1. Comment on: HMGB1-dependent and -independent autophagy.

    Autophagy 11(7):1187 (2015) PMID 26121576

    HMGB1 (high mobility group box 1), a ubiquitously expressed DNA-binding nucleoprotein, has not only been attributed with important functions in the regulation of gene expression but is thought to function as an important damage-associated molecular pattern in the extracellular space. Recently, c...
  2. Origin and function of myofibroblasts in the liver.

    Seminars in Liver Disease 35(2):e1 (2015) PMID 26008640

  3. Hepatic inflammation and fibrosis: Functional links and key pathways.

    Hepatology 61(3):1066 (2015) PMID 25066777 PMCID PMC4306641

    Inflammation is one of the most characteristic features of chronic liver disease of viral, alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease stages and associated with the development of fibrosis, cirrhosis, and hepatocellular carcinoma. In the past decade...
  4. Hepatic inflammation and fibrosis: Functional links and key pathways.

    Hepatology 61(3):1066 (2015) PMID 25066777

    Inflammation is one of the most characteristic features of chronic liver disease of viral, alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease stages and associated with the development of fibrosis, cirrhosis, and hepatocellular carcinoma. In the past decade...
  5. Hepatic inflammation and fibrosis: functional links and key pathways.

    Hepatology 61(3):1066 (2015) PMID 25066777 PMCID PMC4306641

    Inflammation is one of the most characteristic features of chronic liver disease of viral, alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease stages and associated with the development of fibrosis, cirrhosis, and hepatocellular carcinoma. In the past decade...
  6. Hepatic inflammation and fibrosis: Functional links and key pathways.

    Hepatology 61(3):1066 (2015) PMID 25066777 PMCID PMC4306641

    Inflammation is one of the most characteristic features of chronic liver disease of viral, alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease stages and associated with the development of fibrosis, cirrhosis, and hepatocellular carcinoma. In the past decade...
  7. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.

    Journal of Clinical Investigation 125(2):539 (2015) PMID 25562324

    In contrast to microbially triggered inflammation, mechanisms promoting sterile inflammation remain poorly understood. Damage-associated molecular patterns (DAMPs) are considered key inducers of sterile inflammation following cell death, but the relative contribution of specific DAMPs, including...
  8. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.

    Journal of Clinical Investigation 125(2):539 (2015) PMID 25562324

    In contrast to microbially triggered inflammation, mechanisms promoting sterile inflammation remain poorly understood. Damage-associated molecular patterns (DAMPs) are considered key inducers of sterile inflammation following cell death, but the relative contribution of specific DAMPs, including...
  9. High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers.

    Nature Protocols 10(2):305 (2015) PMID 25612230

    Hepatic stellate cells (HSCs) have been identified as the main fibrogenic cell type in the liver. Hence, efforts to understand hepatic fibrogenesis and to develop treatment strategies have focused on this cell type. HSC isolation, originally developed in rats, has subsequently been adapted to mi...
  10. High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers.

    Nature Protocols 10(2):305 (2015) PMID 25612230

    Hepatic stellate cells (HSCs) have been identified as the main fibrogenic cell type in the liver. Hence, efforts to understand hepatic fibrogenesis and to develop treatment strategies have focused on this cell type. HSC isolation, originally developed in rats, has subsequently been adapted to mi...
  11. High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers.

    Nature Protocols 10(2):305 (2015) PMID 25612230

    Hepatic stellate cells (HSCs) have been identified as the main fibrogenic cell type in the liver. Hence, efforts to understand hepatic fibrogenesis and to develop treatment strategies have focused on this cell type. HSC isolation, originally developed in rats, has subsequently been adapted to mi...
  12. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.

    Journal of Clinical Investigation 125(2):539 (2015) PMID 25562324

    In contrast to microbially triggered inflammation, mechanisms promoting sterile inflammation remain poorly understood. Damage-associated molecular patterns (DAMPs) are considered key inducers of sterile inflammation following cell death, but the relative contribution of specific DAMPs, including...
  13. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

    Cell 160(1-2):269 (2015) PMID 25594183 PMCID PMC4436082

    The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fa...
  14. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

    Cell 160(1-2):269 (2015) PMID 25594183

    The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fa...
  15. Mouse models of liver cancer.

    Methods in Molecular Biology 1267:165 (2015) PMID 25636469

    Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, and the third leading cause of cancer mortality. The great majority of patients are not eligible for curative therapies, and therapeutic approaches for advanced disease show only limited efficacy. Difficulties to treat HCC...
  16. Mouse models of liver cancer.

    Methods in Molecular Biology 1267:165 (2015) PMID 25636469

    Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, and the third leading cause of cancer mortality. The great majority of patients are not eligible for curative therapies, and therapeutic approaches for advanced disease show only limited efficacy. Difficulties to treat HCC...
  17. NAD+ Supplementation as a Novel Approach to cURIng HCC?

    Cancer Cell 26(6):777 (2014)

    In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD+) metabo...
  18. NAD(+) supplementation as a novel approach to cURIng HCC?

    Cancer Cell 26(6):777 (2014) PMID 25490440

    In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD(+)) metabolism. Th...
  19. NAD(+) Supplementation as a Novel Approach to cURIng HCC?

    Cancer Cell 26(6):777 (2014) PMID 25490440

    In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD(+)) metabolism. Th...
  20. NAD(+) supplementation as a novel approach to cURIng HCC?

    Cancer Cell 26(6):777 (2014) PMID 25490440

    In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD(+)) metabolism. Th...