1. Small molecule mediated inhibition of RORγ-dependent gene expression and autoimmune disease pathology in vivo.

    Immunology 147(4):399 (2016) PMID 26694902 PMCID PMC4799885

    Retinoic acid receptor-related orphan nuclear receptor γ (RORγ) orchestrates a pro-inflammatory gene expression programme in multiple lymphocyte lineages including T helper type 17 (Th17) cells, γδ T cells, innate lymphoid cells and lymphoid tissue inducer cells. There is compelling evidence tha...
  2. Quantitation of beta-amyloid in transgenic mice using whole slide digital imaging and image analysis software

    Alzheimer's & Dementia 7(4):S700 (2011)

  3. The role of brain macrophages on the clearance of amyloid plaques following the treatment of Tc2576 with BIIB037

    Alzheimer's & Dementia 7(4):S700 (2011)

  4. Molecular characterization and preclinical efficacy

    Alzheimer's & Dementia 7(4):S457 (2011)

  5. P27: GLP compliance with European Union Annex 11 in whole slide imaging

    Experimental and Toxicologic Pathology 61(4):413 (2009)

    Whole slide digital images can be produced from glass slides at resolutions of 20×, 40×, and 100×, and assembled without producing image artifacts or seams. This technology offers exciting opportunities in toxicology, for recording results, viewing images remotely, and for applying quantita...
  6. Establishment and characteristics of Gottingen minipig skin in organ culture and monolayer cell culture: relevance to drug safety testing.

    In Vitro Cellular & Developmental Biology - Animal 44(7):245 (2008) PMID 18568375

    Skin from Gottingen minipigs was used as a source of tissue for organ and cell culture and compared to human skin for growth conditions and sensitivity to irritants. Optimal organ culture conditions were determined, based on the preservation of the histological structure. These included serum-fr...
  7. Human skin in organ culture and human skin cells (keratinocytes and fibroblasts) in monolayer culture for assessment of chemically induced skin damage.

    Toxicologic Pathology 35(5):693 (2007) PMID 17763283

    Human skin cells (epidermal keratinocytes and dermal fibroblasts) in monolayer culture and human skin in organ culture were exposed to agents that are known to produce irritation (redness, dryness, edema and scaly crusts) when applied topically to skin. Among the agents used were three well acce...
  8. Morphologic, immunohistochemical, and molecular characterization of hepatosplenic T-cell lymphoma in a dog.

    Veterinary Clinical Pathology 33(2):105 (2004) PMID 15195270

    A 13-year-old neutered male Jack Russell Terrier (Parson Russell Terrier) was presented to the Texas Veterinary Medical Center with a history of lethargy, depression, vomiting, and fever. The dog had mildly regenerative anemia, severe thrombocytopenia and low antithrombin activity. Marked spleno...
  9. P2-005 Gamma secretase inhibitor-induced coat color changes in a novel animal model, the degu (Octodon degus)

    Neurobiology of Aging 25:S225 (2004)