1. Biofilm Formation As a Response to Ecological Competition.

    PLoS Biology 13(7):e1002191 (2015) PMID 26158271 PMCID PMC4497666

    Bacteria form dense surface-associated communities known as biofilms that are central to their persistence and how they affect us. Biofilm formation is commonly viewed as a cooperative enterprise, where strains and species work together for a common goal. Here we explore an alternative model: bi...
  2. Natural products in soil microbe interactions and evolution.

    Natural Product Reports 32(7):956 (2015) PMID 26000872

    Covering: up to 2015In recent years, bacterial interspecies interactions mediated by small molecule natural products have been found to give rise to a surprising array of phenotypes in soil-dwelling bacteria, especially among Streptomyces and Bacillus species. This review examines these interspe...
  3. Division of Labor in Biofilms: the Ecology of Cell Differentiation.

    Microbiology spectrum 3(2) (2015) PMID 26104716

    The dense aggregation of cells on a surface, as seen in biofilms, inevitably results in both environmental and cellular heterogeneity. For example, nutrient gradients can trigger cells to differentiate into various phenotypic states. Not only do cells adapt physiologically to the local environme...
  4. On the evolution of bacterial multicellularity.

    Current Opinion in Microbiology 24:21 (2015) PMID 25597443 PMCID PMC4380822

    Multicellularity is one of the most prevalent evolutionary innovations and nowhere is this more apparent than in the bacterial world, which contains many examples of multicellular organisms in a surprising array of forms. Due to their experimental accessibility and the large and diverse genomic ...
  5. From cell differentiation to cell collectives: Bacillus subtilis uses division of labor to migrate.

    PLoS Biology 13(4):e1002141 (2015) PMID 25894589 PMCID PMC4403855

    The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environmental challenges that they separately cannot. One particular challenge that is important for microorganisms is migration. In...
  6. New tools for comparing microscopy images: quantitative analysis of cell types in Bacillus subtilis.

    Journal of Bacteriology 197(4):699 (2015) PMID 25448819

    Fluorescence microscopy is a method commonly used to examine individual differences between bacterial cells, yet many studies still lack a quantitative analysis of fluorescence microscopy data. Here we introduce some simple tools that microbiologists can use to analyze and compare their microsco...
  7. New tools for comparing microscopy images: quantitative analysis of cell types in Bacillus subtilis.

    Journal of Bacteriology 197(4):699 (2015) PMID 25448819 PMCID PMC4334194

    Fluorescence microscopy is a method commonly used to examine individual differences between bacterial cells, yet many studies still lack a quantitative analysis of fluorescence microscopy data. Here we introduce some simple tools that microbiologists can use to analyze and compare their microsco...
  8. Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis.

    Scientific reports 5:9383 (2015) PMID 25807046

    Bacilli are ubiquitous low G+C environmental Gram-positive bacteria that produce a wide assortment of specialized small molecules. Although their natural product biosynthetic potential is high, robust molecular tools to support the heterologous expression of large biosynthetic gene clusters in B...
  9. Draft Genome Sequence of Erwinia tracheiphila, an Economically Important Bacterial Pathogen of Cucurbits.

    Genome Announcements 3(3) (2015) PMID 26044415 PMCID PMC4457052

    Erwinia tracheiphila is one of the most economically important pathogens of cucumbers, melons, squashes, pumpkins, and gourds in the northeastern and midwestern United States, yet its molecular pathology remains uninvestigated. Here, we report the first draft genome sequence of an E. tracheiphil...
  10. Sporulation during growth in a gut isolate of Bacillus subtilis.

    Journal of Bacteriology 196(23):4184 (2014) PMID 25225273 PMCID PMC4248874

    Sporulation by Bacillus subtilis is a cell density-dependent response to nutrient deprivation. Central to the decision of entering sporulation is a phosphorelay, through which sensor kinases promote phosphorylation of Spo0A. The phosphorelay integrates both positive and negative signals, ensurin...
  11. Sporulation during Growth in a Gut Isolate of Bacillus subtilis.

    Journal of Bacteriology 196(23):4184 (2014) PMID 25225273 PMCID PMC4248874

    Sporulation by Bacillus subtilis is a cell density-dependent response to nutrient deprivation. Central to the decision of entering sporulation is a phosphorelay, through which sensor kinases promote phosphorylation of Spo0A. The phosphorelay integrates both positive and negative signals, ensurin...
  12. Sporulation during growth in a gut isolate of Bacillus subtilis.

    Journal of Bacteriology 196(23):4184 (2014) PMID 25225273 PMCID PMC4248874

    Sporulation by Bacillus subtilis is a cell density-dependent response to nutrient deprivation. Central to the decision of entering sporulation is a phosphorelay, through which sensor kinases promote phosphorylation of Spo0A. The phosphorelay integrates both positive and negative signals, ensurin...
  13. Sporulation during growth in a gut isolate of Bacillus subtilis.

    Journal of Bacteriology 196(23):4184 (2014) PMID 25225273 PMCID PMC4248874

    Sporulation by Bacillus subtilis is a cell density-dependent response to nutrient deprivation. Central to the decision of entering sporulation is a phosphorelay, through which sensor kinases promote phosphorylation of Spo0A. The phosphorelay integrates both positive and negative signals, ensurin...
  14. Sporulation during Growth in a Gut Isolate of Bacillus subtilis.

    Journal of Bacteriology 196(23):4184 (2014) PMID 25225273

    Sporulation by Bacillus subtilis is a cell density-dependent response to nutrient deprivation. Central to the decision of entering sporulation is a phosphorelay, through which sensor kinases promote phosphorylation of Spo0A. The phosphorelay integrates both positive and negative signals, ensurin...
  15. Structural and Functional Analysis of Bacillus subtilis YisP Reveals a Role of Its Product in Biofilm Production.

    Chemistry & Biology 21(11):1557 (2014) PMID 25308276 PMCID PMC4252625

    YisP is involved in biofilm formation in Bacillus subtilis and has been predicted to produce C30 isoprenoids. We determined the structure of YisP and observed that it adopts the same fold as squalene and dehydrosqualene synthases. However, the first aspartate-rich motif found in essentially all ...
  16. Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production.

    Chemistry & Biology 21(11):1557 (2014) PMID 25308276 PMCID PMC4252625

    YisP is involved in biofilm formation in Bacillus subtilis and has been predicted to produce C30 isoprenoids. We determined the structure of YisP and observed that it adopts the same fold as squalene and dehydrosqualene synthases. However, the first aspartate-rich motif found in essentially all ...
  17. Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production.

    Chemistry & Biology 21(11):1557 (2014) PMID 25308276 PMCID PMC4252625

    YisP is involved in biofilm formation in Bacillus subtilis and has been predicted to produce C30 isoprenoids. We determined the structure of YisP and observed that it adopts the same fold as squalene and dehydrosqualene synthases. However, the first aspartate-rich motif found in essentially all ...
  18. Mutualistic interaction between Salmonella enterica and Aspergillus niger and its effects on Zea mays colonization.

    Microbial Biotechnology 7(6):589 (2014) PMID 25351041

    Salmonella Typhimurium inhabits a variety of environments and is able to infect a broad range of hosts. Throughout its life cycle, some hosts can act as intermediates in the path to the infection of others. Aspergillus niger is a ubiquitous fungus that can often be found in soil or associated to...
  19. Mutualistic interaction between Salmonella enterica and Aspergillus niger and its effects on Zea mays colonization.

    Microbial Biotechnology 7(6):589 (2014) PMID 25351041 PMCID PMC4265077

    Salmonella Typhimurium inhabits a variety of environments and is able to infect a broad range of hosts. Throughout its life cycle, some hosts can act as intermediates in the path to the infection of others. Aspergillus niger is a ubiquitous fungus that can often be found in soil or associated to...
  20. Mutualistic interaction between Salmonella enterica and Aspergillus niger and its effects on Zea mays colonization.

    Microbial Biotechnology 7(6):589 (2014) PMID 25351041 PMCID PMC4265077

    Salmonella Typhimurium inhabits a variety of environments and is able to infect a broad range of hosts. Throughout its life cycle, some hosts can act as intermediates in the path to the infection of others. Aspergillus niger is a ubiquitous fungus that can often be found in soil or associated to...