Genetic insights into migraine and glutamate: a protagonist driving the headache.
Journal of the Neurological Sciences 367:258 (2016)
Migraine is a complex polygenic disorder that continues to be a great source of morbidity in the developed world with a prevalence of 12% in the Caucasian population. Genetic and pharmacological studies have implicated the glutamate pathway in migraine pathophysiology. Glutamate profoundly impac...
Temporal Trends in Colorectal Cancer Screening among Asian Americans.
Cancer Epidemiology Biomarkers & Prevention 25(6):995 (2016)
Asian Americans (AA) are less likely to be screened for colorectal cancer compared with non-Hispanic Whites (NHW), with a widening disparity for some AA subgroups in the early 2000s. Whether these patterns have continued in more recent years is unknown. We examined temporal trends in colorectal ...
Mammography Use and Physician Recommendation After the 2009 U.S. Preventive Services Task Force Breast Cancer Screening Recommendations.
American Journal of Preventive Medicine 50(5):e123 (2016)
In 2009, the U.S. Preventive Services Task Force (USPSTF) no longer recommended routine mammography for women aged 40-49 and ≥75 years (younger and older women, respectively). Whether mammography usage and physician recommendation among younger and older women changed in response to these recomm...
Updates on the genetics and the clinical impacts on phaeochromocytoma and paraganglioma in the new era.
Critical Reviews in Oncology/Hematology 100:190 (2016)
Genetic mutations of phaeochromocytoma (PCC) and paraganglioma (PGL) are mainly classified into two major clusters. Cluster 1 mutations are involved with the pseudo hypoxic pathway and comprised of PHD2, VHL, SDHx, IDH, HIF2A, MDH2 and FH mutated PCC/PGL. Cluster 2 mutations are associated with ...
What Predicts an Advanced-Stage Diagnosis of Breast Cancer? Sorting Out the Influence of Method of Detection, Access to Care, and Biologic Factors.
Cancer Epidemiology Biomarkers & Prevention 25(4):613 (2016)
Multiple studies have yielded important findings regarding the determinants of an advanced-stage diagnosis of breast cancer. We seek to advance this line of inquiry through a broadened conceptual framework and accompanying statistical modeling strategy that recognize the dual importance of acces...
Next-generation sequencing identifies novel CACNA1A gene mutations in episodic ataxia type 2.
Molecular Genetics & Genomic Medicine 4(2):211 (2016)
Episodic Ataxia type 2 (EA2) is a rare autosomal dominantly inherited neurological disorder characterized by recurrent disabling imbalance, vertigo, and episodes of ataxia lasting minutes to hours. EA2 is caused most often by loss of function mutations of the calcium channel gene CACNA1A. In add...
Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study.
Gene 576(1 Pt 2):256 (2016)
Breast cancer (BC) is primarily considered a genetic disorder with a complex interplay of factors including age, gender, ethnicity, family history, personal history and lifestyle with associated hormonal and non-hormonal risk factors. The SNP rs2910164 in miR146a (a G to C polymorphism) was prev...
Breast cancer statistics, 2015: Convergence of incidence rates between black and white women.
CA: A Cancer Journal for Clinicians 66(1):31 (2016)
In this article, the American Cancer Society provides an overview of female breast cancer statistics in the United States, including data on incidence, mortality, survival, and screening. Approximately 231,840 new cases of invasive breast cancer and 40,290 breast cancer deaths are expected to oc...
Cancer screening in the United States, 2016: A review of current American Cancer Society guidelines and current issues in cancer screening.
CA: A Cancer Journal for Clinicians 66(2):96 (2016)
Each year the American Cancer Society (ACS) publishes a summary of its guidelines for early cancer detection, data and trends in cancer screening rates, and select issues related to cancer screening. In this issue of the journal, we summarize current ACS cancer screening guidelines, including th...
Four Amino Acid Changes in HIV-2 Protease Confer Class-Wide Sensitivity to Protease Inhibitors.
Journal of Virology 90(2):1062 (2016)
Protease is essential for retroviral replication, and protease inhibitors (PI) are important for treating HIV infection. HIV-2 exhibits intrinsic resistance to most FDA-approved HIV-1 PI, retaining clinically useful susceptibility only to lopinavir, darunavir, and saquinavir. The mechanisms for ...
How many individuals will need to be screened to increase colorectal cancer screening prevalence to 80% by 2018?
Cancer 121(23):4258 (2015)
A recent study estimates that 277,000 colorectal cancer (CRC) cases and 203,000 CRC deaths will be averted between 2013 and 2030 if the National Colorectal Cancer Roundtable goal of increasing CRC screening prevalence to 80% by 2018 is reached. However, the number of individuals who need to be s...
The Nucleoside Analog BMS-986001 Shows Greater In Vitro Activity against HIV-2 than against HIV-1.
Antimicrobial Agents and Chemotherapy 59(12):7437 (2015)
Treatment options for individuals infected with human immunodeficiency virus type 2 (HIV-2) are restricted by the intrinsic resistance of the virus to nonnucleoside reverse transcriptase inhibitors (NNRTIs) and the reduced susceptibility of HIV-2 to several protease inhibitors (PIs) used in anti...
Future Research Directions in Asthma. An NHLBI Working Group Report.
American Journal of Respiratory and Critical Ca... 192(11):1366 (2015)
Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important cl...
Breast Tumor Prognostic Characteristics and Biennial vs Annual Mammography, Age, and Menopausal Status.
JAMA Oncology 1(8):1069 (2015)
Screening mammography intervals remain under debate in the United States.
To compare the proportion of breast cancers with less vs more favorable prognostic characteristics in women screening annually vs biennially by age, menopausal status, and postmenopausal hormone therapy (HT) use.
This was ...
Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society.
JAMA 314(15):1599 (2015)
Breast cancer is a leading cause of premature mortality among US women. Early detection has been shown to be associated with reduced breast cancer morbidity and mortality.
To update the American Cancer Society (ACS) 2003 breast cancer screening guideline for women at average risk for breast canc...
Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectives.
Critical Reviews in Oncology/Hematology 96(1):9 (2015)
Cancer stem cells (CSCs) are a vital subpopulation of cells to target for the treatment of cancers. In oesophageal squamous cell carcinoma (ESCC), there are several markers such as CD44, ALDH, Pygo2, MAML1, Twist1, Musashi1, Side population (SP), CD271 and CD90 that have been proposed to identif...
Elimination of cost-sharing and receipt of screening for colorectal and breast cancer.
Cancer 121(18):3272 (2015)
The aim of the cost-sharing provision of the Patient Protection and Affordable Care Act (ACA) was to reduce financial barriers for preventive services, including screening for colorectal cancer (CRC) and breast cancer (BC) among privately and Medicare-insured individuals. Whether the provision h...
Translational potential of cancer stem cells: A review of the detection of cancer stem cells and their roles in cancer recurrence and cancer treatment.
Experimental Cell Research 335(1):135 (2015)
Cancer stem cells (CSCs) are a subpopulation of cancer cells with many clinical implications in most cancer types. One important clinical implication of CSCs is their role in cancer metastases, as reflected by their ability to initiate and drive micro and macro-metastases. The other important co...
Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer.
Tumor Biology 36(7):5369 (2015)
Breast cancer incidence and mortality rates are increasing despite our current knowledge on the disease. Ninety-five percent of breast cancer cases correspond to sporadic forms of the disease and are believed to involve an interaction between environmental and genetic determinants. The microRNA ...
Beef Quality Assurance in Feedlots.
Veterinary Clinics of North America: Food Anima... 31(2):269 (2015)
This article discusses the Beef Quality Assurance (BQA) program, which was created by beef producers and veterinarians. The program has evolved from antibiotic residue avoidance to include animal handling, cattle comfort, food safety, and much more. It provides guidance to producers and veterina...