAR causing in cultured neurons ...
  12. Frustrated expected reward induces differential transcriptional changes in the mouse brain.

    Addiction Biology 20(1):22 (2015) PMID 25288320

    Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of fru...
  13. Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice.

    Brain 138(Pt 1):94 (2015) PMID 25392198

    Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder that associates with prominent memory and behavioural deficits. Patients' antibodies react with the N-terminal domain of the GluN1 (previously known as NR1) subunit of NMDAR causing in cultured neurons ...
  14. Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice.

    Journal of Alzheimer's Disease 43(3):977 (2015) PMID 25125475

    Several recent findings suggest that targeting the endogenous cannabinoid system can be considered as a potential therapeutic approach to treat Alzheimer's disease (AD). The present study supports this hypothesis demonstrating that delta-9-tetrahydrocannabinol (THC) or cannabidiol (CBD) botanica...
  15. Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice.

    Brain 138(Pt 1):94 (2015) PMID 25392198 PMCID PMC4285189

    Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder that associates with prominent memory and behavioural deficits. Patients' antibodies react with the N-terminal domain of the GluN1 (previously known as NR1) subunit of NMDAR causing in cultured neurons ...
  16. Frustrated expected reward induces differential transcriptional changes in the mouse brain.

    Addiction Biology 20(1):22 (2015) PMID 25288320

    Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of fru...
  17. Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice.

    Journal of Alzheimer's Disease 43(3):977 (2015) PMID 25125475

    Several recent findings suggest that targeting the endogenous cannabinoid system can be considered as a potential therapeutic approach to treat Alzheimer's disease (AD). The present study supports this hypothesis demonstrating that delta-9-tetrahydrocannabinol (THC) or cannabidiol (CBD) botanica...
  18. Cannabis-Based Medicine Reduces Multiple Pathological Processes in AβPP/PS1 Mice.

    Journal of Alzheimer's Disease 43(3):977 (2015) PMID 25125475

    Several recent findings suggest that targeting the endogenous cannabinoid system can be considered as a potential therapeutic approach to treat Alzheimer's disease (AD). The present study supports this hypothesis demonstrating that delta-9-tetrahydrocannabinol (THC) or cannabidiol (CBD) botanica...
  19. Cannabis-Based Medicine Reduces Multiple Pathological Processes in AβPP/PS1 Mice.

    Journal of Alzheimer's Disease 43(3):977 (2015) PMID 25125475

    Several recent findings suggest that targeting the endogenous cannabinoid system can be considered as a potential therapeutic approach to treat Alzheimer's disease (AD). The present study supports this hypothesis demonstrating that delta-9-tetrahydrocannabinol (THC) or cannabidiol (CBD) botanica...
  20. Frustrated expected reward induces differential transcriptional changes in the mouse brain.

    Addiction Biology 20(1):22 (2015) PMID 25288320

    Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of fru...