1. Large-Scale Examination of Factors Influencing Phosphopeptide Neutral Loss during Collision Induced Dissociation.

    Journal of the American Society for Mass Spectr... 26(7):1128 (2015) PMID 25851653 PMCID PMC4509682

    Collision-induced dissociation (CID) remains the predominant mass spectrometry-based method for identifying phosphorylation sites in complex mixtures. Unfortunately, the gas-phase reactivity of phosphoester bonds results in MS/MS spectra dominated by phosphoric acid (H3PO4) neutral loss events, ...
  2. Whole-genome characterization of chemoresistant ovarian cancer.

    Nature 521(7553):489 (2015) PMID 26017449

    Patients with high-grade serous ovarian cancer (HGSC) have experienced little improvement in overall survival, and standard treatment has not advanced beyond platinum-based combination chemotherapy, during the past 30 years. To understand the drivers of clinical phenotypes better, here we use wh...
  3. Quantitative Measurement of tissue damage and recovery within new T2w lesions in pediatric- and adult-onset multiple sclerosis.

    Multiple Sclerosis Journal 21(6):718 (2015) PMID 25480858

    Children and adolescents with relapsing-remitting multiple sclerosis (RRMS) have a similar T2 lesion burden as adults matched for disease duration. However, it is unknown whether the degree of tissue destruction within lesions is also similar. Persistent reduced T1-weighted signal intensity with...
  4. New ureteral access sheaths: a double standard.

    Urology 85(4):757 (2015) PMID 25661780

    To investigate the functional characteristics of the traditional and new single-wire ureteral access sheath (UAS) configurations relating to insertion, positioning, tissue injury, and durability. Four UAS were tested: Navigator HD (11/13F, Boston Scientific), Re-Trace (10/12F, Coloplast), Flexor...
  5. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.

    Science 347(6229):1436 (2015) PMID 25700176 PMCID PMC4437632

    Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment. We report the results of a moderate-scale sequencing study aimed at increasing the number of genes known to contribute to predisposition for ALS. We performed whole-exome sequencing of 2869 ALS...
  6. Normalization of white matter intensity on t1-weighted images of patients with acquired central nervous system demyelination.

    Journal of Neuroimaging 25(2):184 (2015) PMID 24942347

    Intensity variation between magnetic resonance images (MRI) hinders comparison of tissue intensity distributions in multicenter MRI studies of brain diseases. The available intensity normalization techniques generally work well in healthy subjects but not in the presence of pathologies that affe...
  7. Normalization of white matter intensity on t1-weighted images of patients with acquired central nervous system demyelination.

    Journal of Neuroimaging 25(2):184 (2015) PMID 24942347

    Intensity variation between magnetic resonance images (MRI) hinders comparison of tissue intensity distributions in multicenter MRI studies of brain diseases. The available intensity normalization techniques generally work well in healthy subjects but not in the presence of pathologies that affe...
  8. Sofosbuvir and ribavirin prevent recurrence of HCV infection after liver transplantation: an open-label study.

    Gastroenterology 148(1):100 (2015) PMID 25261839

    Patients with detectable hepatitis C virus (HCV) RNA at the time of liver transplantation universally experience recurrent HCV infection. Antiviral treatment before transplantation can prevent HCV recurrence, but existing interferon-based regimens are poorly tolerated and are either ineffective ...
  9. Transcriptional implications of intragenic DNA methylation in the oestrogen receptor alpha gene in breast cancer cells and tissues.

    BMC Cancer 15:337 (2015) PMID 25927974 PMCID PMC4424887

    DNA methylation variability regions (MVRs) across the oestrogen receptor alpha (ESR1) gene have been identified in peripheral blood cells from breast cancer patients and healthy individuals. In contrast to promoter methylation, gene body methylation may be important in maintaining active transcr...
  10. Sofosbuvir and ribavirin prevent recurrence of HCV infection after liver transplantation: an open-label study.

    Gastroenterology 148(1):100 (2015) PMID 25261839

    Patients with detectable hepatitis C virus (HCV) RNA at the time of liver transplantation universally experience recurrent HCV infection. Antiviral treatment before transplantation can prevent HCV recurrence, but existing interferon-based regimens are poorly tolerated and are either ineffective ...
  11. Temporal stability and determinants of white blood cell DNA methylation in the breakthrough generations study.

    Cancer Epidemiology Biomarkers & Prevention 24(1):221 (2015) PMID 25371448

    Epigenome-wide association studies (EWAS) using measurements of blood DNA methylation are performed to identify associations of methylation changes with environmental and lifestyle exposures and disease risk. However, little is known about the variation of methylation markers in the population a...
  12. Temporal stability and determinants of white blood cell DNA methylation in the breakthrough generations study.

    Cancer Epidemiology Biomarkers & Prevention 24(1):221 (2015) PMID 25371448

    Epigenome-wide association studies (EWAS) using measurements of blood DNA methylation are performed to identify associations of methylation changes with environmental and lifestyle exposures and disease risk. However, little is known about the variation of methylation markers in the population a...
  13. Temporal stability and determinants of white blood cell DNA methylation in the breakthrough generations study.

    Cancer Epidemiology Biomarkers & Prevention 24(1):221 (2015) PMID 25371448

    Epigenome-wide association studies (EWAS) using measurements of blood DNA methylation are performed to identify associations of methylation changes with environmental and lifestyle exposures and disease risk. However, little is known about the variation of methylation markers in the population a...
  14. Nomogram to predict uric acid kidney stones based on patient's age, BMI and 24-hour urine profiles: A multicentre validation.

    Canadian Urological Association Journal 9(3-4):E178 (2015) PMID 26085876 PMCID PMC4455636

    We performed a multicentre validation of a nomogram to predict uric acid kidney stones in two populations. We reviewed the kidney stone database of two institutions, searching for patients with kidney stones who had stone composition analysis and 24-hour urine collection from January 2010 to Dec...
  15. Temporal stability and determinants of white blood cell DNA methylation in the breakthrough generations study.

    Cancer Epidemiology Biomarkers & Prevention 24(1):221 (2015) PMID 25371448

    Epigenome-wide association studies (EWAS) using measurements of blood DNA methylation are performed to identify associations of methylation changes with environmental and lifestyle exposures and disease risk. However, little is known about the variation of methylation markers in the population a...
  16. An interferon-free antiviral regimen for HCV after liver transplantation.

    New England Journal of Medicine 371(25):2375 (2014) PMID 25386767

    Hepatitis C virus (HCV) infection is the leading indication for liver transplantation worldwide, and interferon-containing regimens are associated with low response rates owing to treatment-limiting toxic effects in immunosuppressed liver-transplant recipients. We evaluated the interferon-free r...
  17. An interferon-free antiviral regimen for HCV after liver transplantation.

    New England Journal of Medicine 371(25):2375 (2014) PMID 25386767

    Hepatitis C virus (HCV) infection is the leading indication for liver transplantation worldwide, and interferon-containing regimens are associated with low response rates owing to treatment-limiting toxic effects in immunosuppressed liver-transplant recipients. We evaluated the interferon-free r...
  18. An Interferon-free Antiviral Regimen for HCV after Liver Transplantation

    New England Journal of Medicine 371(25):2375 (2014) PMID 25386767

    Background Hepatitis C virus (HCV) infection is the leading indication for liver transplantation worldwide, and interferon-containing regimens are associated with low response rates owing to treatment-limiting toxic effects in immunosuppressed liver-transplant recipients. We ...
  19. An interferon-free antiviral regimen for HCV after liver transplantation.

    New England Journal of Medicine 371(25):2375 (2014) PMID 25386767

    Hepatitis C virus (HCV) infection is the leading indication for liver transplantation worldwide, and interferon-containing regimens are associated with low response rates owing to treatment-limiting toxic effects in immunosuppressed liver-transplant recipients. We evaluated the interferon-free r...
  20. An Interferon-free Antiviral Regimen for HCV after Liver Transplantation

    New England Journal of Medicine 371(25):2375 (2014)

    Background Hepatitis C virus (HCV) infection is the leading indication for liver transplantation worldwide, and interferon-containing regimens are associated with low response rates owing to treatment-limiting toxic effects in immunosuppressed liver-transplant recipients. We ...