1. Ube3a imprinting impairs circadian robustness in angelman syndrome models.

    Current Biology 25(5):537 (2015) PMID 25660546 PMCID PMC4348236

    The paternal allele of Ube3a is silenced by imprinting in neurons, and Angelman syndrome (AS) is a disorder arising from a deletion or mutation of the maternal Ube3a allele, which thereby eliminates Ube3a neuronal expression. Sleep disorders such as short sleep duration and increased sleep onset...
  2. Controlling COR Competence: BCL-6 Regulates Neurogenesis and Tumor Suppression.

    Cancer Cell 26(6):773 (2014) PMID 25490438

    In this issue of Cancer Cell, Tiberi and colleagues describe a tumor-suppressor role for BCL6. In the cerebellum, BCL6 is required for the transition from proliferative precursor cell to a more differentiated immature neuron through repressing the expression of Hedgehog effectors, thus controlli...
  3. Controlling COR Competence: BCL-6 Regulates Neurogenesis and Tumor Suppression

    Cancer Cell 26(6):773 (2014)

    In this issue of Cancer Cell, Tiberi and colleagues describe a tumor-suppressor role for BCL6. In the cerebellum, BCL6 is required for the transition from proliferative precursor cell to a more differentiated immature neuron through repressing the expression of Hedgehog effectors, thus...
  4. Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression.

    Cancer Cell 26(6):773 (2014) PMID 25490438

    In this issue of Cancer Cell, Tiberi and colleagues describe a tumor-suppressor role for BCL6. In the cerebellum, BCL6 is required for the transition from proliferative precursor cell to a more differentiated immature neuron through repressing the expression of Hedgehog effectors, thus controlli...
  5. Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression.

    Cancer Cell 26(6):773 (2014) PMID 25490438

    In this issue of Cancer Cell, Tiberi and colleagues describe a tumor-suppressor role for BCL6. In the cerebellum, BCL6 is required for the transition from proliferative precursor cell to a more differentiated immature neuron through repressing the expression of Hedgehog effectors, thus controlli...
  6. Sonic hedgehog signaling in the postnatal brain

    Seminars in Cell & Developmental Biology 33:105 (2014)

    • Hedgehog signaling is required to establish adult neural stem cell niches. • Modulation of Hedgehog signaling regulates adult stem cell maintenance and identity....
  7. Sonic hedgehog signaling in the postnatal brain.

    Seminars in Cell & Developmental Biology 33:105 (2014) PMID 24862855 PMCID PMC4130786

    Sonic hedgehog (Shh) is a pleiotropic factor in the developing central nervous system (CNS), driving proliferation, specification, and axonal targeting in multiple sites within the forebrain, hindbrain, and spinal cord. Studies in embryonic CNS have shown how gradients of this morphogen are tran...
  8. Sonic hedgehog signaling in the postnatal brain.

    Seminars in Cell & Developmental Biology 33:105 (2014) PMID 24862855 PMCID PMC4130786

    Sonic hedgehog (Shh) is a pleiotropic factor in the developing central nervous system (CNS), driving proliferation, specification, and axonal targeting in multiple sites within the forebrain, hindbrain, and spinal cord. Studies in embryonic CNS have shown how gradients of this morphogen are tran...
  9. Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme.

    Frontiers in Oncology 3:182 (2013) PMID 23875172 PMCID PMC3708153

    Glioblastoma multiforme (GBM) is a clinically and pathologically heterogeneous brain tumor. Previous studies of transcriptional profiling have revealed biologically relevant GBM subtypes associated with specific mutations and dysregulated pathways. Here, we applied a modified proteome to uncover...
  10. Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme.

    Frontiers in Oncology 3:182 (2013) PMID 23875172 PMCID PMC3708153

    Glioblastoma multiforme (GBM) is a clinically and pathologically heterogeneous brain tumor. Previous studies of transcriptional profiling have revealed biologically relevant GBM subtypes associated with specific mutations and dysregulated pathways. Here, we applied a modified proteome to uncover...
  11. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.

    PNAS 109(22):8710 (2012) PMID 22586120 PMCID PMC3365162

    Although malignant astrocytomas are a leading cause of cancer-related death in children, rational therapeutic strategies are lacking. We previously identified activating mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) (BRAF(T1799A) encoding BRAF(V600E)) in association with hom...
  12. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.

    PNAS 109(22):8710 (2012) PMID 22586120 PMCID PMC3365162

    Although malignant astrocytomas are a leading cause of cancer-related death in children, rational therapeutic strategies are lacking. We previously identified activating mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) (BRAF(T1799A) encoding BRAF(V600E)) in association with hom...
  13. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.

    PNAS 109(22):8710 (2012) PMID 22586120 PMCID PMC3365162

    Although malignant astrocytomas are a leading cause of cancer-related death in children, rational therapeutic strategies are lacking. We previously identified activating mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) (BRAF(T1799A) encoding BRAF(V600E)) in association with hom...
  14. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.

    PNAS 109(22):8710 (2012) PMID 22586120 PMCID PMC3365162

    Although malignant astrocytomas are a leading cause of cancer-related death in children, rational therapeutic strategies are lacking. We previously identified activating mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) (BRAF(T1799A) encoding BRAF(V600E)) in association with hom...
  15. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.

    PNAS 109(22):8710 (2012) PMID 22586120 PMCID PMC3365162

    Although malignant astrocytomas are a leading cause of cancer-related death in children, rational therapeutic strategies are lacking. We previously identified activating mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) (BRAF(T1799A) encoding BRAF(V600E)) in association with hom...
  16. Corridors of migrating neurons in the human brain and their decline during infancy.

    Nature 478(7369):382 (2011) PMID 21964341 PMCID PMC3197903

    The subventricular zone of many adult non-human mammals generates large numbers of new neurons destined for the olfactory bulb. Along the walls of the lateral ventricles, immature neuronal progeny migrate in tangentially oriented chains that coalesce into a rostral migratory stream (RMS) connect...
  17. Corridors of migrating neurons in the human brain and their decline during infancy.

    Nature 478(7369):382 (2011) PMID 21964341 PMCID PMC3197903

    The subventricular zone of many adult non-human mammals generates large numbers of new neurons destined for the olfactory bulb. Along the walls of the lateral ventricles, immature neuronal progeny migrate in tangentially oriented chains that coalesce into a rostral migratory stream (RMS) connect...
  18. Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity

    Neuron 71(2):250 (2011)

    Neural stem cells (NSCs) persist in the subventricular zone (SVZ) of the adult brain. Location within this germinal region determines the type of neuronal progeny NSCs generate, but the mechanism of adult NSC positional specification remains unknown. We show that sonic hedgehog (Shh) s...
  19. Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity.

    Neuron 71(2):250 (2011) PMID 21791285 PMCID PMC3346180

    Neural stem cells (NSCs) persist in the subventricular zone (SVZ) of the adult brain. Location within this germinal region determines the type of neuronal progeny NSCs generate, but the mechanism of adult NSC positional specification remains unknown. We show that sonic hedgehog (Shh) signaling, ...
  20. Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain.

    Neuron 70(4):674 (2011) PMID 21609824 PMCID PMC3346178

    New neurons and glial cells are generated in an extensive germinal niche adjacent to the walls of the lateral ventricles in the adult brain. The primary progenitors (B1 cells) have astroglial characteristics but retain important neuroepithelial properties. Recent work shows how B1 cells contact ...