1. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.

    Biochemical and Biophysical Research Communicat... 460(1):88 (2015) PMID 25998737

    Reliance on Ca(2+) signaling has been well-preserved through the course of evolution. While the complexity of Ca(2+) signaling pathways has increased, activation of transcription factors including CREB by Ca(2+)/CaM-dependent kinases (CaMKs) has remained critical for long-term plasticity. In C. ...
  2. Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.

    PNAS 112(10):2935 (2015) PMID 25730884

    Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder precipitated by coffee, alcohol, and stress. We previously identified the causative gene but the function of the encoded protein remains unknown. We also generated a PNKD mouse model that revealed dys...
  3. Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.

    PNAS 112(10):2935 (2015) PMID 25730884 PMCID PMC4364199

    Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder precipitated by coffee, alcohol, and stress. We previously identified the causative gene but the function of the encoded protein remains unknown. We also generated a PNKD mouse model that revealed dys...
  4. γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression.

    Cell 159(2):281 (2014) PMID 25303525 PMCID PMC4201038

    Activity-dependent CREB phosphorylation and gene expression are critical for long-term neuronal plasticity. Local signaling at CaV1 channels triggers these events, but how information is relayed onward to the nucleus remains unclear. Here, we report a mechanism that mediates long-distance commun...
  5. CaV1.2 calcium channels: just cut out to be regulated?

    Neuron 82(5):939 (2014) PMID 24908477

    Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis et al. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within t...
  6. Virtual finger boosts three-dimensional imaging and microsurgery as well as terabyte volume image visualization and analysis.

    Nature Communications 5:4342 (2014) PMID 25014658 PMCID PMC4104457

    Three-dimensional (3D) bioimaging, visualization and data analysis are in strong need of powerful 3D exploration techniques. We develop virtual finger (VF) to generate 3D curves, points and regions-of-interest in the 3D space of a volumetric image with a single finger operation, such as a comput...
  7. Virtual finger boosts three-dimensional imaging and microsurgery as well as terabyte volume image visualization and analysis.

    Nature Communications 5:4342 (2014) PMID 25014658 PMCID PMC4104457

    Three-dimensional (3D) bioimaging, visualization and data analysis are in strong need of powerful 3D exploration techniques. We develop virtual finger (VF) to generate 3D curves, points and regions-of-interest in the 3D space of a volumetric image with a single finger operation, such as a comput...
  8. GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal.

    Nature Neuroscience 16(10):1436 (2013) PMID 23974710

    Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to...
  9. GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal.

    Nature Neuroscience 16(10):1436 (2013) PMID 23974710

    Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to...
  10. Ca2+ channel nanodomains boost local Ca2+ amplitude.

    PNAS 110(39):15794 (2013) PMID 24019485 PMCID PMC3785779

    Local Ca(2+) signals through voltage-gated Ca(2+) channels (CaVs) drive synaptic transmission, neural plasticity, and cardiac contraction. Despite the importance of these events, the fundamental relationship between flux through a single CaV channel and the Ca(2+) signaling concentration within ...
  11. Ca2+ channel nanodomains boost local Ca2+ amplitude.

    PNAS 110(39):15794 (2013) PMID 24019485 PMCID PMC3785779

    Local Ca(2+) signals through voltage-gated Ca(2+) channels (CaVs) drive synaptic transmission, neural plasticity, and cardiac contraction. Despite the importance of these events, the fundamental relationship between flux through a single CaV channel and the Ca(2+) signaling concentration within ...
  12. GABAergic Projection Neurons Route Selective Olfactory Inputs to Specific Higher-Order Neurons

    Neuron 79(5):917 (2013)

    We characterize an inhibitory circuit motif in the Drosophila olfactory system, parallel inhibition, which differs from feedforward or feedback inhibition. Excitatory and GABAergic inhibitory projection neurons (ePNs and iPNs) each receive input from antennal lobe glomeruli and send pa...
  13. GABAergic projection neurons route selective olfactory inputs to specific higher-order neurons.

    Neuron 79(5):917 (2013) PMID 24012005 PMCID PMC3838762

    We characterize an inhibitory circuit motif in the Drosophila olfactory system, parallel inhibition, which differs from feedforward or feedback inhibition. Excitatory and GABAergic inhibitory projection neurons (ePNs and iPNs) each receive input from antennal lobe glomeruli and send parallel out...
  14. GABAergic projection neurons route selective olfactory inputs to specific higher-order neurons.

    Neuron 79(5):917 (2013) PMID 24012005 PMCID PMC3838762

    We characterize an inhibitory circuit motif in the Drosophila olfactory system, parallel inhibition, which differs from feedforward or feedback inhibition. Excitatory and GABAergic inhibitory projection neurons (ePNs and iPNs) each receive input from antennal lobe glomeruli and send parallel out...
  15. Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons.

    Nature 500(7463):458 (2013) PMID 23913275

    Neuromodulatory control by oxytocin is essential to a wide range of social, parental and stress-related behaviours. Autism spectrum disorders (ASD) are associated with deficiencies in oxytocin levels and with genetic alterations of the oxytocin receptor (OXTR). Thirty years ago, Mühlethaler et a...
  16. Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons.

    Nature 500(7463):458 (2013) PMID 23913275

    Neuromodulatory control by oxytocin is essential to a wide range of social, parental and stress-related behaviours. Autism spectrum disorders (ASD) are associated with deficiencies in oxytocin levels and with genetic alterations of the oxytocin receptor (OXTR). Thirty years ago, Mühlethaler et a...
  17. AMPA receptor exchange underlies transient memory destabilization on retrieval.

    PNAS 110(20):8218 (2013) PMID 23630279 PMCID PMC3657785

    A consolidated memory can be transiently destabilized by memory retrieval, after which memories are reconsolidated within a few hours; however, the molecular substrates underlying this destabilization process remain essentially unknown. Here we show that at lateral amygdala synapses, fear memory...
  18. AMPA receptor exchange underlies transient memory destabilization on retrieval.

    PNAS 110(20):8218 (2013) PMID 23630279 PMCID PMC3657785

    A consolidated memory can be transiently destabilized by memory retrieval, after which memories are reconsolidated within a few hours; however, the molecular substrates underlying this destabilization process remain essentially unknown. Here we show that at lateral amygdala synapses, fear memory...
  19. The impact of NMDA receptor hypofunction on GABAergic interneurons in the pathophysiology of schizophrenia

    Schizophrenia Research (2013)

    While the dopamine hypothesis has dominated schizophrenia research for several decades, more recent studies have highlighted the role of fast synaptic transmitters and their receptors in schizophrenia etiology. Here we review evidence that schizophrenia is associated with a reduction i...
  20. Exploring the dominant role of Cav1 channels in signalling to the nucleus.

    Bioscience Reports 33(1):97 (2013) PMID 23088728 PMCID PMC3546354

    Calcium is important in controlling nuclear gene expression through the activation of multiple signal-transduction pathways in neurons. Compared with other voltage-gated calcium channels, Ca(V)1 channels demonstrate a considerable advantage in signalling to the nucleus. In this review, we summar...